Sideroblastic anemia differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.


Overview

Sideroblastic anemia must be differentiated from other causes of microcytic hypochromic anemia: iron deficiency anemia, thalassemia, anemia of chronic disease, lead poisoning, and blood loss.

Differential Diagnosis

Sideroblastic anemia must be differentiated from other causes of microcytic hypochromic anemia: iron deficiency anemia, thalassemia, anemia of chronic disease, lead poisoning, and blood loss.[1][2]

Tissue iron overload from sideroblastic anemia may act similar to hereditary hemochromatosis with liver cirrhosis, diabetes, congestive heart failure, and cardiac arrhythmias.

  • ALA Dehydratase Deficiency Porphyria
  • Acute Myeloid Leukemia (AML)
  • Congenital Erythropoietic Porphyria
  • Hereditary Coproporphyria
  • Iron Deficiency Anemia
  • Myelodysplastic Syndrome
  • Secondary Thrombocytosis

References

  1. Bottomley SS, Muller-Eberhard U (October 1988). "Pathophysiology of heme synthesis". Semin. Hematol. 25 (4): 282–302. PMID 3064310.
  2. Cattivelli K, Campagna DR, Schmitz-Abe K, Heeney MM, Yaish HM, Caruso Brown AE, Kearney S, Walkovich K, Markianos K, Fleming MD, Neufeld EJ (May 2017). "Ringed sideroblasts in β-thalassemia". Pediatr Blood Cancer. 64 (5). doi:10.1002/pbc.26324. PMC 5697724. PMID 27808451.

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