Sjögren's syndrome medical therapy: Difference between revisions

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Revision as of 18:56, 4 April 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Dry eye, dry mouth, and other sicca symptoms:
- Preferred regimen (1): Pilocarpine 5 mg PO q8h
- Preferred regimen (2): Cevimeline 30 mg PO q8h
- Preferred regimen (2): artificial tears
Organ-based disease and constitutional symptoms:
- Preferred regimen (1): Hydroxychloroquine 200 mg PO q24h
- Preferred regimen (2): Methotrexate 0.2 mg/kg weekly
- Preferred regimen (2): Leflunomide 20 mg/day
- Preferred regimen (3): Azathioprine 3 to 5 mg/kg once daily
- Preferred regimen (4): Sulfasalazine 30 mg PO q8h
- Preferred regimen (5): Cyclosporine 5 mg/kg/day
- Preferred regimen (6): Cyclophosphamide 50-100 mg/m²/day
- Preferred regimen (7): Rituximab 375 mg/m2 once weekly for 4 doses

@@ Line 8: / Line 8: @@
 **Preferred regimen (1): Pilocarpine  5 mg PO q8h
 **Preferred regimen (2): Cevimeline 30 mg PO q8h
+**Preferred regimen (2): artificial tears
 *Organ-based disease and constitutional symptoms:
-**Preferred regimen (1): Hydroxychloroquine 5 mg PO q8h
+**Preferred regimen (1): Hydroxychloroquine 200 mg PO q24h
-**Preferred regimen (2): Methotrexate 30 mg PO q8h
+**Preferred regimen (2): Methotrexate 0.2 mg/kg weekly
-**Preferred regimen (2): Leflunomide 30 mg PO q8h
+**Preferred regimen (2): Leflunomide 20 mg/day
-**Preferred regimen (2): Azathioprine  30 mg PO q8h
+**Preferred regimen (3): Azathioprine  3 to 5 mg/kg once daily
-**Preferred regimen (2): Sulfasalazine  30 mg PO q8h
+**Preferred regimen (4): Sulfasalazine  30 mg PO q8h
-**Preferred regimen (2): Cyclosporine  30 mg PO q8h
+**Preferred regimen (5): Cyclosporine  5 mg/kg/day
-**Preferred regimen (2): Cyclophosphamide  30 mg PO q8h
+**Preferred regimen (6): Cyclophosphamide 50-100 mg/m²/day
-**Preferred regimen (2): Rituximab  30 mg PO q8h
+**Preferred regimen (7): Rituximab 375 mg/m2 once weekly for 4 doses
 ==References==