Tongue cancer staging: Difference between revisions

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==Staging==
==Staging==
A common staging system is used for all [[squamous cell carcinomas]] of the [[oral cavity]], with [[tumor]] staging being based on size and extension into adjacent structures. Nodal staging is the same as that used for squamous cell carcinomas of the [[oral cavity]], [[oropharynx]], [[hypopharynx]] and [[larynx]].<ref name="radio">  Sqamous cell carcinoma of the tongue. Radiopedia(2015) http://radiopaedia.org/articles/squamous-cell-carcinoma-of-the-tongue Accessed on November 17, 2015</ref> The following features are assessed on either CT or MRI:<ref name="pmid8835972">{{cite journal| author=Sigal R, Zagdanski AM, Schwaab G, Bosq J, Auperin A, Laplanche A et al.| title=CT and MR imaging of squamous cell carcinoma of the tongue and floor of the mouth. | journal=Radiographics | year= 1996 | volume= 16 | issue= 4 | pages= 787-810 | pmid=8835972 | doi=10.1148/radiographics.16.4.8835972 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8835972  }} </ref>
The TNM classification of oral cavity carcinoma is as follows:<ref>{{cite book | last = Sobin | first = L. H. | title = TNM classification of malignant tumours | publisher = Wiley-Blackwell | location = Chichester, West Sussex, UK Hoboken, NJ | year = 2009 | isbn = 9781444332414 }}</ref>
*Size of tumor and tumor thickness
{| class="wikitable"
*Extension across the midline
! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |TNM Staging for Lip and Oral Cavity Cancers#
*Extension beyond the intrinsic muscles of the tongue
*Involvement of adjacent structures
**Neurovascular bundle and [[submandibular duct]] in the floor of mouth
**[[Mandible]]
===T Categories for tongue cancer===
{| style="border: 0px; font-size: 90%; margin: 3px; width: 800px" align=center
|valign=top|
|+
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|T Classification}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Thickness}}
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| colspan="2" |'''Tumor'''
:TX
| style="padding: 5px 5px; background: #F5F5F5;" |Primary tumor cannot be assessed
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|TX
:T0
|[[Primary tumor]] cannot be assessed.
| style="padding: 5px 5px; background: #F5F5F5;" |No evidence of a primary tumor
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|T0
:Tis
|[[Primary tumor]] cannot be assessed.
| style="padding: 5px 5px; background: #F5F5F5;" |Carcinoma in situ
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|Tis
:T1
|[[Carcinoma in situ]]
| style="padding: 5px 5px; background: #F5F5F5;" |Tumor ≤2 cm in greatest dimension
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|T1
:T2
|[[Tumor]] <2 cm or less in greatest dimension
| style="padding: 5px 5px; background: #F5F5F5;" |Tumor >2 cm but ≤4 cm in greatest dimension
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
|T2
:T3
|[[Tumor]] more than 2 cm but not more than 4 cm in greatest dimension
| style="padding: 5px 5px; background: #F5F5F5;" |Tumor >4 cm in greatest dimension
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
|T3
:T4a
|[[Tumor]] more than 4 cm in greatest dimension
| style="padding: 5px 5px; background: #F5F5F5;" |Moderately advanced local disease
*(Lip) Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, that is, chin or nose
*(Oral cavity) Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, or skin of face) '''b'''
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
|T4 (lip)
:T4b
|[[Tumor]] invades through cortical bone, [[inferior alveolar nerve]], floor of the mouth, or [[skin]] of the face (e.g., chin or nose).
| style="padding: 5px 5px; background: #F5F5F5;" |Very advanced local disease.
*Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery
|-
|-
|}
|T4a (oral cavity)
'''b''' Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of larynx.
|[[Tumor]] invades adjacent structures (e.g., through cortical bone into deep [extrinsic] [[muscle]] of the [[tongue]] [[[genioglossus]], [[hyoglossus]], [[palatoglossus]], and [[styloglossus]]], [[maxillary sinus]], or [[skin]] of the [[face]]).
 
|-
===N Categories for tongue cancer '''b'''===
|T4b
Lymphatic drainage of the tongue is extensive, accounting presumably for the high rate of nodal metastases present at the time of diagnosis. Drainage patterns depend on the location of the primary lesion:
|[[Tumor]] invades masticator space, [[pterygoid]] plates, or skull base and/or encases [[internal carotid]] canal.
*Anterior tongue: level Ia nodes ([[submental]] nodes)
|-
*Lateral tongue
| colspan="2" |'''Regional Lymph Nodes (N)'''
*Level Ib nodes: [[submandibular]]
 
*Level II nodes: upper jugulodigastic nodes
*Potentially drain directly to level IV nodes
*Posterior tongue: level II nodes (upper jugulodigastic nodes)
It is important to remember that significant lymphatic drainage occurs across the midline, and thus the nodes of both sides of the neck need to be carefully examined for presence of nodal metastases. The incidence of [[lymph node]] [[metastases]] correlates with tumor thickness, which is best assessed on coronal images
 
{| style="border: 0px; font-size: 90%; margin: 3px; width: 800px" align=center
|valign=top|
|+
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|N Classification}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Nodal Mass}}
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|NX
:NX
|Regional [[lymph nodes]] cannot be assessed
| style="padding: 5px 5px; background: #F5F5F5;" |Regional lymph nodes cannot be assessed
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|N0
:N0
|No regional [[lymph node]] [[metastasis]]
| style="padding: 5px 5px; background: #F5F5F5;" |No regional lymph node metastasis
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|N1
:N1
|[[Metastasis]] in a single [[ipsilateral]] [[lymph node]], 3 cm or less in greatest dimension
| style="padding: 5px 5px; background: #F5F5F5;" |Metastasis in a single ipsilateral lymph node, ≤3 cm in greatest dimension
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|N2a
:N2
|[[Metastasis]] in a single [[ipsilateral]] [[lymph node]], more than 3 cm but not more than 6 cm in greatest dimension
| style="padding: 5px 5px; background: #F5F5F5;" |
*Metastasis in a single ipsilateral lymph node, >3 cm but ≤6 cm in greatest dimension
*Metastases in multiple ipsilateral lymph nodes, none >6 cm in greatest dimension
*Metastases in bilateral or contralateral lymph nodes, none >6 cm in greatest dimension
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|N2b
:N2a
|[[Metastasis]] in multiple [[ipsilateral]] [[lymph nodes]], none more than 6 cm in greatest dimension
| style="padding: 5px 5px; background: #F5F5F5;" |Metastasis in single ipsilateral lymph node, >3 cm but ≤6 cm in greatest dimension
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
|N2c
:N2b
|[[Metastasis]] in bilateral or [[contralateral]] [[lymph nodes]], none more than 6 cm in greatest dimension
| style="padding: 5px 5px; background: #F5F5F5;" |Metastases in multiple ipsilateral lymph nodes, none >6 cm in greatest dimension
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
|N3
:N2c
|[[Metastasis]] in a [[lymph node]] more than 6 cm in greatest dimension
| style="padding: 5px 5px; background: #F5F5F5;" |Metastases in bilateral or contralateral lymph nodes, none >6 cm in greatest dimension
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
| colspan="2" |'''Distant Metastasis (M)'''
:N3
| style="padding: 5px 5px; background: #F5F5F5;" |Metastasis in a lymph node >6 cm in greatest dimension
|-
|-
|}
|MX
'''b''' Metastases at level VII are considered regional lymph node metastases
|Distant [[metastasis]] cannot be assessed
 
===M Categories for tongue cancer===
{| style="border: 0px; font-size: 90%; margin: 3px; width: 300px" align=center
|valign=top|
|+
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|M Classification}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Definition}}
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|M0
:M0
|No distant [[metastasis]]
| style="padding: 5px 5px; background: #F5F5F5;" |No distant metastasis
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|M1
:M1
|Distant [[metastasis]]
| style="padding: 5px 5px; background: #F5F5F5;" |Distant metastasis
|-
|-
| colspan="2" |M = Distant [[metastasis]]; N = regional [[Lymph node|lymph nodes]]; T= [[primary tumor]]; Tis = [[carcinoma in situ]].
<nowiki>#</nowiki> = Staging system of the American Joint Committee on Cancer.
|}
|}
 
{| class="wikitable"
===Stages of tongue cancer===
! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Staging of Oral Squamous Cell Carcinoma
{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
|-
|valign=top|
|'''Stage'''
|+
|'''Description'''
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''Stage'''}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''T'''}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''N'''}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''M'''}}
|-
|-
| style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|0
:Stage 0
|Tis, N0, M0
| style="padding: 5px 5px; background: #F5F5F5;" |
*Tis
| style="padding: 5px 5px; background: #F5F5F5;" |
*N0
| style="padding: 5px 5px; background: #F5F5F5;" |
*M0
|-
|-
| style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|I
:Stage I
|T1, N0, M0
| style="padding: 5px 5px; background: #F5F5F5;" |
*T1
| style="padding: 5px 5px; background: #F5F5F5;" |
*N0
| style="padding: 5px 5px; background: #F5F5F5;" |
*M0
|-
|-
| style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|II
:Stage II
|T2, N0, M0
| style="padding: 5px 5px; background: #F5F5F5;" |
*T2b
| style="padding: 5px 5px; background: #F5F5F5;" |
*N0
| style="padding: 5px 5px; background: #F5F5F5;" |
*M0
|-
|-
| style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|III
:Stage III
|T3, N0, M0
| style="padding: 5px 5px; background: #F5F5F5;" |
T1, N1, M0
*T3
 
*T2
T2, N1, M0
*T1
 
*T3
T3, N1, M0
| style="padding: 5px 5px; background: #F5F5F5;" |
*N0
*N1
*N1
*N1
| style="padding: 5px 5px; background: #F5F5F5;" |
*M0
*M0
*M0
*M0
|-
|-
| style="text-align: center;padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
|IVA
:Stage IVA
|T4a, N0, M0
| style="padding: 5px 5px; background: #F5F5F5;" |
T4a, N1, M0
*T4a
 
*T4a
T1, N2, M0
*T1
 
*T2
T2, N2, M0
*T3
 
*T4a
T3, N2, M0
| style="padding: 5px 5px; background: #F5F5F5;" |
 
*N0
T4a, N2, M0
*N1
*N2
*N2
*N2
*N2
| style="padding: 5px 5px; background: #F5F5F5;" |
*M0
*M0
*M0
*M0
*M0
*M0
|-
|-
| style="text-align: center;padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
|IVB
:Stage IVB
|Any T, N3, M0
| style="padding: 5px 5px; background: #F5F5F5;" |
T4b, any N, M0
*Any T
*T4b
| style="padding: 5px 5px; background: #F5F5F5;" |
*N3
*Any N
| style="padding: 5px 5px; background: #F5F5F5;" |
*M0
*M0
|-
|-
| style="text-align: center;padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
|IVC
:Stage IVC
|Any T, any N, M1
| style="padding: 5px 5px; background: #F5F5F5;" |
*Any T
| style="padding: 5px 5px; background: #F5F5F5;" |
*Any N
| style="padding: 5px 5px; background: #F5F5F5;" |
*M1
|-
|-
| colspan="2" |M = Distant [[metastasis]]; N = regional [[lymph nodes]]; T = [[primary tumor]]; Tis = [[carcinoma in situ]].
|}
|}



Revision as of 21:12, 5 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2] Mohammed Abdelwahed M.D[3]

Overview

According to the TNM staging system by the American Joint Committee on Cancer, there are four stages of oral cancer based on the tumor size, lymph nodes involved, and metastasis.[1][2]

Staging

The TNM classification of oral cavity carcinoma is as follows:[3]

TNM Staging for Lip and Oral Cavity Cancers#
Tumor
TX Primary tumor cannot be assessed.
T0 Primary tumor cannot be assessed.
Tis Carcinoma in situ
T1 Tumor <2 cm or less in greatest dimension
T2 Tumor more than 2 cm but not more than 4 cm in greatest dimension
T3 Tumor more than 4 cm in greatest dimension
T4 (lip) Tumor invades through cortical bone, inferior alveolar nerve, floor of the mouth, or skin of the face (e.g., chin or nose).
T4a (oral cavity) Tumor invades adjacent structures (e.g., through cortical bone into deep [extrinsic] muscle of the tongue [[[genioglossus]], hyoglossus, palatoglossus, and styloglossus], maxillary sinus, or skin of the face).
T4b Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid canal.
Regional Lymph Nodes (N)
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node metastasis
N1 Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension
N2a Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension
N2b Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension
N2c Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension
N3 Metastasis in a lymph node more than 6 cm in greatest dimension
Distant Metastasis (M)
MX Distant metastasis cannot be assessed
M0 No distant metastasis
M1 Distant metastasis
M = Distant metastasis; N = regional lymph nodes; T= primary tumor; Tis = carcinoma in situ.

# = Staging system of the American Joint Committee on Cancer.

Staging of Oral Squamous Cell Carcinoma
Stage Description
0 Tis, N0, M0
I T1, N0, M0
II T2, N0, M0
III T3, N0, M0

T1, N1, M0

T2, N1, M0

T3, N1, M0

IVA T4a, N0, M0

T4a, N1, M0

T1, N2, M0

T2, N2, M0

T3, N2, M0

T4a, N2, M0

IVB Any T, N3, M0

T4b, any N, M0

IVC Any T, any N, M1
M = Distant metastasis; N = regional lymph nodes; T = primary tumor; Tis = carcinoma in situ.

References

  1. Sqamous cell carcinoma of the tongue. Radiopedia(2015) http://radiopaedia.org/articles/squamous-cell-carcinoma-of-the-tongue Accessed on November 17, 2015
  2. Staging of Sqamous cell carcinoma of the oral cavity. Radiopedia(2015) http://radiopaedia.org/articles/staging-of-squamous-cell-carcinoma-of-the-oral-cavity Accessed on November 17, 2015
  3. Sobin, L. H. (2009). TNM classification of malignant tumours. Chichester, West Sussex, UK Hoboken, NJ: Wiley-Blackwell. ISBN 9781444332414.

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