Synaptophysin
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| synaptophysin
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| Identifiers | |
| Symbol | SYP |
| Entrez | 6855 |
| HUGO | 11506 |
| OMIM | 313475 |
| RefSeq | NM_003179 |
| UniProt | P08247 |
| Other data | |
| Locus | Chr. X p11.23-p11.22 |
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US National Guidelines Clearinghouse on Synaptophysin NICE Guidance on Synaptophysin
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Overview
Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for neuroendocrine tumors.
The gene for this protein is located on the X chromosome (Xp11.23-p11.22). The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally.
External link
Tumor markers |
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| Alpha-fetoprotein/AFP-L3 - CA-125 - CA 19-9 - CD30 - Autocrine motility factor - Carcinoembryonic antigen - βHCG - erbB-2 receptor - erbB-3 receptor - NANOG - Neprilysin - Normetanephrine - PCNA - Prostate specific antigen - Synaptophysin |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
