Von Willebrand disease causes: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
 
(5 intermediate revisions by 2 users not shown)
Line 9: Line 9:
==Causes==
==Causes==
===Life-threatening Causes===
===Life-threatening Causes===
*There are no life-threatening causes of [[disease name]], however complications resulting from untreated [[disease name]] is common.
*There are no life-threatening causes of von willebrand disease.


===Common Causes===
===Common Causes===
Common causes of [disease name] may include:
Common causes of von willebrand disease may include:<ref name="pmid4172730">{{cite journal| author=Simone JV, Cornet JA, Abildgaard CF| title=Acquired von Willebrand's syndrome in systemic lupus erythematosus. | journal=Blood | year= 1968 | volume= 31 | issue= 6 | pages= 806-12 | pmid=4172730 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4172730  }} </ref><ref name="pmid1083062">{{cite journal| author=Wautier JL, Levy-Toledano S, Caen JP| title=Acquired von Willebrand's syndrome and thrombopathy in a patient with chronic lymphocytic leukaemia. | journal=Scand J Haematol | year= 1976 | volume= 16 | issue= 2 | pages= 128-34 | pmid=1083062 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1083062  }} </ref>
*[Cause1]
*[[Chronic myeloid leukemia]]
*[Cause2]
*[[Chronic lymphocytic leukemia]]
*[Cause3]
*[[Wilms tumor]]
 
*[[Essential thrombocythemia]]
 
*[[Non-Hodgkin lymphoma]]
OR
*[[Mitral valve prolapse]]
 
*Ventricular assist device
 
*[[Ventricular septal defect]]
*[Disease name] is caused by an infection with [pathogen name].
*[[Aortic stenosis]]
*[Pathogen name] is caused by [pathogen name].
*[[Valproic acid]]
* [[Ciprofloxacin]]


===Less Common Causes===
===Less Common Causes===
Less common causes of [disease name] include:
Less common causes of von Willebrand disease include:<ref name="pmid17133419">{{cite journal| author=Franchini M, Lippi G| title=Acquired von Willebrand syndrome: an update. | journal=Am J Hematol | year= 2007 | volume= 82 | issue= 5 | pages= 368-75 | pmid=17133419 | doi=10.1002/ajh.20830 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17133419  }} </ref>
*[Cause1]
*[[Waldenström macroglobulinemia]]
*[Cause2]
*[[Multiple myeloma]]
*[Cause3]
*[[Polycythemia vera]]
*[[Wilms tumor]]
*[[Systemic lupus erythematosus]]
*[[Hypothyroidism]]
*[[Uremia]]
*[[Hemoglobinopathies]]
*[[Angiodysplasia]]


===Genetic Causes===
===Genetic Causes===
*[Disease name] is caused by a mutation in the [gene name] gene.
*The vWF gene is located on the short arm ''p'' of chromosome 12 (12p13.2) von Willebrand disease is caused by a mutation in this gene.


===Causes by Organ System===
===Causes by Organ System===
Line 37: Line 44:
{| style="width:80%; height:100px" border="1"
{| style="width:80%; height:100px" border="1"
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
| style="width:75%" bgcolor="Beige" ; border="1" | No underlying causes
| style="width:75%" bgcolor="Beige" ; border="1" |
*[[Mitral valve prolapse]]
*Ventricular assist device
*[[Ventricular septal defect]]
*[[Aortic stenosis]]
|-
|-
| bgcolor="LightSteelBlue" | '''Chemical/Poisoning'''
| bgcolor="LightSteelBlue" | '''Chemical/Poisoning'''
Line 52: Line 63:
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" |
*[[Valproic acid]]
* [[Ciprofloxacin]]
*[[Griseofulvin]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
Line 60: Line 74:
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| '''Endocrine'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" | [[Hypothyroidism]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
Line 72: Line 86:
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" |Mutations in vWF gene
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Hematologic'''
| '''Hematologic'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" |
*[[Chronic myeloid leukemia]]
*[[Chronic lymphocytic leukemia]]
*[[Polycythemia vera]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
Line 104: Line 121:
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Oncologic'''
| '''Oncologic'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" |
*[[Chronic myeloid leukemia]]
*[[Chronic lymphocytic leukemia]]
*[[Monoclonal gammopathy of undetermined significance]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
Line 124: Line 144:
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| '''Renal/Electrolyte'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" | [[Wilms tumor]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| '''Rheumatology/Immunology/Allergy'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" |
* [[Systemic lupus erythematosus]]
* [[Waldenström macroglobulinemia]]
* [[Monoclonal gammopathy of undetermined significance]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
Line 140: Line 163:
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Urologic'''
| '''Urologic'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" |[[Uremia]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
Line 151: Line 174:
List the causes of the disease in alphabetical order:
List the causes of the disease in alphabetical order:
<div style="-moz-column-count:3; column-count:3;">
<div style="-moz-column-count:3; column-count:3;">
* Cause 1
* [[Aortic stenosis]]
* Cause 2
* [[Angiodysplasia]]
* Cause 3
* [[Ciprofloxacin]]
* Cause 4
* [[Chronic myeloid leukemia]]
 
*[[Chronic lymphocytic leukemia]]
 
* [[Hypothyroidism]]
 
*[[Hemoglobinopathies]]
==Causes==
*[[Multiple myeloma]]
[[VWD]] is caused by a quantitative or qualitative defect in [[vWF]]. [[Von Willebrand Factor]] binds [[platelets]] to [[collagen]] and is important in primary [[hemostasis]].  It also serves as a carrier for [[Factor VIII]] and prevents it form being degraded.  Most cases of vWD are due to inherited mutations that affect production of vWF.  There are also acquired forms of vWD where vWF is impaired due to other pathological processes. Acquired defects in [[vWF]] can be caused by a number of conditions including:<ref name="pmid4172730">{{cite journal| author=Simone JV, Cornet JA, Abildgaard CF| title=Acquired von Willebrand's syndrome in systemic lupus erythematosus. | journal=Blood | year= 1968 | volume= 31 | issue= 6 | pages= 806-12 | pmid=4172730 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4172730  }} </ref><ref name="pmid1083062">{{cite journal| author=Wautier JL, Levy-Toledano S, Caen JP| title=Acquired von Willebrand's syndrome and thrombopathy in a patient with chronic lymphocytic leukaemia. | journal=Scand J Haematol | year= 1976 | volume= 16 | issue= 2 | pages= 128-34 | pmid=1083062 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1083062  }} </ref><ref name="pmid17133419">{{cite journal| author=Franchini M, Lippi G| title=Acquired von Willebrand syndrome: an update. | journal=Am J Hematol | year= 2007 | volume= 82 | issue= 5 | pages= 368-75 | pmid=17133419 | doi=10.1002/ajh.20830 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17133419  }} </ref><ref name="pmid21540459">{{cite journal| author=Tiede A, Rand JH, Budde U, Ganser A, Federici AB| title=How I treat the acquired von Willebrand syndrome. | journal=Blood | year= 2011 | volume= 117 | issue= 25 | pages= 6777-85 | pmid=21540459 | doi=10.1182/blood-2010-11-297580 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21540459  }} </ref><ref name="pmid11838652">{{cite journal| author=Kumar S, Pruthi RK, Nichols WL| title=Acquired von Willebrand disease. | journal=Mayo Clin Proc | year= 2002 | volume= 77 | issue= 2 | pages= 181-7 | pmid=11838652 | doi=10.4065/77.2.181 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11838652  }} </ref><ref name="pmid10959686">{{cite journal| author=Veyradier A, Jenkins CS, Fressinaud E, Meyer D| title=Acquired von Willebrand syndrome: from pathophysiology to management. | journal=Thromb Haemost | year= 2000 | volume= 84 | issue= 2 | pages= 175-82 | pmid=10959686 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10959686  }} </ref><ref name="pmid10959711">{{cite journal| author=Federici AB, Rand JH, Bucciarelli P, Budde U, van Genderen PJ, Mohri H et al.| title=Acquired von Willebrand syndrome: data from an international registry. | journal=Thromb Haemost | year= 2000 | volume= 84 | issue= 2 | pages= 345-9 | pmid=10959711 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10959711  }} </ref>
*[[Monoclonal gammopathy of undetermined significance]]
 
====Heart-related conditions====
 
*[[Mitral valve prolapse]]
*[[Mitral valve prolapse]]
*[[Non-Hodgkin lymphoma]]
*[[Polycythemia vera]]
*[[Uremia]]
*Ventricular assist device
*Ventricular assist device
*[[Ventricular septal defect]]
*[[Ventricular septal defect]]
*[[Aortic stenosis]]
*[[Valproic acid]]
 
====Malignant diseases====
*Monoclonal gammopathy of undetermined significance
 
*Leukemia example [[chronic myeloid leukemia]] and [[chronic lymphocytic leukemia]]
*[[Wilms tumor]]
*[[Wilms tumor]]
*[[Waldenström macroglobulinemia]]
*[[Waldenström macroglobulinemia]]
*[[Essential thrombocythemia]]
*
*[[Multiple myeloma]]
*[[Waldenström macroglobulinemia]]
*[[Non-Hodgkin lymphoma]]
*[[Polycythemia vera]]
 
====Drugs and other agents====
*[[Valproic acid]]
* [[Ciprofloxacin]]
*[[Griseofulvin]]


====Autoimmune disorders====
*[[Systemic lupus erythematosus]]


====Other disorders====
*[[Hypothyroidism]]
*[[Uremia]]
*[[Hemoglobinopathies]]
*[[Angiodysplasia]]


==References==
==References==

Latest revision as of 16:27, 28 September 2018

Von Willebrand disease Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Von Willebrand disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Von Willebrand disease causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Von Willebrand disease causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Von Willebrand disease causes

on Von Willebrand disease causes

Von Willebrand disease causes in the news

Blogs on Von Willebrand disease causes

Directions to Hospitals Treating Von Willebrand disease

Risk calculators and risk factors for Von Willebrand disease causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Prince Tano Djan, BSc, MBChB [2] Nazia Fuad M.D.

Overview

VWD is caused by a quantitative or qualitative defect in vWF. Most cases of vWD are due to inherited mutations that affect production of vWF. There are also acquired forms of vWD where vWF is impaired due to other pathological processes. Acquired defects in vWF can be caused by a number of conditions,for example mitral valve prolapse, ventricular assist device, ventricular septal defect, aortic stenosis, monoclonal gammopathy of undetermined significance, chronic myeloid leukemia and chronic lymphocytic leukemia, wilms tumor, waldenström macroglobulinemia, essential thrombocythemia, multiple myeloma, non-Hodgkin lymphoma, polycythemia vera, valproic acid, ciprofloxacin, griseofulvin, systemic lupus erythematosus,hypothyroidism, uremia, hemoglobinopathies and angiodysplasia.


Causes

Life-threatening Causes

  • There are no life-threatening causes of von willebrand disease.

Common Causes

Common causes of von willebrand disease may include:[1][2]

Less Common Causes

Less common causes of von Willebrand disease include:[3]

Genetic Causes

  • The vWF gene is located on the short arm p of chromosome 12 (12p13.2) von Willebrand disease is caused by a mutation in this gene.

Causes by Organ System

Cardiovascular
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect
Ear Nose Throat No underlying causes
Endocrine Hypothyroidism
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic Mutations in vWF gene
Hematologic
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte Wilms tumor
Rheumatology/Immunology/Allergy
Sexual No underlying causes
Trauma No underlying causes
Urologic Uremia
Miscellaneous No underlying causes

Causes in Alphabetical Order

List the causes of the disease in alphabetical order:


References

  1. ↑ Simone JV, Cornet JA, Abildgaard CF (1968). "Acquired von Willebrand's syndrome in systemic lupus erythematosus". Blood. 31 (6): 806–12. PMID 4172730.
  2. ↑ Wautier JL, Levy-Toledano S, Caen JP (1976). "Acquired von Willebrand's syndrome and thrombopathy in a patient with chronic lymphocytic leukaemia". Scand J Haematol. 16 (2): 128–34. PMID 1083062.
  3. ↑ Franchini M, Lippi G (2007). "Acquired von Willebrand syndrome: an update". Am J Hematol. 82 (5): 368–75. doi:10.1002/ajh.20830. PMID 17133419.

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Von_Willebrand_disease_causes&oldid=1495840"