Beriberi history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdelrahman Ibrahim Abushouk, MD[2]

Overview

The symptoms of beriberi are usually vague and therefore, the diagnosis must be considered in the clinical and geographical contexts. Common symptoms for wet beriberi include tachycardia, respiratory distress, and edema, while common symptoms for dry beriberi include parasthesia, muscle pain, weakness.

History and Symptoms

History of Beriberi

  • The majority of beriberi patients usually have no specific symptoms of beriberi.
  • Therefore, detailed history in the clinical and geographical context is valuable in these patients.
  • The patient should be asked about his diet regimen, alcohol consumption rate, and any surgeries in the past period.
  • Family history may be present in rare cases with genetic beriberi in which a genetic mutation interferes with thiamine absorption.

Symptoms of Beriberi

  • Neurological or dry beriberi is manifested by polyneuritis (sometimes paralysis) that typically starts in the lower limbs and progresses to the upper limbs,
  • Gastrointestinal symptoms are due to delayed gastric emptying and colon dilation.

References

  1. Chisolm-Straker M, Cherkas D (2013). "Altered and unstable: wet beriberi, a clinical review". J Emerg Med. 45 (3): 341–4. doi:10.1016/j.jemermed.2013.04.022. PMID 23849362.
  2. Shible AA, Ramadurai D, Gergen D, Reynolds PM (2019). "Dry Beriberi Due to Thiamine Deficiency Associated with Peripheral Neuropathy and Wernicke's Encephalopathy Mimicking Guillain-Barré syndrome: A Case Report and Review of the Literature". Am J Case Rep. 20: 330–334. doi:10.12659/AJCR.914051. PMC 6429982. PMID 30862772.
  3. Shible AA, Ramadurai D, Gergen D, Reynolds PM (2019). "Dry Beriberi Due to Thiamine Deficiency Associated with Peripheral Neuropathy and Wernicke's Encephalopathy Mimicking Guillain-Barré syndrome: A Case Report and Review of the Literature". Am J Case Rep. 20: 330–334. doi:10.12659/AJCR.914051. PMC 6429982. PMID 30862772.
  4. Chandrakumar A, Bhardwaj A, 't Jong GW (2018). "Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis". J Basic Clin Physiol Pharmacol. 30 (2): 153–162. doi:10.1515/jbcpp-2018-0075. PMID 30281514.


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