Glioma medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2], Sujit Routray, M.D. [3]
Overview
Treatment for glioma depends on the location and grade. The predominant therapy for glioma is surgical resection. Adjunctive chemotherapy and radiation may be required.[1]
Medical Therapy
Treatment for glioma depends on the location and grade. The predominant therapy for glioma is surgical resection. Adjunctive chemotherapy and radiation may be required.[1]
Radiotherapy
- Post-operative radiation therapy is often used as an adjunct to surgery in the treatment of high-grade gliomas as it has shown to double the median survival for high-grade gliomas to 37 weeks (versus 17 weeks with surgery alone).
- Radiotherapy may not cure the cancer, but can control the tumor and delay recurrence.
- Targeted three-dimensional conformal radiotherapy is preferred to whole brain radiotherapy.
Chemotherapy
- Chemotherapy is indicated as adjuvant therapy for glioma.
- Temozolomide (Temodar) is the preferred drug for the treatment of high-grade and recurring low-grade glioma, as it easily penetrates the blood brain barrier.
- Other chemotherapeutic drugs that may be used for the treatment of glioma include:
References
- ↑ 1.0 1.1 Treatment of glioma. SurgWiki.com. http://www.surgwiki.com/wiki/Intracranial_tumours,_infection_and_aneurysms#Astrocytoma