List of bestselling drugs

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The following is a list of the top 200 pharmaceutical products ranked by sales.

Rank 2006 Brand Name(s) Generic Name Sales 2006 (USD millions) Change from 2005 Company(ies) Disease/Medical Use First Approval Date
1 Lipitor Atorvastatin 14,385 7% Pfizer, Astellas Pharma Cholesterol Dec-1996
2 Advair, Seretide Fluticasone + Salmeterol 6,129 12% GlaxoSmithKline Asthma Aug-2000
3 Plavix, Iscover Clopidogrel 6,057 -5% Bristol-Myers Squibb, Sanofi-Aventis Thrombotic events Nov-1997
4 Nexium Esomeprazole 5,182 12% AstraZeneca Gastrointestinal disorders Mar-2000
5 Norvasc Amlodipine 4,866 3% Pfizer Hypertension Jul-1992
6 Remicade Infliximab 4,428 23% Johnson & Johnson, Schering-Plough, Tanabe Rheumatoid arthritis Aug-1998
7 Enbrel Etanercept 4,379 20% Amgen, Wyeth Rheumatoid arthritis Nov-1998
8 Zyprexa Olanzapine 4,364 4% Eli Lilly Schizophrenia Sep-1996
9 Diovan Valsartan 4,223 15% Novartis Hypertension Dec-1996
10 Risperdal Risperidone 4,183 18% Johnson & Johnson Schizophrenia Dec-1993
11 Aranesp Darbepoetin alfa 4,121 26% Amgen Anemia Jun-2001
12 Rituxan, MabThera Rituximab 3,861 16% Roche, Genentech, Biogen Idec, Chugai Pharmaceutical Non-Hodgkin’s lymphoma Nov-1997
13 Effexor Venlafaxine 3,722 8% Wyeth Depression Dec-1993
14 Protonix, Pantozol, Pantoloc Pantoprazole 3,621 4% Wyeth, Altana, Solvay Gastrointestinal disorders Feb-2000
15 Singulair Montelukast 3,579 20% Merck & Co. Asthma Feb-1998
16 Seroquel Quetiapine 3,560 23% AstraZeneca, Astellas Pharma Schizophrenia Sep-1997
17 Prevacid, Takepron Lansoprazole 3,425 3% TAP Pharmaceuticals, Takeda Pharmaceutical Gastrointestinal disorders May-1995
18 Procrit, Eprex Erythropoietin 3,180 -4% Johnson & Johnson Anemia Dec-1990
19 Cozaar, Hyzaar Losartan 3,163 4% Merck & Co. Hypertension Apr-1995
20 Fosamax Alendronate 3,134 -2% Merck & Co. Osteoporosis Sep-1995
21 Herceptin Trastuzumab 3,134 83% Roche, Genentech, Chugai Pharmaceutical Breast cancer Sep-1998
22 Lovenox, Clexane Enoxaparin 3,059 14% Sanofi-Aventis Deep-vein thrombosis Mar-1993
23 Avandia, Avandamet, Avandaryl Rosiglitazone 3,043 26% GlaxoSmithKline Type 2 diabetes May-1999
24 Actos Pioglitazone 2,880 25% Takeda Pharmaceutical, Eli Lilly Type 2 diabetes Jul-1999
25 Zocor Simvastatin 2,803 -36% Merck & Co. Cholesterol Dec-1991
26 Copaxone Glatiramer 2,757 19% Teva Pharmaceutical Industries, Sanofi-Aventis Multiple sclerosis Dec-1996
27 AcipHex, Pariet Rabeprazole 2,729 -4% Eisai, Johnson & Johnson Gastrointestinal disorders Aug-1999
28 Neulasta Filgrastim 2,710 18% Amgen Neutropenia Jan-2002
29 Lexapro, Cipralex Escitalopram 2,696 16% Forest Laboratories, H. Lundbeck Major depressive disorder Aug-2002
30 Gleevec, Glivec Imatinib 2,554 18% Novartis Leukemia May-2001
31 Ambien, Stilnox Zolpidem 2,545 33% Sanofi-Aventis Insomnia Dec-1992
32 Aricept Donepezil 2,519 24% Eisai, Pfizer Alzheimer’s disease Nov-1996
33 Epogen Erythropoietin 2,511 2% Amgen Anemia Jun-1989
34 Zyrtec, Cirrus Cetirizine 2,377 9% Pfizer, UCB, Daiichi Sankyo Allergic rhinitis Dec-1995
35 Avapro, Aprovel, Avalide Irbesartan 2,372 13% Sanofi-Aventis, Bristol-Myers Squibb Hypertension Sep-1997
36 Avastin Bevacizumab 2,364 78% Roche, Genentech Colorectal cancer Feb-2004
37 Taxotere Docetaxel 2,201 9% Sanofi-Aventis Cancer Oct-1995
38 Eloxatin, Eloxatine Oxaliplatin 2,127 8% Sanofi-Aventis Colorectal cancer Aug-2002
39 Zoloft Sertraline 2,110 -35% Pfizer Depression Dec-1991
40 Tamiflu Oseltamivir 2,096 69% Roche, Chugai Pharmaceutical Influenza Oct-1999
41 Lantus Insulin analog 2,093 37% Sanofi-Aventis Type 2 diabetes and type 1 diabetes Apr-2000
42 Crestor Rosuvastatin 2,049 61% AstraZeneca, Shionogi Cholesterol Nov-2002
43 Humira Adalimumab 2,044 46% Abbott Laboratories Rheumatoid arthritis Dec-2002
44 Celebrex Celecoxib 2,039 18% Pfizer Osteoarthritis and rheumatoid arthritis Dec-1998
45 Topamax Topiramate 2,027 21% Johnson & Johnson Seizures Dec-1996
46 Prevnar vaccine 1,961 30% Wyeth Pneumococcal disease Feb-2000
47 Vytorin Ezetimibe + Simvastatin 1,955 90% Merck & Co., Schering-Plough Cholesterol Jul-2004
48 Zetia Ezetimibe 1,929 38% Merck & Co., Schering-Plough Cholesterol Oct-2002
49 Wellbutrin Bupropion 1,926 26% GlaxoSmithKline, Biovail Depression Aug-2003
50 Abilify Aripiprazole 1,900 1% Otsuka Pharmaceutical, Bristol-Myers Squibb Schizophrenia Nov-2002
51 Lamictal Lamotrigine 1,843 19% GlaxoSmithKline Seizures Dec-1994
52 Toprol, Seloken Metoprolol 1,795 3% AstraZeneca Hypertension Jan-1992
53 NeoRecormon, Epogin Erythropoietin 1,777 -1% Roche, Chugai Pharmaceutical Anemia Jul-1997
54 Atacand, Blopress Candesartan 1,768 8% Takeda Pharmaceutical, AstraZeneca Hypertension Oct-1997
55 Spiriva Tiotropium 1,735 45% Boehringer Ingelheim Chronic obstructive pulmonary disease Apr-2002
56 Avonex Interferon beta-1a 1,707 11% Biogen Idec Multiple sclerosis May-1996
57 Viagra Sildenafil 1,657 1% Pfizer Erectile dysfunction Mar-1998
58 Micardis Telmisartan 1,645 35% Boehringer Ingelheim, Astellas Pharma Hypertension Nov-1998
59 Actonel Risedronate 1,619 -4% Procter & Gamble, Sanofi-Aventis Osteoporosis Mar-1998
60 Lupron, Leuplin Leuprolide 1,579 1% Takeda Pharmaceutical, TAP Pharmaceuticals Prostate cancer Jan-1989
61 TriCor, Lipanthyl Fenofibrate 1,567 38% Abbott Laboratories, Solvay Cholesterol Feb-1998
62 Zofran Ondansetron 1,567 3% GlaxoSmithKline Nausea and vomiting Dec-1992
63 Valtrex Valaciclovir 1,563 24% GlaxoSmithKline Herpes Jun-1995
64 Levaquin, Floxin Levofloxacin 1,530 3% Johnson & Johnson Bacterial infections Dec-1996
65 Arimidex Anastrozole 1,508 28% AstraZeneca Breast cancer Dec-1995
66 Prograf Tacrolimus 1,499 20% Astellas Pharma Transplant rejection Apr-1993
67 CellCept Mycophenolate mofetil 1,470 8% Roche, Chugai Pharmaceutical Transplant rejection May-1995
68 Xalatan, Xalacom Latanoprost 1,453 6% Pfizer Intraocular pressure Jun-1996
69 Rebif Interferon beta-1a 1,452 14% Serono Multiple sclerosis Feb-1998
70 Coreg Carvedilol 1,441 38% GlaxoSmithKline Hypertension Sep-1995
71 Gemzar Gemcitabine 1,408 5% Eli Lilly Cancer May-1996
72 Prilosec, Losec Omeprazole 1,371 -17% AstraZeneca Gastrointestinal disorders Sep-1989
73 Benicar, Olmetec Olmesartan 1,370 73% Daiichi Sankyo, Forest Laboratories Hypertension Apr-2002
74 Lotrel Amlodipine + Benazepril 1,352 26% Novartis Hypertension Jun-1999
75 Cymbalta Duloxetine 1,316 94% Eli Lilly Depressive disorder Aug-2004
76 Imitrex, Imigran Sumatriptan 1,315 4% GlaxoSmithKline Migraine Dec-1992
77 Depakote Valproate 1,308 19% Abbott Laboratories Seizures Mar-1983
78 Humalog Insulin analog 1,300 8% Eli Lilly Diabetes Apr-1996
79 Duragesic Fentanyl 1,295 -18% Johnson & Johnson Pain Aug-1990
80 Pulmicort Budesonide 1,292 11% AstraZeneca Asthma Jun-1997
81 Zometa Zoledronate 1,283 5% Novartis Hypercalcemia Aug-2000
82 Betaseron, Betaferon Interferon beta-1b 1,245 14% Schering AG Multiple sclerosis Jul-1993
83 Delix, Tritace Ramipril 1,227 -3% Sanofi-Aventis Hypertension Jul-2000
84 Flovent, Flixotide Fluticasone 1,219 5% GlaxoSmithKline Asthma Mar-1996
85 Neupogen Filgrastim 1,213 0% Amgen Neutropenia Feb-1991
86 Casodex Bicalutamide 1,206 7% AstraZeneca Prostate cancer Oct-1995
87 Pravachol Pravastatin 1,197 -47% Bristol-Myers Squibb Cholesterol Oct-1991
88 Truvada Tenofovir + Emtricitabine 1,194 110% Gilead Sciences HIV infection Aug-2004
89 Symbicort Budesonide + Formoterol 1,184 18% AstraZeneca Asthma Aug-2000
90 Pegasys Pegylated interferon alfa-2a 1,171 5% Roche, Chugai Pharmaceutical Hepatitis C Jun-2002
91 Evista Raloxifene 1,159 4% Eli Lilly, Chugai Pharmaceutical Osteoporosis Dec-1997
92 Flomax Tamsulosin 1,158 28% Boehringer Ingelheim Benign prostatic hypertrophy Oct-1997
93 Lyrica Pregabalin 1,156 297% Pfizer Neuropathic pain Jul-2004
94 Paxil, Seroxat Paroxetine 1,147 3% GlaxoSmithKline Depression Dec-1992
95 Kaletra Lopinavir 1,135 13% Abbott Laboratories HIV infection Mar-2001
96 Detrol Tolterodine 1,100 11% Pfizer Overactive bladder Mar-1998
97 Harnal Tamsulosin 1,085 -8% Astellas Pharma Benign prostatic hypertrophy Jul-1992
98 Erbitux Cetuximab 1,075 56% Bristol-Myers Squibb, Merck KGaA Colorectal cancer Feb-2004
99 Synagis Palivizumab 1,065 -9% MedImmune Respiratory syncytial virus Jun-1998
100 Augmentin Co-amoxiclav 1,055 -13% GlaxoSmithKline Bacterial infections Aug-1984
101 Premarin, Prempro, Premphase Estrogen 1,051 16% Wyeth Menopausal symptoms Nov-1995
102 Ortho contraceptives Estrogen + Progesterone 1,016 -11% Johnson & Johnson Contraception Apr-1984
103 Zoladex Goserelin 1,008 0% AstraZeneca Prostate cancer Dec-1989
104 Cerezyme Imiglucerase 1,007 8% Genzyme Gaucher disease Apr-1991
105 Cravit Levofloxacin 1,002 2% Daiichi Sankyo, Santen Pharmaceutical Bacterial infections Jun-1909
106 Yasmin Drospirenone 998 36% Schering AG Prevention of pregnancy Aug-2000
107 Kogenate Recombinant factor VIII 989 19% Bayer Hemophilia Feb-1993
108 Botox Botulin toxin 982 18% Allergan Cervical dystonia Dec-1989
109 Lamisil Terbinafine 978 -14% Novartis Fungal infections Dec-1992
110 Combivir Lamivudine + Zidovudine 977 -8% GlaxoSmithKline HIV infection Sep-1997
111 Zosyn, Tazocin Piperacillin 972 9% Wyeth Bacterial infections Oct-1993
112 Cialis Tadalafil 971 30% Lilly, Lilly Icos Erectile dysfunction Nov-2002
113 Keppra Levetiracetam 956 36% UCB Seizures Nov-1999
114 NovoSeven Factor VII 948 11% Novo Nordisk Bleeding due to hemophilia Feb-1996
115 Infanrix, Pediarix vaccine 945 21% GlaxoSmithKline Diphtheria, tetanus, and pertussis Jan-1996
116 Nasonex Mometasone 944 28% Schering-Plough Allergic rhinitis Oct-1997
117 Reyataz Atazanavir 931 34% Bristol-Myers Squibb HIV infection Jan-2003
118 Concerta Methylphenidate 930 20% Johnson & Johnson Attention-deficit hyperactivity disorder Aug-2000
119 Humulin Recombinant human insulin 925 -8% Eli Lilly Diabetes Oct-1982
120 Neoral, Sandimmun Ciclosporin 918 -4% Novartis Transplant rejection Jul-1995
121 Sandostatin Somatostatin 915 2% Novartis Acromegaly Oct-1988
122 Camptosar Irinotecan 903 -1% Pfizer Colorectal cancer Jun-1996
123 Engerix-B, Havrix, Twinrix vaccine 886 10% GlaxoSmithKline Hepatitis Aug-1989
124 Allegra, Telfast Fexofenadine 864 -49% Sanofi-Aventis Allergic rhinitis Jul-1996
125 Adderall Amphetamine 864 18% Shire Pharmaceuticals Attention-deficit hyperactivity disorder Oct-2001
126 Combivent Ipratropium + Salbutamol 843 20% Boehringer Ingelheim Chronic obstructive pulmonary disease Oct-1996
127 Peg-Intron Pegylated interferon alfa-2b 837 11% Schering-Plough Hepatitis C May-2000
128 Adalat Nifedipine 825 0% Bayer Hypertension Nov-1985
129 Avelox, Avalox Moxifloxacin 822 17% Bayer, Schering-Plough, Shionogi Bacterial infections Dec-1999
130 Mobic Meloxicam 818 -66% Boehringer Ingelheim, Daiichi Sankyo Osteoarthritis and rheumatoid arthritis Feb-1996
131 Biaxin Clarithromycin 816 -23% Abbott Laboratories Bacterial infections Oct-1991
132 Mevalotin Pravastatin 799 -35% Daiichi Sankyo Cholesterol Jun-1909
133 Ultane, Sevorane Sevoflurane 799 -9% Abbott Laboratories Anesthesia Jun-1995
134 Genotropin Somatropin 795 -2% Pfizer Growth failure Aug-1995
135 Sustiva Efavirenz 791 16% Bristol-Myers Squibb HIV infection Sep-1998
136 Zyvox Linezolid 782 27% Pfizer Bacterial infections Apr-2000
137 Xeloda Capecitabine 775 22% Roche, Chugai Pharmaceutical Cancer Jun-1909
138 Geodon, Zeldox Ziprasidone 758 29% Pfizer Schizophrenia Feb-2001
139 Cipro, Ciprobay Ciprofloxacin 755 -6% Bayer, Schering-Plough Bacterial infections Oct-1987
140 Provigil Modafinil 735 43% Cephalon Sleepiness Dec-1998
141 Lescol Fluvastatin 725 -5% Novartis Cholesterol Dec-1993
142 Clarinex, Aerius Desloratadine 722 12% Schering-Plough Allergic rhinitis Dec-2001
143 Femara Letrozole 722 35% Novartis, Chugai Pharmaceutical Breast cancer Jul-1997
144 Trileptal Oxcarbazepine 721 17% Novartis Seizures Nov-1999
145 Tracleer Bosentan 717 42% Actelion Pulmonary arterial hypertension Nov-2001
146 Primaxin Imipenem + Cilastatin 705 -5% Merck & Co. Bacterial infections Nov-1985
147 Temodar Temozolomide 703 20% Schering-Plough Anaplastic astrocytoma Aug-1999
148 Trusopt, Cosopt Dorzolamide 697 13% Merck & Co. Intraocular pressure Dec-1994
149 Voltaren Diclofenac 690 0% Novartis Osteoarthritis and rheumatoid arthritis Jul-1998
150 Viread Tenofovir 689 -12% Gilead Sciences HIV infection Oct-2001
151 Sifrol Pramipexole 673 23% Boehringer Ingelheim Parkinson’s disease Oct-1997
152 Namenda Memantine 660 30% Forest Laboratories Alzheimer disease Oct-2003
153 Altace Ramipril 653 18% King Pharmaceuticals Cardiovascular events Jan-1991
154 Byetta Exenatide 649 464% Amylin Pharmaceuticals, Eli Lilly Type 2 diabetes Apr-2005
155 Tarceva Erlotinib 649 110% Roche, Genentech Non-small cell lung cancer Nov-2004
156 Zithromax, Zmax Azithromycin 638 -68% Pfizer Bacterial infections Nov-1991
157 Omnicef Cefdinir 637 29% Abbott Laboratories Bacterial infections Dec-1997
158 Proscar Finasteride 619 -16% Merck & Co. Benign prostatic hypertrophy Jun-1992
159 Alimta Pemetrexed 612 32% Eli Lilly Non-small cell lung cancer Feb-2004
160 Merrem Meropenem 604 20% AstraZeneca Bacterial infections Jun-1996
161 Forteo Teriparatide 594 53% Eli Lilly Osteoporosis Nov-2002
162 Strattera Atomoxetine 579 5% Eli Lilly Attention-deficit hyperactivity disorder Nov-2002
163 Actiq Fentanyl 578 40% Cephalon Cancer pain Nov-1998
164 Flonase, Flixonase Fluticasone 575 -52% GlaxoSmithKline Allergic rhinitis Oct-1994
165 Amaryl Glimepiride 567 -33% Sanofi-Aventis Type 2 diabetes Nov-1995
166 Lidoderm Lidocaine 567 35% Endo Pharmaceuticals Pain Mar-1999
167 Lunesta Eszopiclone 567 72% Sepracor Insomnia Dec-2004
168 Boniva, Bonviva Ibandronate 565 454% Roche, GlaxoSmithKline Osteoporosis Mar-2005
169 Taxol Paclitaxel 563 -25% Bristol-Myers Squibb Cancer Dec-1992
170 Zelnorm, Zelmac Tegaserod 561 34% Novartis Irritable bowel syndrome Mar-2002
171 Renagel Sevelamer 559 23% Genzyme, Roche, Chugai Pharmaceutical Hyperphosphatemia Oct-1998
172 Norditropin Human growth hormone 557 19% Novo Nordisk Growth hormone deficiency Jun-1909
173 Xopenex Levalbuterol 555 29% Sepracor Bronchospasm Mar-1999
174 Xenical Orlistat 553 9% Roche Obesity Jul-1998
175 Vasotec, Vaseretic Enalapril 547 -12% Merck & Co. Hypertension Dec-1985
176 Serevent Salmeterol 538 -10% GlaxoSmithKline Asthma Feb-1994
177 Cardura Doxazosin 538 -8% Pfizer Hypertension Nov-1990
178 Synthroid Levothyroxine 534 -4% Abbott Laboratories Hypothyroidism May-1909
179 Gonal-f Follitropin alfa 533 -3% Serono Infertility Oct-1995
180 Gaster Famotidine 532 -10% Astellas Pharma Gastrointestinal disorders Jun-1909
181 Cancidas Caspofungin 530 -7% Merck & Co. Fungal infections Jan-2001
182 Exelon Rivastigmine 525 12% Novartis Alzheimer’s disease May-1998
183 Vfend Voriconazole 515 30% Pfizer Fungal infections Mar-2002
184 Amlodin Amlodipine 506 4% Dainippon Sumitomo Hypertension, angina pectoris n/a
185 Niaspan Niacin 498 13% Kos Pharmaceuticals Cholesterol Jul-1997
186 Neurontin Gabapentin 496 -22% Pfizer Seizures Dec-1993
187 Trizivir Abacavir + Lamivudine + Zidovudine 496 -10% GlaxoSmithKline HIV infection Nov-2000
188 Requip Ropinirole 496 74% GlaxoSmithKline Parkinson disease Sep-1997
189 Follistim, Puregon Follitropin beta 482 8% Akzo Nobel Infertility Sep-1997
190 Basen Voglibose 476 -13% Takeda Pharmaceutical Hyperglycemia Jun-1909
191 Levitra Vardenafil 474 19% Bayer, GlaxoSmithKline Erectile dysfunction Mar-2003
192 Glucophage Metformin 459 -16% Merck KGaA, Bristol-Myers Squibb Type 2 diabetes Dec-1994
193 Concor Bisoprolol 455 4% Merck KGaA Hypertension Jul-1992
194 Epzicom, Kixeva Abacavir + Lamivudine 446 107% GlaxoSmithKline HIV infection Aug-2004
195 Xatral Alfuzosin 443 8% Sanofi-Aventis Benign prostatic hypertrophy Jan-2000
196 Diflucan Fluconazole 435 -13% Pfizer Fungal infections Jan-1990
197 Thalomid Thalidomide 433 12% Celgene Erythema nodosum leprosum Jul-1998
198 Zantac Ranitidine 429 -18% GlaxoSmithKline Gastrointestinal disorders Jun-1983
199 Xolair Omalizumab 429 32% Roche, Genentech Asthma Jun-2003
200 Claritin Loratadine 418 -5% Schering-Plough, Shionogi Allergic rhinitis Apr-1993

Source: MedAdNews 200 - World's Best-Selling Medicines, MedAdNews, July 2007


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