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Our knowledge about the origins of thalassemia date back to more than 5000 years ago. | Our knowledge about the origins of thalassemia date back to more than 5000 years ago. | ||
*In '''4000 B.C.''', persons of eastern Mediterranean descent migrated to Sicily, carrying thalassemia gene variants with them.<ref name="pmid28293406">{{cite journal| author=De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M et al.| title=β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint. | journal=Mediterr J Hematol Infect Dis | year= 2017 | volume= 9 | issue= 1 | pages= e2017018 | pmid=28293406 | doi=10.4084/MJHID.2017.018 | pmc=5333734 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28293406 }} </ref> | *In '''4000 B.C.''', persons of eastern Mediterranean descent migrated to Sicily, carrying thalassemia gene variants with them.<ref name="pmid28293406">{{cite journal| author=De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M et al.| title=β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint. | journal=Mediterr J Hematol Infect Dis | year= 2017 | volume= 9 | issue= 1 | pages= e2017018 | pmid=28293406 | doi=10.4084/MJHID.2017.018 | pmc=5333734 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28293406 }} </ref> | ||
*In the '''800s-900s | *In the '''800s-900s''', there was mass migration of Arabs. | ||
*In the 1400s-1500s, there was further influx of beta-thalassemia mutations with the expansion of the Ottoman Empire.<ref name="pmid28293406">{{cite journal| author=De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M et al.| title=β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint. | journal=Mediterr J Hematol Infect Dis | year= 2017 | volume= 9 | issue= 1 | pages= e2017018 | pmid=28293406 | doi=10.4084/MJHID.2017.018 | pmc=5333734 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28293406 }} </ref> The Ottoman Expire expanded Eastern Europe, Central Asia, and Northern Africa. | *In the '''1400s-1500s''', there was further influx of beta-thalassemia mutations with the expansion of the Ottoman Empire.<ref name="pmid28293406">{{cite journal| author=De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M et al.| title=β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint. | journal=Mediterr J Hematol Infect Dis | year= 2017 | volume= 9 | issue= 1 | pages= e2017018 | pmid=28293406 | doi=10.4084/MJHID.2017.018 | pmc=5333734 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28293406 }} </ref> The Ottoman Expire expanded Eastern Europe, Central Asia, and Northern Africa. | ||
*In '''1952''', Silvestroni and colleagues note that beta-thalassemia trait was highly prevalent in the Po River's delta region.<ref name="pmid28293406">{{cite journal| author=De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M et al.| title=β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint. | journal=Mediterr J Hematol Infect Dis | year= 2017 | volume= 9 | issue= 1 | pages= e2017018 | pmid=28293406 | doi=10.4084/MJHID.2017.018 | pmc=5333734 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28293406 }} </ref> | *In '''1952''', Silvestroni and colleagues note that beta-thalassemia trait was highly prevalent in the Po River's delta region.<ref name="pmid28293406">{{cite journal| author=De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M et al.| title=β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint. | journal=Mediterr J Hematol Infect Dis | year= 2017 | volume= 9 | issue= 1 | pages= e2017018 | pmid=28293406 | doi=10.4084/MJHID.2017.018 | pmc=5333734 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28293406 }} </ref> | ||
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Overview
Historical Perspective
Our knowledge about the origins of thalassemia date back to more than 5000 years ago.
- In 4000 B.C., persons of eastern Mediterranean descent migrated to Sicily, carrying thalassemia gene variants with them.[1]
- In the 800s-900s, there was mass migration of Arabs.
- In the 1400s-1500s, there was further influx of beta-thalassemia mutations with the expansion of the Ottoman Empire.[1] The Ottoman Expire expanded Eastern Europe, Central Asia, and Northern Africa.
- In 1952, Silvestroni and colleagues note that beta-thalassemia trait was highly prevalent in the Po River's delta region.[1]
References
- ↑ 1.0 1.1 1.2 De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M; et al. (2017). "β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint". Mediterr J Hematol Infect Dis. 9 (1): e2017018. doi:10.4084/MJHID.2017.018. PMC 5333734. PMID 28293406.