Sideroblastic anemia medical therapy
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Non pharmacologic and general measures
- Avoid alcohol
- Avoid zinc supplements
- Remove toxic agents
- Blood transfusion
- Blood transfusion can treat anemia but carries the risk of iron overload.
- Medications are used to control, anemia, morbidity and complications.
- The two groups are
- Folic acid
- Preferred regimen: Adults 0.4mg PO once daily
- Preferred regimen: Pediatric: 1 mg/day IV/PO/IM/SC initially, then 0.1-0.4 mg/day
- Preferred regimen: Adults: 50mg PO once daily
- Preferred regimen(1): Pediatric: 10-25 mg IV/IM qDay
- Preferred regimen(2): Pediatric: 10-50 mg PO qDay for 2 weeks, then 5-10 mg/day PO for 1 month
- Used in patietns having iron overload to remove toxic iron from tissues.
- Preferred regimen(1): Adults: Desferal 0.5-1g I/M daily
- Preferred regimen(2): Adults: Desferal 20-40mg/kg/day SC over 8-24 hours with portable pump providing continuous mini-infusion
- Preferred regimen(1): Pediatric: Desferal SC 1-2g (20-40mg/kg/day) SC over 8-24 hours by small portable pump
- Preferred regimen(2): Pediatric: Desferal IV, 40-50mg/kg/day over 8-12 hours for 5-7 days/ week,maximum, < 60mg/kg/day and an IV infusion rate of <15mg/kg/hr)
- Fujiwara T, Harigae H (December 2013). "Pathophysiology and genetic mutations in congenital sideroblastic anemia". Pediatr Int. 55 (6): 675–9. doi:10.1111/ped.12217. PMID 24003969.
- Mason DY, Emerson PM (February 1973). "Primary acquired sideroblastic anaemia: response to treatment with pyridoxal-5-phosphate". Br Med J. 1 (5850): 389–90. PMC 1588335. PMID 4691061.