Syndrome of inappropriate antidiuretic hormone laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]

Overview

Laboratory findings which are helpful in diagnosing SIADH include, serum electrolytes, especiallysodium, BUN, creatinine, glucose levels, and osmolality. Laboratory findings in patients withsyndrome of inappropriate antidiuretic hormone may show hyponatremia (sodium <135 mEq/L) and low serum osmolality (<280 mOsm/kg). Patients with syndrome of inappropriate antidiuretic hormone show elevated urinary sodium level (>20 mmol/L) and urine osmolality (generally >100 mOsm/L). Patients with SIADH also have low BUN, normal creatinine, hypouricemia and hypoalbuminemia.

Laboratory Findings

Lab findings consistent with the diagnosis of SIADH are;

• Hyoponatremia(<135 meq/l)
• Hypoosmolality(<280mosm/kg)
• Low BUN levels
• Hypoalbuminemia
• Hypouricemia
• NormalCreatinine
• Normal thyroid hormones
• Normalcortisol
• Increased GFR
• Increased plasma ADH levels

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