Thyroid hormone receptor alpha

Thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
File:PBB Protein THRA image.jpg PDB rendering based on 1nav.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1nav​, 2h77​, 2h79​
Identifiers
Symbols	THRA ; AR7; EAR7; ERB-T-1; ERBA; ERBA1; MGC000261; MGC43240; NR1A1; THRA1; THRA2; c-ERBA-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37747
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE THRA 35846 at tn.png
File:PBB GE THRA 204100 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Thyroid hormone receptor alpha (TR-alpha) (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), also known as NR1A1 (nuclear receptor subfamily 1, group A, member 1), is nuclear receptor protein encoded by the THRA gene.

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Further reading

• Forrest D, Reh TA, Rüsch A (2002). "Neurodevelopmental control by thyroid hormone receptors". Curr. Opin. Neurobiol. 12 (1): 49–56. PMID 11861164.CS1 maint: Multiple names: authors list (link)
• Sakurai A, Bell GI, DeGroot LJ (1993). "Dinucleotide repeat polymorphism in the human thyroid hormone receptor alpha gene (THRA1) on chromosome 17". Hum. Mol. Genet. 1 (7): 553. PMID 1307263.CS1 maint: Multiple names: authors list (link)
• Berrodin TJ, Marks MS, Ozato K; et al. (1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein". Mol. Endocrinol. 6 (9): 1468–78. PMID 1331778.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmidt ED, Schmidt ED, van der Gaag R; et al. (1992). "Distribution of the nuclear thyroid-hormone receptor in extraocular and skeletal muscles". J. Endocrinol. 133 (1): 67–74. PMID 1517709.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yen PM, Sunday ME, Darling DS, Chin WW (1992). "Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries". Endocrinology. 130 (3): 1539–46. PMID 1537303.CS1 maint: Multiple names: authors list (link)
• Laudet V, Begue A, Henry-Duthoit C; et al. (1991). "Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene". Nucleic Acids Res. 19 (5): 1105–12. PMID 1850510.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakai A, Sakurai A, Bell GI, DeGroot LJ (1989). "Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues". Mol. Endocrinol. 2 (11): 1087–92. PMID 2464749.CS1 maint: Multiple names: authors list (link)
• Miyajima N, Horiuchi R, Shibuya Y; et al. (1989). "Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus". Cell. 57 (1): 31–9. PMID 2539258.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakurai A, Nakai A, DeGroot LJ (1989). "Expression of three forms of thyroid hormone receptor in human tissues". Mol. Endocrinol. 3 (2): 392–9. PMID 2710139.CS1 maint: Multiple names: authors list (link)
• Sap J, Muñoz A, Damm K; et al. (1987). "The c-erb-A protein is a high-affinity receptor for thyroid hormone". Nature. 324 (6098): 635–40. doi:10.1038/324635a0. PMID 2879242.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakai A, Seino S, Sakurai A; et al. (1988). "Characterization of a thyroid hormone receptor expressed in human kidney and other tissues". Proc. Natl. Acad. Sci. U.S.A. 85 (8): 2781–5. PMID 3357890.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mitelman F, Manolov G, Manolova Y; et al. (1986). "High resolution chromosome analysis of constitutional and acquired t(15;17) maps c-erbA to subband 17q11.2". Cancer Genet. Cytogenet. 22 (2): 95–8. PMID 3458521.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Benbrook D, Pfahl M (1987). "A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library". Science. 238 (4828): 788–91. PMID 3672126.
• Pfahl M, Benbrook D (1988). "Nucleotide sequence of cDNA encoding a novel human thyroid hormone receptor". Nucleic Acids Res. 15 (22): 9613. PMID 3684612.
• Spurr NK, Solomon E, Jansson M; et al. (1984). "Chromosomal localisation of the human homologues to the oncogenes erbA and B.". EMBO J. 3 (1): 159–63. PMID 6323162.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dayton AI, Selden JR, Laws G; et al. (1984). "A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. 81 (14): 4495–9. PMID 6589608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen JD, Evans RM (1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors". Nature. 377 (6548): 454–7. doi:10.1038/377454a0. PMID 7566127.
• Desai-Yajnik V, Hadzic E, Modlinger P; et al. (1995). "Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator". J. Virol. 69 (8): 5103–12. PMID 7609079.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee JW, Choi HS, Gyuris J; et al. (1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol. Endocrinol. 9 (2): 243–54. PMID 7776974.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Desai-Yajnik V, Samuels HH (1994). "Regulation of the human immunodeficiency virus type 1 long terminal repeat: interactions of thyroid hormone receptor with retinoid-X receptor, nuclear factor kappa B, Sp1, and Tat". Trans. Assoc. Am. Physicians. 106: 13–32. PMID 8036737.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.