Eukaryotic translation initiation factor 4 gamma 1

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External IDs	GeneCards: [1]
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Species	Human	Mouse
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Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene.

Function

The protein encoded by this gene is a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms. eIF4G serves as a scaffold, interacting with mRNA and the other components of the eIF4F complex, as well as the PABP and eIF3.

Interactions

Eukaryotic translation initiation factor 4 gamma has been shown to interact with MKNK1, EIF4A1, EIF4E, MKNK2 and PABPC1.

See also

• Eukaryotic initiation factor

Further reading

• Gingras AC, Raught B, Sonenberg N (2000). "eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation". Annual Review of Biochemistry. 68: 913–63. doi:10.1146/annurev.biochem.68.1.913. PMID 10872469.
• Yan R, Rhoads RE (Mar 1995). "Human protein synthesis initiation factor eIF-4 gamma is encoded by a single gene (EIF4G) that maps to chromosome 3q27-qter". Genomics. 26 (2): 394–8. doi:10.1016/0888-7543(95)80227-D. PMID 7601469.
• Mader S, Lee H, Pause A, Sonenberg N (Sep 1995). "The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins". Molecular and Cellular Biology. 15 (9): 4990–7. PMC 230746. PMID 7651417.
• Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC, Sonenberg N (Oct 1994). "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function". Nature. 371 (6500): 762–7. doi:10.1038/371762a0. PMID 7935836.
• Lamphear BJ, Yan R, Yang F, Waters D, Liebig HD, Klump H, Kuechler E, Skern T, Rhoads RE (Sep 1993). "Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus". The Journal of Biological Chemistry. 268 (26): 19200–3. PMID 8396129.
• Haghighat A, Mader S, Pause A, Sonenberg N (Nov 1995). "Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E". The EMBO Journal. 14 (22): 5701–9. PMC 394685. PMID 8521827.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Lamphear BJ, Rhoads RE (Dec 1996). "A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases". Biochemistry. 35 (49): 15726–33. doi:10.1021/bi961864t. PMID 8961935.
• Brass N, Heckel D, Sahin U, Pfreundschuh M, Sybrecht GW, Meese E (Jan 1997). "Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma". Human Molecular Genetics. 6 (1): 33–9. doi:10.1093/hmg/6.1.33. PMID 9002667.
• Eberle J, Krasagakis K, Orfanos CE (May 1997). "Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro". International Journal of Cancer. 71 (3): 396–401. doi:10.1002/(SICI)1097-0215(19970502)71:3<396::AID-IJC16>3.0.CO;2-E. PMID 9139875.
• Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (Jan 1998). "A novel functional human eukaryotic translation initiation factor 4G". Molecular and Cellular Biology. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501. PMID 9418880.
• Piron M, Vende P, Cohen J, Poncet D (Oct 1998). "Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F". The EMBO Journal. 17 (19): 5811–21. doi:10.1093/emboj/17.19.5811. PMC 1170909. PMID 9755181.
• Imataka H, Gradi A, Sonenberg N (Dec 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". The EMBO Journal. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMC 1171091. PMID 9857202.
• Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N (Jan 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". The EMBO Journal. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. PMC 1171121. PMID 9878069.
• Laroia G, Cuesta R, Brewer G, Schneider RJ (Apr 1999). "Control of mRNA decay by heat shock-ubiquitin-proteasome pathway". Science. 284 (5413): 499–502. doi:10.1126/science.284.5413.499. PMID 10205060.
• Vary TC, Jefferson LS, Kimball SR (Dec 1999). "Amino acid-induced stimulation of translation initiation in rat skeletal muscle". The American Journal of Physiology. 277 (6 Pt 1): E1077–86. PMID 10600798.
• Cuesta R, Laroia G, Schneider RJ (Jun 2000). "Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes". Genes & Development. 14 (12): 1460–70. PMC 316692. PMID 10859165.
• Chartier-Harlin MC, Dachsel JC, Vilariño-Güell C, Lincoln SJ, Leprêtre F, Hulihan MM, Kachergus J, Milnerwood AJ, Tapia L, Song MS, Le Rhun E, Mutez E, Larvor L, Duflot A, Vanbesien-Mailliot C, Kreisler A, Ross OA, Nishioka K, Soto-Ortolaza AI, Cobb SA, Melrose HL, Behrouz B, Keeling BH, Bacon JA, Hentati E, Williams L, Yanagiya A, Sonenberg N, Lockhart PJ, Zubair AC, Uitti RJ, Aasly JO, Krygowska-Wajs A, Opala G, Wszolek ZK, Frigerio R, Maraganore DM, Gosal D, Lynch T, Hutchinson M, Bentivoglio AR, Valente EM, Nichols WC, Pankratz N, Foroud T, Gibson RA, Hentati F, Dickson DW, Destée A, Farrer MJ (Sep 2011). "Translation initiator EIF4G1 mutations in familial Parkinson disease". American Journal of Human Genetics. 89 (3): 398–406. doi:10.1016/j.ajhg.2011.08.009. PMC 3169825. PMID 21907011.