p27 (gene)
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
|
WikiDoc Resources for P27 (gene) | |
|
Articles | |
|---|---|
|
Most recent articles on P27 (gene) | |
|
Media | |
|
Evidence Based Medicine | |
|
Clinical Trials | |
|
Ongoing Trials on P27 (gene) at Clinical Trials.gov Clinical Trials on P27 (gene) at Google
| |
|
Guidelines / Policies / Govt | |
|
US National Guidelines Clearinghouse on P27 (gene)
| |
|
Books | |
|
News | |
|
Commentary | |
|
Definitions | |
|
Patient Resources / Community | |
|
Patient resources on P27 (gene) Discussion groups on P27 (gene) Patient Handouts on P27 (gene) Directions to Hospitals Treating P27 (gene) Risk calculators and risk factors for P27 (gene)
| |
|
Healthcare Provider Resources | |
|
Causes & Risk Factors for P27 (gene) | |
|
Continuing Medical Education (CME) | |
|
International | |
|
| |
|
Business | |
|
Experimental / Informatics | |
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Overview
p27 is a human gene on chromosome 6 and belongs to the cip/kip family. It encodes a cell cycle inhibitor protein that binds to cyclin D and CDK4 and causes arrest in G1 phase. p27 is activated by Transforming Growth Factor β (TGF β). [1] A mutation of this gene may lead to loss of control over the cell cycle leading to uncontrolled cellular proliferation. [2]
References
- ↑ p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21 Hideo Toyoshima, Tony Hunter; Cell, Vol 78, 67-74, 15 July 1994
- ↑ Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27Kip1 Cell Press. , Vol 85, 721-732, 31 May 1996
Cell cycle proteins | |
|---|---|
| Cyclin | A - B - D - E |
| Cyclin-dependent kinase | 2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - 10 - CDK-activating kinase |
| Cyclin-dependent kinase inhibitor protein | p14arf/p16INK4a - p21 - p27 - p57 |
| Other | Cdc2 - Cdc25 - Cdc42 - Cellular apoptosis susceptibility protein - E2F - Maturation promoting factor - Wee |
Tumor suppressor genes/proteins |
|---|
| APC - BRCA1 - BRCA2 - CHEK2 - Neurofibromin 1 - Maspin - Neurofibromin 2/Merlin - p14arf - p16 - p21 - p27 - p53 - p57 - p73 - pRb - PTEN - SDHB - SDHD - VHL |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
