Sandbox: wdx causes: Difference between revisions
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! rowspan="7" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hematologic | ! rowspan="7" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hematologic | ||
! align="center" style="background:#DCDCDC;" |Hereditary neutrophilia | ! align="center" style="background:#DCDCDC;" |[[Granulocytosis|Hereditary neutrophilia]] | ||
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! align="center" style="background:#DCDCDC;" |Myeloproliferative neoplasms | ! align="center" style="background:#DCDCDC;" |[[Myeloproliferative neoplasm|Myeloproliferative neoplasms]] | ||
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! align="center" style="background:#DCDCDC;" |Polycythemia | ! align="center" style="background:#DCDCDC;" |[[Polycythemia vera]] | ||
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! align="center" style="background:#DCDCDC;" |Microangiopathic hemolytic anemia (MAHA) | ! align="center" style="background:#DCDCDC;" |[[Microangiopathic hemolytic anemia]] (MAHA) | ||
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! align="center" style="background:#DCDCDC;" | | ! align="center" style="background:#DCDCDC;" |Immune thrombocytopenia | ||
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | ||
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! align="center" style="background:#DCDCDC;" |Leukocyte adhesion deficiency | ! align="center" style="background:#DCDCDC;" |[[Leukocyte adhesion deficiency]] | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
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! align="center" style="background:#DCDCDC;" |Rheumatoid arthritis | ! align="center" style="background:#DCDCDC;" |[[Rheumatoid arthritis]] | ||
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! align="center" style="background:#DCDCDC;" |Juvenile onset rheumatoid arthritis | ! align="center" style="background:#DCDCDC;" |[[Juvenile rheumatoid arthritis|Juvenile onset rheumatoid arthritis]] | ||
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! align="center" style="background:#DCDCDC;" |Adult Still's disease | ! align="center" style="background:#DCDCDC;" |[[Still's disease|Adult Still's disease]] | ||
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! align="center" style="background:#DCDCDC;" |Kawasaki disease | ! align="center" style="background:#DCDCDC;" |[[Kawasaki disease]] | ||
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! align="center" style="background:#DCDCDC;" |IBD | ! align="center" style="background:#DCDCDC;" |[[Inflammatory bowel disease|IBD]] | ||
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! align="center" style="background:#DCDCDC;" |Sarcoidosis | ! align="center" style="background:#DCDCDC;" |[[Sarcoidosis]] | ||
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! align="center" style="background:#DCDCDC;" |Chronic hepatitis | ! align="center" style="background:#DCDCDC;" |[[Hepatitis|Chronic hepatitis]] | ||
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! align="center" style="background:#DCDCDC;" |Sweet syndrome | ! align="center" style="background:#DCDCDC;" |[[Sweet's syndrome|Sweet syndrome]] | ||
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! align="center" style="background:#DCDCDC;" |Acute | ! align="center" style="background:#DCDCDC;" |[[Gout|Acute gout]] | ||
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | ||
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! align="center" style="background:#DCDCDC;" |Acute bacterial | ! align="center" style="background:#DCDCDC;" |[[Infection|Acute bacterial]] | ||
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! align="center" style="background:#DCDCDC;" |Chronic | ! align="center" style="background:#DCDCDC;" |[[Infection|Chronic infection]] | ||
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! align="center" style="background:#DCDCDC;" |Viral infection | ! align="center" style="background:#DCDCDC;" |[[Infection|Viral infection]] | ||
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! align="center" style="background:#DCDCDC;" |Granulomatous infections | ! align="center" style="background:#DCDCDC;" |[[Granuloma|Granulomatous]] infections | ||
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! align="center" style="background:#DCDCDC;" |Bronchiectasis | ! align="center" style="background:#DCDCDC;" |[[Bronchiectasis]] | ||
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! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Metabolic | ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Metabolic | ||
! align="center" style="background:#DCDCDC;" |Diabetic coma | ! align="center" style="background:#DCDCDC;" |[[Diabetic coma]] | ||
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! align="center" style="background:#DCDCDC;" |Acidosis | ! align="center" style="background:#DCDCDC;" |[[Acidosis]] | ||
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! align="center" style="background:#DCDCDC;" |Thyroid | ! align="center" style="background:#DCDCDC;" |[[Thyroid storm]] | ||
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! align="center" style="background:#DCDCDC;" |Hypercortisolism | ! align="center" style="background:#DCDCDC;" |[[Cushing's syndrome|Hypercortisolism]] | ||
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! align="center" style="background:#DCDCDC;" |Seizures | ! align="center" style="background:#DCDCDC;" |[[Seizure|Seizures]] | ||
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! rowspan=" | ! rowspan="7" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Medication | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | ||
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | ||
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! align="center" style="background:#DCDCDC;" |Steriod | ! align="center" style="background:#DCDCDC;" |[[Steroid|Steriod]] | ||
| align="center" style="background:#F5F5F5;" + |Release of granulocytes from the bone marrow | | align="center" style="background:#F5F5F5;" + | | ||
* Release of granulocytes from the bone marrow | |||
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! align="center" style="background:#DCDCDC;" |Lithium | ! align="center" style="background:#DCDCDC;" |[[Lithium]] | ||
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! align="center" style="background:#DCDCDC;" | | ! align="center" style="background:#DCDCDC;" |[[Cytokine|Cytokines]] | ||
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! align="center" style="background:#DCDCDC;" | | ! align="center" style="background:#DCDCDC;" |[[Catecholamine|Catecholamines]] ([[epinephrine]]) | ||
| align="center" style="background:#F5F5F5;" + | | | align="center" style="background:#F5F5F5;" + | | ||
* Stimulation of bone marrow myelopoiesis | |||
* Egress into the circulation | |||
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! align="center" style="background:#DCDCDC;" |ATRA | ! align="center" style="background:#DCDCDC;" |[[Tretinoin|ATRA]] | ||
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings | ||
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! align="center" style="background:#DCDCDC;" |Allergy | ! align="center" style="background:#DCDCDC;" |[[Allergy]] | ||
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! align="center" style="background:#DCDCDC;" |Post splenectomy | ! align="center" style="background:#DCDCDC;" |Post [[splenectomy]] | ||
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! align="center" style="background:#DCDCDC;" |Down syndrome | ! align="center" style="background:#DCDCDC;" |[[Down syndrome]] | ||
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! align="center" style="background:#DCDCDC;" |Cigarette smoking | ! align="center" style="background:#DCDCDC;" |[[Smoking|Cigarette smoking]] | ||
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! align="center" style="background:#DCDCDC;" |Stress/exercise | ! align="center" style="background:#DCDCDC;" |[[Stress (medicine)|Stress]]/[[Physical exercise|exercise]] | ||
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! align="center" style="background:#DCDCDC;" |Infancy | ! align="center" style="background:#DCDCDC;" |[[Infant|Infancy]] | ||
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! align="center" style="background:#DCDCDC;" |Pregnancy | ! align="center" style="background:#DCDCDC;" |[[Pregnancy]] | ||
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! align="center" style="background:#DCDCDC;" |Platelet clumping | ! align="center" style="background:#DCDCDC;" |[[Platelet]] clumping | ||
| align="center" style="background:#F5F5F5;" + |Spurious | | align="center" style="background:#F5F5F5;" + |Spurious | ||
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! align="center" style="background:#DCDCDC;" |Mixed cryoglobulinemia | ! align="center" style="background:#DCDCDC;" |[[Cryoglobulinemia|Mixed cryoglobulinemia]] | ||
| align="center" style="background:#F5F5F5;" + |Spurious | | align="center" style="background:#F5F5F5;" + |Spurious | ||
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Revision as of 19:29, 13 September 2018
Differentiating Leukocytosis from Other Diseases
- Leukocytosis is defined as an elevated white blood cell (WBC) count greater than 11,000 per mm3 (11.0 × 109 per L).
- The most common type of leukocytosis is neutrophilia.
- Neutrophilia can be defined as an increase in the absolute number of mature neutrophils to greater than 7,000 per mm3 [7.0 × 109 per L].
| Category | Condition | Etiology | Mechanism | Congenital | Acquried | Clinical manifestations | Para−clinical findings | Gold standard | Associated findings | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Demography | History | Symptoms | Signs | ||||||||||||||||||||||||||
| Lab Findings | |||||||||||||||||||||||||||||
| Physiologic | Increased bone marrow production | Demargination of peripheral blood neutrophils | Appearance | Fever | Abdominal pain | BP | Asplenia | Hepatosplenomegaly | Lymphadenopathy | Joint redness | Other | CBC | PBS | Bone marrow exam | ESR/CRP | BUN/Cr | LFT | ||||||||||||
| Autonomous | Reactive | WBC | HB | Plt | |||||||||||||||||||||||||
| Hematologic | Hereditary neutrophilia | ||||||||||||||||||||||||||||
| Hereditary chronic neutrophilia | |||||||||||||||||||||||||||||
| Myeloproliferative neoplasms | |||||||||||||||||||||||||||||
| Polycythemia vera | |||||||||||||||||||||||||||||
| Microangiopathic hemolytic anemia (MAHA) | |||||||||||||||||||||||||||||
| Leukoerythroblastosis | |||||||||||||||||||||||||||||
| Immune thrombocytopenia | |||||||||||||||||||||||||||||
| Immunology/
Rheumatology |
Condition | Etiology | Physiologic | Autonomous increased bone marrow production | Reactive increased bone marrow production | Demargination of peripheral blood neutrophils | Congenital | Acquried | Demography | History | Appearance | Fever | Abdominal pain | BP | Asplenia | Hepatosplenomegaly | Lymphadenopathy | Joint redness | Other signs | WBC | HB | Plt | PBS | Bone marrow exam | ESR/CRP | BUN/Cr | LFT | Gold standard | Associated findings |
| Leukocyte adhesion deficiency | |||||||||||||||||||||||||||||
| Cryopyrin-associated periodic syndromes | |||||||||||||||||||||||||||||
| Rheumatoid arthritis | |||||||||||||||||||||||||||||
| Juvenile onset rheumatoid arthritis | |||||||||||||||||||||||||||||
| Adult Still's disease | |||||||||||||||||||||||||||||
| Kawasaki disease | |||||||||||||||||||||||||||||
| IBD | |||||||||||||||||||||||||||||
| Sarcoidosis | |||||||||||||||||||||||||||||
| Chronic hepatitis | |||||||||||||||||||||||||||||
| Sweet syndrome | |||||||||||||||||||||||||||||
| Acute gout | |||||||||||||||||||||||||||||
| Infection | Condition | Etiology | Physiologic | Autonomous increased bone marrow production | Reactive increased bone marrow production | Demargination of peripheral blood neutrophils | Congenital | Acquried | Demography | History | Appearance | Fever | Abdominal pain | BP | Asplenia | Hepatosplenomegaly | Lymphadenopathy | Joint redness | Other signs | WBC | HB | Plt | PBS | Bone marrow exam | ESR/CRP | BUN/Cr | LFT | Gold standard | Associated findings |
| Acute bacterial | toxic granulations, Döhle bodies, and cytoplasmic vacuoles in neutrophils | ||||||||||||||||||||||||||||
| Chronic infection | |||||||||||||||||||||||||||||
| Viral infection | |||||||||||||||||||||||||||||
| Granulomatous infections | |||||||||||||||||||||||||||||
| Bronchiectasis | |||||||||||||||||||||||||||||
| Metabolic | Diabetic coma | ||||||||||||||||||||||||||||
| Acidosis | |||||||||||||||||||||||||||||
| Thyroid storm | |||||||||||||||||||||||||||||
| Hypercortisolism | |||||||||||||||||||||||||||||
| Seizures | |||||||||||||||||||||||||||||
| Medication | Condition | Etiology | Physiologic | Autonomous increased bone marrow production | Reactive increased bone marrow production | Demargination of peripheral blood neutrophils | Congenital | Acquried | Demography | History | Appearance | Fever | Abdominal pain | BP | Asplenia | Hepatosplenomegaly | Lymphadenopathy | Joint redness | Other signs | WBC | HB | Plt | PBS | Bone marrow exam | ESR/CRP | BUN/Cr | LFT | Gold standard | Associated findings |
| Steriod |
|
||||||||||||||||||||||||||||
| Myeloid growth factors | |||||||||||||||||||||||||||||
| Lithium | |||||||||||||||||||||||||||||
| Cytokines | |||||||||||||||||||||||||||||
| Catecholamines (epinephrine) |
|
||||||||||||||||||||||||||||
| ATRA | |||||||||||||||||||||||||||||
| Other | Condition | Etiology | Physiologic | Autonomous increased bone marrow production | Reactive increased bone marrow production | Demargination of peripheral blood neutrophils | Congenital | Acquried | Demography | History | Appearance | Fever | Abdominal pain | BP | Asplenia | Hepatosplenomegaly | Lymphadenopathy | Joint redness | Other signs | WBC | HB | Plt | PBS | Bone marrow exam | ESR/CRP | BUN/Cr | LFT | Gold standard | Associated findings |
| Allergy | |||||||||||||||||||||||||||||
| Post splenectomy | |||||||||||||||||||||||||||||
| Down syndrome | |||||||||||||||||||||||||||||
| Cigarette smoking | |||||||||||||||||||||||||||||
| Stress/exercise | |||||||||||||||||||||||||||||
| Infancy | |||||||||||||||||||||||||||||
| Pregnancy | |||||||||||||||||||||||||||||
| Platelet clumping | Spurious | ||||||||||||||||||||||||||||
| Mixed cryoglobulinemia | Spurious | ||||||||||||||||||||||||||||
| Category | Condition | Etiology | Physiologic | Autonomous increased bone marrow production | Reactive increased bone marrow production | Demargination of peripheral blood neutrophils | Congenital | Acquried | Demography | History | Appearance | Fever | Abdominal pain | BP | Asplenia | Hepatosplenomegaly | Lymphadenopathy | Joint redness | Other signs | WBC | HB | Plt | PBS | Bone marrow exam | ESR/CRP | BUN/Cr | LFT | Gold standard | Associated findings |