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Arachidonate 12-lipoxygenase, 12R type
Symbol(s) ALOX12B; 12R-LOX
External IDs OMIM: 603741 MGI1274782 Homologene884
RNA expression pattern

PBB GE ALOX12B 207381 at tn.png

More reference expression data

Human Mouse
Entrez 242 11686
Ensembl ENSG00000179477 ENSMUSG00000032807
Uniprot O75342 Q5NCF8
Refseq NM_001139 (mRNA)
NP_001130 (protein)
XM_977240 (mRNA)
XP_982334 (protein)
Location Chr 17: 7.92 - 7.93 Mb Chr 11: 68.97 - 68.99 Mb
Pubmed search [1] [2]

Arachidonate 12-lipoxygenase, 12R type, also known as ALOX12B, is a human gene.[1]

This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.[1]


Further reading

  • Yu Z, Schneider C, Boeglin WE, Brash AR (2007). "Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha.". Lipids. 42 (6): 491–7. PMID 17436029. doi:10.1007/s11745-007-3054-4. 
  • Lesueur F, Bouadjar B, Lefèvre C; et al. (2007). "Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.". J. Invest. Dermatol. 127 (4): 829–34. PMID 17139268. doi:10.1038/sj.jid.5700640. 
  • Yu Z, Schneider C, Boeglin WE, Brash AR (2005). "Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.". Biochim. Biophys. Acta. 1686 3: 238–47. PMID 15629692. doi:10.1016/j.bbalip.2004.10.007. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • McDonnell M, Li H, Funk CD (2003). "Characterization of epidermal 12(S) and 12(R) lipoxygenases.". Adv. Exp. Med. Biol. 507: 147–53. PMID 12664578. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Jobard F, Lefèvre C, Karaduman A; et al. (2002). "Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.". Hum. Mol. Genet. 11 (1): 107–13. PMID 11773004. 
  • Schneider C, Keeney DS, Boeglin WE, Brash AR (2001). "Detection and cellular localization of 12R-lipoxygenase in human tonsils.". Arch. Biochem. Biophys. 386 (2): 268–74. PMID 11368351. doi:10.1006/abbi.2000.2217. 
  • Krieg P, Marks F, Fürstenberger G (2001). "A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.". Genomics. 73 (3): 323–30. PMID 11350124. doi:10.1006/geno.2001.6519. 
  • Tang K, Finley RL, Nie D, Honn KV (2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.". Biochemistry. 39 (12): 3185–91. PMID 10727209. 
  • Sun D, McDonnell M, Chen XS; et al. (1999). "Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment.". J. Biol. Chem. 273 (50): 33540–7. PMID 9837935. 
  • Boeglin WE, Kim RB, Brash AR (1998). "A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression.". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6744–9. PMID 9618483.