TINF2: Difference between revisions

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Latest revision as of 06:26, 10 January 2019

TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene.^[1]^[2] TIN2 is a component of the shelterin protein complex found at the end of telomeres.^[3]

Interactions

TINF2 has been shown to interact with ACD,^[4]^[5] POT1^[4]^[5]^[6] and TERF1.^[1]^[5]^[7]

References

↑ ^1.0 ^1.1 Kim SH, Kaminker P, Campisi J (Dec 1999). "TIN2, a new regulator of telomere length in human cells". Nature Genetics. 23 (4): 405–12. doi:10.1038/70508. PMC 4940194. PMID 10581025.
↑ "Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2".
↑ Savage SA, Giri N, Baerlocher GM, Orr N, Lansdorp PM, Alter BP (Feb 2008). "TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita". American Journal of Human Genetics. 82 (2): 501–9. doi:10.1016/j.ajhg.2007.10.004. PMC 2427222. PMID 18252230.
↑ ^4.0 ^4.1 Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T (Jul 2004). "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex". Genes & Development. 18 (14): 1649–54. doi:10.1101/gad.1215404. PMC 478187. PMID 15231715.
↑ ^5.0 ^5.1 ^5.2 Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology. 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449.
↑ Loayza D, De Lange T (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature. 423 (6943): 1013–8. doi:10.1038/nature01688. PMID 12768206.
↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Li B, Oestreich S, de Lange T (May 2000). "Identification of human Rap1: implications for telomere evolution". Cell. 101 (5): 471–83. doi:10.1016/S0092-8674(00)80858-2. PMID 10850490.
Mignon-Ravix C, Depetris D, Delobel B, Croquette MF, Mattei MG (Feb 2002). "A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins". European Journal of Human Genetics. 10 (2): 107–12. doi:10.1038/sj.ejhg.5200775. PMID 11938440.
Yamada M, Tsuji N, Nakamura M, Moriai R, Kobayashi D, Yagihashi A, Watanabe N (2003). "Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers". Anticancer Research. 22 (6A): 3303–7. PMID 12530079.
Loayza D, De Lange T (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature. 423 (6943): 1013–8. doi:10.1038/nature01688. PMID 12768206.
Kim SH, Han S, You YH, Chen DJ, Campisi J (Jul 2003). "The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro". EMBO Reports. 4 (7): 685–91. doi:10.1038/sj.embor.embor872. PMC 1326318. PMID 12835755.
Loayza D, Parsons H, Donigian J, Hoke K, de Lange T (Mar 2004). "DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites". The Journal of Biological Chemistry. 279 (13): 13241–8. doi:10.1074/jbc.M312309200. PMID 14715659.
Ye JZ, de Lange T (Jun 2004). "TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex". Nature Genetics. 36 (6): 618–23. doi:10.1038/ng1360. PMID 15133513.
Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology. 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449.
Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T (Jul 2004). "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex". Genes & Development. 18 (14): 1649–54. doi:10.1101/gad.1215404. PMC 478187. PMID 15231715.
Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J (Oct 2004). "TIN2 mediates functions of TRF2 at human telomeres". The Journal of Biological Chemistry. 279 (42): 43799–804. doi:10.1074/jbc.M408650200. PMID 15292264.
Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, Chait BT, de Lange T (Nov 2004). "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres". The Journal of Biological Chemistry. 279 (45): 47264–71. doi:10.1074/jbc.M409047200. PMID 15316005.
Liu D, O'Connor MS, Qin J, Songyang Z (Dec 2004). "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins". The Journal of Biological Chemistry. 279 (49): 51338–42. doi:10.1074/jbc.M409293200. PMID 15383534.
Oh BK, Kim YJ, Park C, Park YN (Jan 2005). "Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis". The American Journal of Pathology. 166 (1): 73–80. doi:10.1016/S0002-9440(10)62233-X. PMC 1602303. PMID 15632001.
Kaminker P, Plachot C, Kim SH, Chung P, Crippen D, Petersen OW, Bissell MJ, Campisi J, Lelièvre SA (Mar 2005). "Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2". Journal of Cell Science. 118 (Pt 6): 1321–30. doi:10.1242/jcs.01709. PMC 2933191. PMID 15741234.

External links

GeneReviews/NCBI/NIH/UW entry on Dyskeratosis Congenita

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[pmid10581025-1] 1.0 ^1.1 Kim SH, Kaminker P, Campisi J (Dec 1999). "TIN2, a new regulator of telomere length in human cells". Nature Genetics. 23 (4): 405–12. doi:10.1038/70508. PMC 4940194. PMID 10581025.

[entrez-2] "Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2".

[pmid18252230-3] Savage SA, Giri N, Baerlocher GM, Orr N, Lansdorp PM, Alter BP (Feb 2008). "TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita". American Journal of Human Genetics. 82 (2): 501–9. doi:10.1016/j.ajhg.2007.10.004. PMC 2427222. PMID 18252230.

[pmid15231715-4] 4.0 ^4.1 Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T (Jul 2004). "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex". Genes & Development. 18 (14): 1649–54. doi:10.1101/gad.1215404. PMC 478187. PMID 15231715.

[pmid15181449-5] 5.0 ^5.1 ^5.2 Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology. 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449.

[pmid12768206-6] Loayza D, De Lange T (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature. 423 (6943): 1013–8. doi:10.1038/nature01688. PMID 12768206.

[pmid16169070-7] Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''TERF1-interacting nuclear factor 2''' is a [[protein]] that in humans is encoded by the ''TINF2'' [[gene]].<ref name="pmid10581025">{{cite journal | vauthors = Kim SH, Kaminker P, Campisi J | title = TIN2, a new regulator of telomere length in human cells | journal = Nature Genetics | volume = 23 | issue = 4 | pages = 405–12 | date = Dec 1999 | pmid = 10581025 | pmc =  4940194| doi = 10.1038/70508 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26277| accessdate = }}</ref> TIN2 is a component of the [[shelterin]] protein complex found at the end of [[telomere]]s.<ref name="pmid18252230">{{cite journal | vauthors = Savage SA, Giri N, Baerlocher GM, Orr N, Lansdorp PM, Alter BP | title = TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita | journal = American Journal of Human Genetics | volume = 82 | issue = 2 | pages = 501–9 | date = Feb 2008 | pmid = 18252230 | pmc = 2427222 | doi = 10.1016/j.ajhg.2007.10.004 }}</ref>
-| update_page = yes
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-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = TERF1 (TRF1)-interacting nuclear factor 2
- | HGNCid = 11824
- | Symbol = TINF2
- | AltSymbols =; TIN2
- | OMIM = 604319
- | ECnumber =
- | Homologene = 8264
- | MGIid = 107246
- | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042162 |text = telomeric DNA binding}}
- | Component = {{GNF_GO|id=GO:0000781 |text = chromosome, telomeric region}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
- | Process = {{GNF_GO|id=GO:0007004 |text = telomere maintenance via telomerase}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 26277
-    | Hs_Ensembl = ENSG00000092330
-    | Hs_RefseqProtein = NP_036593
-    | Hs_RefseqmRNA = NM_012461
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 14
-    | Hs_GenLoc_start = 23778843
-    | Hs_GenLoc_end = 23781706
-    | Hs_Uniprot = Q9BSI4
-    | Mm_EntrezGene = 28113
-    | Mm_Ensembl = ENSMUSG00000007589
-    | Mm_RefseqmRNA = NM_145705
-    | Mm_RefseqProtein = NP_663751
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 14
-    | Mm_GenLoc_start = 54631266
-    | Mm_GenLoc_end = 54635891
-    | Mm_Uniprot = Q8CJ45
-  }}
-}}
-'''TERF1 (TRF1)-interacting nuclear factor 2''', also known as '''TINF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26277| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+TINF2 has been shown to [[Protein-protein interaction|interact]] with [[ACD (gene)|ACD]],<ref name=pmid15231715>{{cite journal | vauthors = Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T | title = POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex | journal = Genes & Development | volume = 18 | issue = 14 | pages = 1649–54 | date = Jul 2004 | pmid = 15231715 | pmc = 478187 | doi = 10.1101/gad.1215404 }}</ref><ref name=pmid15181449>{{cite journal | vauthors = Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z | title = PTOP interacts with POT1 and regulates its localization to telomeres | journal = Nature Cell Biology | volume = 6 | issue = 7 | pages = 673–80 | date = Jul 2004 | pmid = 15181449 | doi = 10.1038/ncb1142 }}</ref> [[POT1]]<ref name=pmid15231715/><ref name=pmid15181449/><ref name=pmid12768206>{{cite journal | vauthors = Loayza D, De Lange T | title = POT1 as a terminal transducer of TRF1 telomere length control | journal = Nature | volume = 423 | issue = 6943 | pages = 1013–8 | date = Jun 2003 | pmid = 12768206 | doi = 10.1038/nature01688 }}</ref> and [[TERF1]].<ref name=pmid10581025 /><ref name=pmid15181449/><ref name=pmid16169070>{{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}</ref>
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
-| citations =
+* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+* {{cite journal | vauthors = Li B, Oestreich S, de Lange T | title = Identification of human Rap1: implications for telomere evolution | journal = Cell | volume = 101 | issue = 5 | pages = 471–83 | date = May 2000 | pmid = 10850490 | doi = 10.1016/S0092-8674(00)80858-2 }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+* {{cite journal | vauthors = Mignon-Ravix C, Depetris D, Delobel B, Croquette MF, Mattei MG | title = A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins | journal = European Journal of Human Genetics | volume = 10 | issue = 2 | pages = 107–12 | date = Feb 2002 | pmid = 11938440 | doi = 10.1038/sj.ejhg.5200775 }}
-*{{cite journal  | author=Kim SH, Kaminker P, Campisi J |title=TIN2, a new regulator of telomere length in human cells. |journal=Nat. Genet. |volume=23 |issue= 4 |pages= 405-12 |year= 1999 |pmid= 10581025 |doi= 10.1038/70508 }}
+* {{cite journal | vauthors = Yamada M, Tsuji N, Nakamura M, Moriai R, Kobayashi D, Yagihashi A, Watanabe N | title = Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers | journal = Anticancer Research | volume = 22 | issue = 6A | pages = 3303–7 | year = 2003 | pmid = 12530079 | doi =  }}
-*{{cite journal  | author=Li B, Oestreich S, de Lange T |title=Identification of human Rap1: implications for telomere evolution. |journal=Cell |volume=101 |issue= 5 |pages= 471-83 |year= 2000 |pmid= 10850490 |doi=  }}
+* {{cite journal | vauthors = Loayza D, De Lange T | title = POT1 as a terminal transducer of TRF1 telomere length control | journal = Nature | volume = 423 | issue = 6943 | pages = 1013–8 | date = Jun 2003 | pmid = 12768206 | doi = 10.1038/nature01688 }}
-*{{cite journal  | author=Mignon-Ravix C, Depetris D, Delobel B, ''et al.'' |title=A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins. |journal=Eur. J. Hum. Genet. |volume=10 |issue= 2 |pages= 107-12 |year= 2002 |pmid= 11938440 |doi= 10.1038/sj.ejhg.5200775 }}
+* {{cite journal | vauthors = Kim SH, Han S, You YH, Chen DJ, Campisi J | title = The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro | journal = EMBO Reports | volume = 4 | issue = 7 | pages = 685–91 | date = Jul 2003 | pmid = 12835755 | pmc = 1326318 | doi = 10.1038/sj.embor.embor872 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Loayza D, Parsons H, Donigian J, Hoke K, de Lange T | title = DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites | journal = The Journal of Biological Chemistry | volume = 279 | issue = 13 | pages = 13241–8 | date = Mar 2004 | pmid = 14715659 | doi = 10.1074/jbc.M312309200 }}
-*{{cite journal  | author=Yamada M, Tsuji N, Nakamura M, ''et al.'' |title=Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers. |journal=Anticancer Res. |volume=22 |issue= 6A |pages= 3303-7 |year= 2003 |pmid= 12530079 |doi=  }}
+* {{cite journal | vauthors = Ye JZ, de Lange T | title = TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex | journal = Nature Genetics | volume = 36 | issue = 6 | pages = 618–23 | date = Jun 2004 | pmid = 15133513 | doi = 10.1038/ng1360 }}
-*{{cite journal  | author=Loayza D, De Lange T |title=POT1 as a terminal transducer of TRF1 telomere length control. |journal=Nature |volume=423 |issue= 6943 |pages= 1013-8 |year= 2003 |pmid= 12768206 |doi= 10.1038/nature01688 }}
+* {{cite journal | vauthors = Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z | title = PTOP interacts with POT1 and regulates its localization to telomeres | journal = Nature Cell Biology | volume = 6 | issue = 7 | pages = 673–80 | date = Jul 2004 | pmid = 15181449 | doi = 10.1038/ncb1142 }}
-*{{cite journal  | author=Kim SH, Han S, You YH, ''et al.'' |title=The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro. |journal=EMBO Rep. |volume=4 |issue= 7 |pages= 685-91 |year= 2004 |pmid= 12835755 |doi= 10.1038/sj.embor.embor872 }}
+* {{cite journal | vauthors = Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T | title = POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex | journal = Genes & Development | volume = 18 | issue = 14 | pages = 1649–54 | date = Jul 2004 | pmid = 15231715 | pmc = 478187 | doi = 10.1101/gad.1215404 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+* {{cite journal | vauthors = Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J | title = TIN2 mediates functions of TRF2 at human telomeres | journal = The Journal of Biological Chemistry | volume = 279 | issue = 42 | pages = 43799–804 | date = Oct 2004 | pmid = 15292264 | doi = 10.1074/jbc.M408650200 }}
-*{{cite journal  | author=Loayza D, Parsons H, Donigian J, ''et al.'' |title=DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 13241-8 |year= 2004 |pmid= 14715659 |doi= 10.1074/jbc.M312309200 }}
+* {{cite journal | vauthors = Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, Chait BT, de Lange T | title = TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres | journal = The Journal of Biological Chemistry | volume = 279 | issue = 45 | pages = 47264–71 | date = Nov 2004 | pmid = 15316005 | doi = 10.1074/jbc.M409047200 }}
-*{{cite journal  | author=Ye JZ, de Lange T |title=TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. |journal=Nat. Genet. |volume=36 |issue= 6 |pages= 618-23 |year= 2004 |pmid= 15133513 |doi= 10.1038/ng1360 }}
+* {{cite journal | vauthors = Liu D, O'Connor MS, Qin J, Songyang Z | title = Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins | journal = The Journal of Biological Chemistry | volume = 279 | issue = 49 | pages = 51338–42 | date = Dec 2004 | pmid = 15383534 | doi = 10.1074/jbc.M409293200 }}
-*{{cite journal  | author=Liu D, Safari A, O'Connor MS, ''et al.'' |title=PTOP interacts with POT1 and regulates its localization to telomeres. |journal=Nat. Cell Biol. |volume=6 |issue= 7 |pages= 673-80 |year= 2004 |pmid= 15181449 |doi= 10.1038/ncb1142 }}
+* {{cite journal | vauthors = Oh BK, Kim YJ, Park C, Park YN | title = Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis | journal = The American Journal of Pathology | volume = 166 | issue = 1 | pages = 73–80 | date = Jan 2005 | pmid = 15632001 | pmc = 1602303 | doi = 10.1016/S0002-9440(10)62233-X }}
-*{{cite journal  | author=Ye JZ, Hockemeyer D, Krutchinsky AN, ''et al.'' |title=POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. |journal=Genes Dev. |volume=18 |issue= 14 |pages= 1649-54 |year= 2004 |pmid= 15231715 |doi= 10.1101/gad.1215404 }}
+* {{cite journal | vauthors = Kaminker P, Plachot C, Kim SH, Chung P, Crippen D, Petersen OW, Bissell MJ, Campisi J, Lelièvre SA | title = Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2 | journal = Journal of Cell Science | volume = 118 | issue = Pt 6 | pages = 1321–30 | date = Mar 2005 | pmid = 15741234 | pmc = 2933191 | doi = 10.1242/jcs.01709 }}
-*{{cite journal  | author=Kim SH, Beausejour C, Davalos AR, ''et al.'' |title=TIN2 mediates functions of TRF2 at human telomeres. |journal=J. Biol. Chem. |volume=279 |issue= 42 |pages= 43799-804 |year= 2004 |pmid= 15292264 |doi= 10.1074/jbc.M408650200 }}
-*{{cite journal  | author=Ye JZ, Donigian JR, van Overbeek M, ''et al.'' |title=TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47264-71 |year= 2004 |pmid= 15316005 |doi= 10.1074/jbc.M409047200 }}
-*{{cite journal  | author=Liu D, O'Connor MS, Qin J, Songyang Z |title=Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 51338-42 |year= 2005 |pmid= 15383534 |doi= 10.1074/jbc.M409293200 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Oh BK, Kim YJ, Park C, Park YN |title=Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis. |journal=Am. J. Pathol. |volume=166 |issue= 1 |pages= 73-80 |year= 2005 |pmid= 15632001 |doi=  }}
-*{{cite journal  | author=Kaminker P, Plachot C, Kim SH, ''et al.'' |title=Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. |journal=J. Cell. Sci. |volume=118 |issue= Pt 6 |pages= 1321-30 |year= 2005 |pmid= 15741234 |doi= 10.1242/jcs.01709 }}
-}}
 {{refend}}
-{{protein-stub}}
+== External links ==
-{{WikiDoc Sources}}
+* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=dkc  GeneReviews/NCBI/NIH/UW entry on Dyskeratosis Congenita]
+{{Chromosome genetics}}
+[[Category:Telomeres]]
+[[Category:Telomere-related genes]]
+[[Category:Telomere-related proteins]]
+{{gene-14-stub}}

TINF2: Difference between revisions

Latest revision as of 06:26, 10 January 2019

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