Pituitary adenoma classification

Jump to: navigation, search

Pituitary adenoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Pituitary adenoma from other Diseases

Epidemiology and Demographics

Risk Factors

Natural history, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Pituitary adenoma classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Pituitary adenoma classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Pituitary adenoma classification

CDC on Pituitary adenoma classification

Pituitary adenoma classification in the news

Blogs on Pituitary adenoma classification

Directions to Hospitals Treating Pituitary adenoma

Risk calculators and risk factors for Pituitary adenoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]

Overview

Pituitary adenoma may be classified according to the size of the adenoma and type of hormone secretion, subtypes include corticotrophic, somatotrophic, thyrotrophic, gonadotrophic, and lactrotrophic adenomas.

Classification

  • Historically, pituitary tumors were classified as basophilic, acidophilic, or chromophobic based on the positivity of hematoxylin and eosin stain.
  • Newer classification is based on either the size or the functional status of the adenoma (secretory vs. non-secretory).

Classification based on hormone secretion and immunohistochemical staining

Type of adenoma Secretion Staining Pathology
Corticotrophic adenomas Adrenocorticotropic hormone (ACTH) and pro-opiomelanocortin (POMC) Basophilic Cushing's disease
Somatotrophic adenomas Growth hormone (GH) Acidophilic Acromegaly (gigantism)
Thyrotrophic adenomas (rare) Thyroid-stimulating hormone (TSH) Basophilic Occasionally hyperthyroidism/Asymptomatic
Gonadotrophic adenomas Luteinizing hormone (LH), follicle-stimulating hormone (FSH) and their subunits Basophilic Asymptomatic
Lactrotrophic adenomas or prolactinomas (most common) Prolactin Acidophilic Galactorrhea, hypogonadism, amenorrhea, infertility, and impotence
Null cell adenomas Do not secrete hormones May stain positive for synaptophysin

Classification based on the size of the adenoma

Pituitary adenoma may be classified into 4 grades based on radioanatomical:[1]

  • Stage I involves microadenomas (<1 cm) without sella expansion
  • Stage II involves macroadenomas (≥1 cm) and may extend above the sella
  • Stage III involves macroadenomas with enlargement and invasion of the floor or suprasellar extension
  • Stage IV involves macroadenomas that cause destruction of the sella

References

  1. Pituitary adenoma (2015). http://www.cancer.gov/types/pituitary/hp/pituitary-treatment-pdq#section/_96. Accessed on 9/28/2015.

Linked-in.jpg