Riedel's thyroiditis medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

Pharmacologic medical therapies for Riedel's thyroiditis include corticosteroids, tamoxifen, and mycophenolate mofetil.

Medical Therapy

Treatment regimens for Riedel's thyroiditis

The effectiveness of therapy and dosages for Riedel's thyroiditis have not yet been assessed completely. As a result, the exact dosage regimens and duration of therapy cannot be defined. The current recommendations are based on the clinical manifestations, associated conditions, and the response to treatment.

  • Preferred regimen (1): Prednisone 15-60mg PO q24h for 6 months to 2 years
  • Preferred regimen (2): Prednisone 500 mg PO q24h for 6 months to 2 years
  • Alternative regimen (1): Tamoxifen 10-20 mg PO q24h for 6 months to 2 years
  • Alternative regimen (1): Mycophenolate mofetil 1 g PO q12h for 6 months to 2 years

References

  1. Zimmermann-Belsing T, Feldt-Rasmussen U (1994). "Riedel's thyroiditis: an autoimmune or primary fibrotic disease?". J. Intern. Med. 235 (3): 271–4. PMID 8120524.
  2. Vaidya B, Harris PE, Barrett P, Kendall-Taylor P (1997). "Corticosteroid therapy in Riedel's thyroiditis". Postgrad Med J. 73 (866): 817–9. PMC 2431527. PMID 9497955.
  3. Chopra D, Wool MS, Crosson A, Sawin CT (1978). "Riedel's struma associated with subacute thyroiditis, hypothyroidism, and hypoparathyroidism". J. Clin. Endocrinol. Metab. 46 (6): 869–71. doi:10.1210/jcem-46-6-869. PMID 263470.
  4. Bagnasco M, Passalacqua G, Pronzato C, Albano M, Torre G, Scordamaglia A (1995). "Fibrous invasive (Riedel's) thyroiditis with critical response to steroid treatment". J. Endocrinol. Invest. 18 (4): 305–7. doi:10.1007/BF03347818. PMID 7560814.
  5. Thomson JA, Jackson IM, Duguid WP (1968). "The effect of steroid therapy on Riedel's thyroiditis". Scott Med J. 13 (1): 13–6. doi:10.1177/003693306801300103. PMID 5694137.
  6. Dabelic N, Jukic T, Labar Z, Novosel SA, Matesa N, Kusic Z (2003). "Riedel's thyroiditis treated with tamoxifen" (PDF). Croat. Med. J. 44 (2): 239–41. PMID 12698518.
  7. Levy JM, Hasney CP, Friedlander PL, Kandil E, Occhipinti EA, Kahn MJ (2010). "Combined mycophenolate mofetil and prednisone therapy in tamoxifen- and prednisone-resistant Reidel's thyroiditis". Thyroid. 20 (1): 105–7. doi:10.1089/thy.2009.0324. PMID 20067381.
  8. Fatourechi MM, Hay ID, McIver B, Sebo TJ, Fatourechi V (2011). "Invasive fibrous thyroiditis (Riedel thyroiditis): the Mayo Clinic experience, 1976-2008". Thyroid. 21 (7): 765–72. doi:10.1089/thy.2010.0453. PMID 21568724.


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