Sandbox: wdx causes

Differentiating Pancytopenia from Other Diseases

• Pancytopenia must be differentiated from a pseudo-syndromes like pseudo-thrombocytopenia, which is a laboratory artifact from platelet clumping.
• There are no other mimickers of pancytopenia, as the diagnosis can be unequivocally established by laboratory testing (complete blood count).

Category	Condition		Etiology	Mechanism			Inherited	Acquried	Clinical manifestations									Para−clinical findings									Gold standard	Associated findings
									Demography	History	Symptoms			Signs
																		Lab Findings								Imaging
											Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other	CBC			PBS	Bone marrow exam	PT	PTT	UA
				Increased megakaryocyte proliferation	Accelerated platelet release	Reduced platelet turnover												Plt	HB	WBC
Autonomous thrombocytosis	Hematologic malignancies	Essential thrombocythemia
		Polycythemia vera
		Primary myelofibrosis
		Chronic myeloid leukemia
		Myelodysplastic syndromes	Unknown Mutation	+	-	-	-/+	+	Elderly	Exposure to Chemotherapy Radiation therapy Tobacco smoke	+	Petechiae, purpura, diffuse erythematous rash	+	Nl	+	+	Shortness of breath, fatigue	↓	↓	↓	Ovalomacrocytosis Basophilic stippling Howell-Jolly body Dysplastic neutrophils	Impaired myeloid maturation Dyserythropoiesis Dysgranulopoiesis Dysmegakaryocytopoiesis Hypercellular bone marrow Fibrosis	Nl	Nl	Nl	NA	Bone marrow examination + clinical manifestation	Might transformed to acute leukemia
		Acute myeloid leukemia
	Familial thrombocytosis
Category	Condition		Etiology	Decreased platelet production	Platelet destruction in blood	Platelet destruction in spleen	Inherited	Acquried	Demography	History	Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other signs	Plt	HB	WBC	PBS	Bone marrow exam	PT	PTT	UA	Imaging	Gold standard	Associated findings
Reactive thrombocytosis	Anemia/ blood loss	Iron deficiency Blood loss Hemolysis
	Infection	Chronic infections
		Tuberculosis
		Acute bacterial and viral infections
	Inflammation	Vasculitides
		Acute pancreatitis
		Malignancy
	Tissue damage	Thermal burns
		Trauma
		Myocardial infarction
	Medication	Myelosuppressive agents
		Vincristine
		Epinephrine, glucocorticoids
		Interleukin-1B
		All-trans retinoic acid
		Thrombopoietin
	Other	Post-splenectomy or functional asplenia
		Allergic reactions
		Exercise
Category	Condition		Etiology	Decreased platelet production	Platelet destruction in blood	Platelet destruction in spleen	Inherited	Acquried	Demography	History	Fever	Rash	Bleeding	BP	Splenomegaly	Jaundice	Other signs	Plt	HB	WBC	PBS	Bone marrow exam	PT	PTT	UA	Imaging	Gold standard	Associated findings