Whipple's disease other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Bhagyashree Deshmankar M.B.B.S.[2]
Overview
Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Findings diagnostic of Whipple's disease include PAS positive inclusions in macrophages of lamina propria.
Other diagnostic studies for Whipple's disease include electron microscopy which demonstrate bacteria , immunofluoroscent assay to detect antibodies against T whippleii and PCR, which demonstrates 16S rRNA gene of T. Whipplei.
Other Diagnostic Studies
- Small bowel biopsy may be helpful in the diagnosis of Whipple's disease. Findings diagnostic of Whipple's disease include:[1]
- PAS positive inclusions in macrophages of lamina propria.
- All the organs affected by disease may demostrate PAS-positive macrophages like heart, lungs, CNS , eyes, liver, spleen, joints, and bone marrow.
- Other diagnostic studies for Whipple's disease which confirm the diagnosis include:
- Electron Microscopy, which demonstrates:[1]
- typical trilamellar membrane of T. Whippleii.
- gram positive cell wall structure
- 16S rRNA gene of T. Whipplei
- Immunofluoroscent assay of serum of patients with Whipple's disease which demonstrates:[1]
- Antibodies against T. Whippleii in patients' serum.