Toxic shock syndrome natural history, complications and prognosis: Difference between revisions
Usama Talib (talk | contribs) |
|||
| Line 17: | Line 17: | ||
**[[ARDS]] | **[[ARDS]] | ||
* [[Shock]] | * [[Shock]] | ||
* Patients with initial soft tissue infection due to Group A Streptococci (GAS), presenting as toxic shock syndrome may deteriorate rapidly leading to [[necrotizing fasciitis]] and [[myositis]], which may give rise to a [[compartment syndrome]] with associated [[rhabdomyolysis]].<ref name="pmid8421863">{{cite journal |vauthors=Hasselbalch HC |title=[Toxic shock syndrome in group A streptococcal infection] |language=Danish |journal=Ugeskr. Laeg. |volume=155 |issue=2 |pages=74–8 |year=1993 |pmid=8421863 |doi= |url=}}</ref> | * Patients with initial soft tissue infection due to [[Streptococcus pyogenes|Group A Streptococci]] (GAS), presenting as toxic shock syndrome may deteriorate rapidly leading to [[necrotizing fasciitis]] and [[myositis]], which may give rise to a [[compartment syndrome]] with associated [[rhabdomyolysis]].<ref name="pmid8421863">{{cite journal |vauthors=Hasselbalch HC |title=[Toxic shock syndrome in group A streptococcal infection] |language=Danish |journal=Ugeskr. Laeg. |volume=155 |issue=2 |pages=74–8 |year=1993 |pmid=8421863 |doi= |url=}}</ref> | ||
===Prognosis=== | ===Prognosis=== | ||
* Patients with Toxic shock syndrome who are diagnosed early and given appropriate treatment often have a good prognosis. Early treatment can help prevent complications such as [http://www.medicinenet.com/kidney_failure/article.htm renal failure], respiratory failure, and coagulation disorders. However, the mortality (death) rate is about 5%-15%, and patients who develop complications have a poorer prognosis than those who do not. Patients who develop TSS are at risk for reinfection | * Patients with Toxic shock syndrome who are diagnosed early and given appropriate treatment often have a good prognosis. Early treatment can help prevent complications such as [http://www.medicinenet.com/kidney_failure/article.htm renal failure], respiratory failure, and coagulation disorders. However, the mortality (death) rate is about 5%-15%, and patients who develop complications have a poorer prognosis than those who do not. Patients who develop [[Toxic shock syndrome|TSS]] are at risk for reinfection | ||
* Some of the factors which may lead to a poor outcome for a patient suffering from toxic shock syndrome are: | * Some of the factors which may lead to a poor outcome for a patient suffering from toxic shock syndrome are:<ref name="pmid15380776">{{cite journal |vauthors=Hasegawa T, Hashikawa SN, Nakamura T, Torii K, Ohta M |title=Factors determining prognosis in streptococcal toxic shock-like syndrome: results of a nationwide investigation in Japan |journal=Microbes Infect. |volume=6 |issue=12 |pages=1073–7 |year=2004 |pmid=15380776 |doi=10.1016/j.micinf.2004.06.001 |url=}}</ref> | ||
** | ** Leukocytopenia | ||
** | ** Thrombocytopenia | ||
** | ** Hypotension | ||
** Low temperature | ** Low temperature | ||
** High blood [[creatinine]] levels | ** High blood [[creatinine]] levels | ||
==References== | ==References== | ||
Revision as of 21:18, 30 May 2017
|
Toxic shock syndrome Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Toxic shock syndrome natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Toxic shock syndrome natural history, complications and prognosis |
|
FDA on Toxic shock syndrome natural history, complications and prognosis |
|
CDC on Toxic shock syndrome natural history, complications and prognosis |
|
Toxic shock syndrome natural history, complications and prognosis in the news |
|
Blogs on Toxic shock syndrome natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
If left untreated toxic shock syndrome after initial presentation, may rapidly lead to multiorgan system failure with serious morbidity and mortality. Appropriate treatment leads to full recovery of the patient.
Natural History, Complications and Prognosis
During the early phase of development of Toxic shock syndrome (TSS), the patient will develop severe flu-like symptoms such as a high fever, vomiting, a sun-burn like rash, muscle aches and general weakness. If left untreated, these symptoms may progress to hypotension, tachycardia, high grade fever, diarrhoea, vomiting, irritability, drowsiness and eventually organ faliure. Early recognition and aggressive management can decrease the overall morbidity and mortality of toxic shock syndrome.
Complications
Toxic shock syndrome (TSS) may lead to the following complications:
- Severe organ dysfunction
- Shock
- Patients with initial soft tissue infection due to Group A Streptococci (GAS), presenting as toxic shock syndrome may deteriorate rapidly leading to necrotizing fasciitis and myositis, which may give rise to a compartment syndrome with associated rhabdomyolysis.[1]
Prognosis
- Patients with Toxic shock syndrome who are diagnosed early and given appropriate treatment often have a good prognosis. Early treatment can help prevent complications such as renal failure, respiratory failure, and coagulation disorders. However, the mortality (death) rate is about 5%-15%, and patients who develop complications have a poorer prognosis than those who do not. Patients who develop TSS are at risk for reinfection
- Some of the factors which may lead to a poor outcome for a patient suffering from toxic shock syndrome are:[2]
- Leukocytopenia
- Thrombocytopenia
- Hypotension
- Low temperature
- High blood creatinine levels
References
- ↑ Hasselbalch HC (1993). "[Toxic shock syndrome in group A streptococcal infection]". Ugeskr. Laeg. (in Danish). 155 (2): 74–8. PMID 8421863.
- ↑ Hasegawa T, Hashikawa SN, Nakamura T, Torii K, Ohta M (2004). "Factors determining prognosis in streptococcal toxic shock-like syndrome: results of a nationwide investigation in Japan". Microbes Infect. 6 (12): 1073–7. doi:10.1016/j.micinf.2004.06.001. PMID 15380776.