Sandbox: wdx causes: Difference between revisions

Latest revision as of 21:38, 17 September 2018

Differentiating Leukocytosis from Other Diseases

Category	Condition	Etiology	Mechanism				Congenital	Acquried	Clinical manifestations											Para−clinical findings								Gold standard	Associated findings
									Demography	History	Symptoms			Signs						Para−clinical findings
											Symptoms			Signs						Lab Findings
			Physiologic	Increased bone marrow production		Demargination of peripheral blood neutrophils					Appearance	Fever	Abdominal pain	BP	Asplenia	Hepatosplenomegaly	Lymphadenopathy	Joint redness	Other	CBC			PBS	Bone marrow exam	ESR/CRP	BUN/Cr	LFT
			Physiologic	Autonomous	Reactive	Demargination of peripheral blood neutrophils					Appearance	Fever	Abdominal pain	BP	Asplenia	Hepatosplenomegaly	Lymphadenopathy	Joint redness	Other	WBC	HB	Plt	PBS	Bone marrow exam	ESR/CRP	BUN/Cr	LFT
Hematologic	Hereditary neutrophilia	Unknown Germline mutation in CSF3R	-	+	--	-	+	-	Rare autosomal dominant genetic disorder	Positive family history	Normal	-	-	Nl	-	+	-	-	-	↑	Nl	Nl	Normal granulocytes Histiocytes of Gaucher type	Nl	Nl	Nl	Nl	Genetic study	High leukocyte alkaline phosphatase Progress to leukemia
	Hereditary chronic neutrophilia
	Myeloproliferative neoplasms
	Polycythemia vera
	Microangiopathic hemolytic anemia (MAHA)
	Leukoerythroblastosis
	Immune thrombocytopenia
Immunology/ Rheumatology	Condition	Etiology	Physiologic	Autonomous increased bone marrow production	Reactive increased bone marrow production	Demargination of peripheral blood neutrophils	Congenital	Acquried	Demography	History	Appearance	Fever	Abdominal pain	BP	Asplenia	Hepatosplenomegaly	Lymphadenopathy	Joint redness	Other signs	WBC	HB	Plt	PBS	Bone marrow exam	ESR/CRP	BUN/Cr	LFT	Gold standard	Associated findings
	Leukocyte adhesion deficiency
	Cryopyrin-associated periodic syndromes
	Rheumatoid arthritis
	Juvenile onset rheumatoid arthritis
	Adult Still's disease
	Kawasaki disease
	IBD
	Sarcoidosis
	Chronic hepatitis
	Sweet syndrome
	Acute gout
Infection	Condition	Etiology	Physiologic	Autonomous increased bone marrow production	Reactive increased bone marrow production	Demargination of peripheral blood neutrophils	Congenital	Acquried	Demography	History	Appearance	Fever	Abdominal pain	BP	Asplenia	Hepatosplenomegaly	Lymphadenopathy	Joint redness	Other signs	WBC	HB	Plt	PBS	Bone marrow exam	ESR/CRP	BUN/Cr	LFT	Gold standard	Associated findings
	Acute bacterial																						toxic granulations, Döhle bodies, and cytoplasmic vacuoles in neutrophils
	Chronic infection
	Viral infection
	Granulomatous infections
	Bronchiectasis
Metabolic	Diabetic coma
	Acidosis
	Thyroid storm
	Hypercortisolism
	Seizures
Medication	Condition	Etiology	Physiologic	Autonomous increased bone marrow production	Reactive increased bone marrow production	Demargination of peripheral blood neutrophils	Congenital	Acquried	Demography	History	Appearance	Fever	Abdominal pain	BP	Asplenia	Hepatosplenomegaly	Lymphadenopathy	Joint redness	Other signs	WBC	HB	Plt	PBS	Bone marrow exam	ESR/CRP	BUN/Cr	LFT	Gold standard	Associated findings
	Steriod	Release of granulocytes from the bone marrow
	Myeloid growth factors
	Lithium
	Cytokines
	Catecholamines (epinephrine)	Stimulation of bone marrow myelopoiesis Egress into the circulation
	ATRA
Other	Condition	Etiology	Physiologic	Autonomous increased bone marrow production	Reactive increased bone marrow production	Demargination of peripheral blood neutrophils	Congenital	Acquried	Demography	History	Appearance	Fever	Abdominal pain	BP	Asplenia	Hepatosplenomegaly	Lymphadenopathy	Joint redness	Other signs	WBC	HB	Plt	PBS	Bone marrow exam	ESR/CRP	BUN/Cr	LFT	Gold standard	Associated findings
	Allergy
	Post splenectomy
	Down syndrome
	Cigarette smoking
	Stress/exercise
	Infancy
	Pregnancy
	Platelet clumping	Spurious
	Mixed cryoglobulinemia	Spurious
Category	Condition	Etiology	Physiologic	Autonomous increased bone marrow production	Reactive increased bone marrow production	Demargination of peripheral blood neutrophils	Congenital	Acquried	Demography	History	Appearance	Fever	Abdominal pain	BP	Asplenia	Hepatosplenomegaly	Lymphadenopathy	Joint redness	Other signs	WBC	HB	Plt	PBS	Bone marrow exam	ESR/CRP	BUN/Cr	LFT	Gold standard	Associated findings

@@ Line 1: / Line 1: @@
-==Differentiating Pancytopenia from Other Diseases==
+==Differentiating Leukocytosis from Other Diseases==
-* There are no other mimickers of pancytopenia, as the diagnosis can be unequivocally established by laboratory testing ([[complete blood count]]).
 {|
 ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
 ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
 ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
-! colspan="3" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism
+! colspan="4" rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism
 ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
 ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
-! colspan="9" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations
+! colspan="11" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations
 ! colspan="8" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para−clinical findings
 ! colspan="1" rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
@@ Line 17: / Line 15: @@
 ! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
 ! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms
-| colspan="4" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
+| colspan="6" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
 |-
 ! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
 |-
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic
+! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Increased bone marrow production
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils
 ! colspan="1" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
 ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
-! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain
 ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
-! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia
-! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness
 ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
 ! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |CBC
 ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
 ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
-! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP
-! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
-! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
+! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
 |-
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
-sequestration/
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
-redistribution
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
 |-
-! rowspan="10" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hematologic disorders
+! rowspan="7" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hematologic
-! align="center" style="background:#DCDCDC;" |[[Myelodysplastic syndrome (patient information)|Myelodysplastic syndrome]]
+! align="center" style="background:#DCDCDC;" |[[Granulocytosis|Hereditary neutrophilia]]
-| align="left" style="background:#F5F5F5;" |
+| align="center" style="background:#F5F5F5;" + |
-* [[Bone marrow]] infiltration
+* Unknown
-* Ineffective [[hematopoiesis]]
+* Germline mutation in [[CSF3R]]
-| align="center" style="background:#F5F5F5;" | +
+| align="center" style="background:#F5F5F5;" + | -
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" | ±
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" |Elderly
-| align="center" style="background:#F5F5F5;" |Exposure to
-* [[Chemotherapy]]
-* [[Radiation therapy]]
-* [[Tobacco smoking|Tobacco smoke]]
-| align="center" style="background:#F5F5F5;" |
-* [[Petechia|Petechiae]]
-* [[Purpura]]
-* Diffuse erythematous rash
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" |
-* [[Shortness of breath]]
-* [[Fatigue]]
-* [[Pallor]]
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |
-*Ovalomacrocytosis
-*Basophilic stippling
-*[[Howell-Jolly body]]
-*Dysplastic [[Neutrophil|neutrophils]]
-| align="center" style="background:#F5F5F5;" |
-*Impaired [[myeloid]] maturation
-*[[Congenital dyserythropoietic anemia|Dyserythropoiesis]]
-*Dysgranulopoiesis
-*Dysmegakaryocytopoiesis
-*Hypercellular [[bone marrow]]
-*[[Fibrosis]]
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |[[Bone marrow examination]] + clinical manifestation
-| align="center" style="background:#F5F5F5;" |
-*Might transformed to [[acute leukemia]]
-|-
-! align="left" style="background:#DCDCDC;" |Malignancies such as:
-* [[Acute leukemia]]
-* [[Chronic leukemia]]
-* [[Multiple myeloma]]
-* [[Metastasis|Metastatic cancer]]
-| align="left" style="background:#F5F5F5;" + |
-* [[Bone marrow]] infiltration
-* Ineffective [[hematopoiesis]]
-* Immune mediated
 | align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + | --
+| align="center" style="background:#F5F5F5;" + | -
 | align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + | -
-| align="center" style="background:#F5F5F5;" + |±
+| align="center" style="background:#F5F5F5;" + |Rare [[Dominance relationship|autosomal dominant]] genetic disorder
-| align="center" style="background:#F5F5F5;" + |±
-| align="center" style="background:#F5F5F5;" + |Any, more in adults
 | align="center" style="background:#F5F5F5;" + |
-*Exposure to chemicals
+* Positive family history
-*[[Radiation therapy|Radiation]]
+| align="center" style="background:#F5F5F5;" + |Normal
-*Pre-existent blood disorders
+| align="center" style="background:#F5F5F5;" + |-
+| align="center" style="background:#F5F5F5;" + |-
+| align="center" style="background:#F5F5F5;" + |Nl
+| align="center" style="background:#F5F5F5;" + |-
+| align="center" style="background:#F5F5F5;" + |+
+| align="center" style="background:#F5F5F5;" + |-
+| align="center" style="background:#F5F5F5;" + |-
+| align="center" style="background:#F5F5F5;" + |-
+| align="center" style="background:#F5F5F5;" + |↑
+| align="center" style="background:#F5F5F5;" + |Nl
+| align="center" style="background:#F5F5F5;" + |Nl
 | align="center" style="background:#F5F5F5;" + |
-* [[Petechia|Petechiae]]
+* Normal [[Granulocyte|granulocytes]]
-| align="center" style="background:#F5F5F5;" + | +
+* [[Histiocyte|Histiocytes]] of Gaucher type
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |Nl
+| align="center" style="background:#F5F5F5;" + |Nl
+| align="center" style="background:#F5F5F5;" + |Nl
 | align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |[[Genetics|Genetic]] study
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
+* High [[leukocyte alkaline phosphatase]]
+* Progress to [[leukemia]]
+|-
+! align="center" style="background:#DCDCDC;" |Hereditary chronic neutrophilia
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+|-
+! align="center" style="background:#DCDCDC;" |[[Myeloproliferative neoplasm|Myeloproliferative neoplasms]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+|-
+! align="center" style="background:#DCDCDC;" |[[Polycythemia vera]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+|-
+! align="center" style="background:#DCDCDC;" |[[Microangiopathic hemolytic anemia]] (MAHA)
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-*[[Muscle weakness|Weakness]]
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Blast cells
-*
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + |↑
 | align="center" style="background:#F5F5F5;" + |
-*[[Hemoglobinuria]]
-| align="center" style="background:#F5F5F5;" + |Bone marrow examination
 | align="center" style="background:#F5F5F5;" + |
-*[[Tumor lysis syndrome]]
-*[[Infection]]
-*[[CNS]] involvement
-*[[Disseminated intravascular coagulation|DIC]]
 |-
-! align="center" style="background:#DCDCDC;" |[[Myelofibrosis]]
+! align="center" style="background:#DCDCDC;" |Leukoerythroblastosis
-| align="left" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
-* Bone marrow infiltration
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |Average 60 years old
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-*Exposure to chemicals
-*[[Radiation therapy|Radiation]]
-*Pre-existent blood disorders
 | align="center" style="background:#F5F5F5;" + |
-* [[Pallor]]
-* Major weight loss
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
 | align="center" style="background:#F5F5F5;" + |
-*[[Muscle weakness|Weakness]]
-*[[Fatigue]]
-* [[Dyspnea|Shortness of breath]]
-* [[Headache]]
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-* [[Pancytopenia]]
-*Hypercellular [[bone marrow]]
-*[[Fibrosis]]
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + |↑
 | align="center" style="background:#F5F5F5;" + |
-*[[Hemoglobinuria]]
-| align="center" style="background:#F5F5F5;" + |Bone marrow examination
 | align="center" style="background:#F5F5F5;" + |
-* [[Cardiac arrhythmia|Arrhythmia]]
-* [[Infection]]
-* [[Seizure]]
-* May progress to malignancy
 |-
-! align="center" style="background:#DCDCDC;" |[[Fanconi anemia]]
+! align="center" style="background:#DCDCDC;" |Immune thrombocytopenia
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-* Genetic defect
-* Bone marrow failure
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |Rare  [[autosomal recessive]] genetic disorder, higher in Ashkenazi Jews and Afrikaners in South Africa
 | align="center" style="background:#F5F5F5;" + |
-* Family history of [[Fanconi anemia]]
 | align="center" style="background:#F5F5F5;" + |
-* Short stature
-* Petechiae and bruises
-* Pallor
-* Skin discoloration
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
 | align="center" style="background:#F5F5F5;" + |
-* Skeletal defects
-* Deafness
-* VSD
-* Kidney abnormalities
-*
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-* [[Pancytopenia]]
-*Hypercellular [[bone marrow]]
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Genetic studies
 | align="center" style="background:#F5F5F5;" + |
-* Progress to [[Acute myeloid leukemia|acute myelogenous leukemia]]
-* [[Neoplasm|Solid tumors]]
-* [[Developmental abnormality|Developmental abnormalities]]
 |-
+! rowspan="12" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Immunology/
+Rheumatology
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production
-sequestration/
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils
-redistribution
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
@@ Line 247: / Line 276: @@
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
 |-
-! align="center" style="background:#DCDCDC;" |[[Aplastic anemia]]
+! align="center" style="background:#DCDCDC;" |[[Leukocyte adhesion deficiency]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+|-
+! align="center" style="background:#DCDCDC;" |Cryopyrin-associated periodic syndromes
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+|-
+! align="center" style="background:#DCDCDC;" |[[Rheumatoid arthritis]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+|-
+! align="center" style="background:#DCDCDC;" |[[Juvenile rheumatoid arthritis|Juvenile onset rheumatoid arthritis]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+|-
+! align="center" style="background:#DCDCDC;" |[[Still's disease|Adult Still's disease]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+|-
+! align="center" style="background:#DCDCDC;" |[[Kawasaki disease]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+|-
+! align="center" style="background:#DCDCDC;" |[[Inflammatory bowel disease|IBD]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-*Unknown
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |±
-| align="center" style="background:#F5F5F5;" + |±
-| align="center" style="background:#F5F5F5;" + |Biphasic (the young and the elderly)
 | align="center" style="background:#F5F5F5;" + |
-* Exposure to [[Radiation (medicine)|radiation]], drugs and chemicals, [[pregnancy]], [[Paroxysmal nocturnal hemoglobinuria|PNH]] and viral or [[Autoimmune disease|autoimmune]] causes
 | align="center" style="background:#F5F5F5;" + |
-* [[Pallor]]
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
 | align="center" style="background:#F5F5F5;" + |
-*[[Shortness of breath]]
-*[[Fatigue]]
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*Large [[Red blood cell|RBCs]]
-*Low [[Platelet|platelets]] and [[Granulocyte|granulocytes]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-*replacement of [[bone marrow]] by [[fat]]
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |[[Bone marrow examination]] +
-laboratory findings
 | align="center" style="background:#F5F5F5;" + |
-*[[Fanconi anemia|Fanconi Anemia]]
-*[[Dyskeratosis congenita]]
-*[[Shwachman-Diamond syndrome|Schwachman-Diamond syndrome]]
-*[[Preleukemia]]
 |-
-! align="center" style="background:#DCDCDC;" |[[Paroxysmal nocturnal hemoglobinuria]]
+! align="center" style="background:#DCDCDC;" |[[Sarcoidosis]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-*Deficiency of [[complement]] regulatory proteins
-*Mutations
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Any age
-(usually younger adults)
 | align="center" style="background:#F5F5F5;" + |
-*Sudden [[nocturnal]] [[hemoglobinuria]] with partial clearing during the day
 | align="center" style="background:#F5F5F5;" + |
-* Normal
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
 | align="center" style="background:#F5F5F5;" + |
-*[[Thrombosis]]
-*Smooth muscle [[dystonia]]
-| align="center" style="background:#F5F5F5;" + |↓/Nl
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓/Nl
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Cellular [[Bone marrow|marrow]]
-*[[Erythroid]] [[hyperplasia]]
-*[[dyserythropoiesis]]
-*Hypocellular marrow in certain stages of the disease
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
 | align="center" style="background:#F5F5F5;" + |
-*[[Hemoglobinuria]]
-| align="center" style="background:#F5F5F5;" + |[[Flow cytometry]]
 | align="center" style="background:#F5F5F5;" + |
-*[[Chronic renal failure]]
-*[[Pulmonary hypertension]]
-*[[Aplastic anemia]]
 |-
-! align="center" style="background:#DCDCDC;" |[[Disseminated intravascular coagulation]]
+! align="center" style="background:#DCDCDC;" |[[Hepatitis|Chronic hepatitis]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-* Consumption
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Any
 | align="center" style="background:#F5F5F5;" + |
-* [[Infection]]
-* [[Physical trauma|Trauma]]
-* [[Obstetrics]] complications
-* [[Cancer]]
-* [[Shock]]
 | align="center" style="background:#F5F5F5;" + |
-* Acutely ill
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
 | align="center" style="background:#F5F5F5;" + |
-*[[Shortness of breath]]
-*[[Fatigue]]
-*[[Chest pain]]
-| align="center" style="background:#F5F5F5;" + |↓/Nl
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓/Nl
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
-| align="center" style="background:#F5F5F5;" + |NA
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + |↑
 | align="center" style="background:#F5F5F5;" + |
-*[[Hemoglobinuria]]
-| align="center" style="background:#F5F5F5;" + |Lab findings
 | align="center" style="background:#F5F5F5;" + |
-* High mortality rate
 |-
-! align="center" style="background:#DCDCDC;" |Dyskeratosis congenital/telomere biology disorders
+! align="center" style="background:#DCDCDC;" |[[Sweet's syndrome|Sweet syndrome]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-* Aberrant telomere biology
-* Germline mutations
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |Rare genetic disorder
 | align="center" style="background:#F5F5F5;" + |
-* Family history
 | align="center" style="background:#F5F5F5;" + |
-* [[Isolated congenital nail dysplasia|Nail dysplasia]]
-* Abnormal skin pigmentation
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
 | align="center" style="background:#F5F5F5;" + |
-* [[Leukoplakia|Oral leukoplakia]]
-* [[Shortness of breath]]
-*[[Fatigue]]
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Clinical findings + genetic studies
 | align="center" style="background:#F5F5F5;" + |
-* Progress to [[Cancer|malignancy]]
-* [[Idiopathic pulmonary fibrosis|Pulmonary fibrosis]]
-* [[Hepato-biliary diseases|Liver disease]]
 |-
-! align="center" style="background:#DCDCDC;" |[[Shwachman-Diamond syndrome]]
+! align="center" style="background:#DCDCDC;" |[[Gout|Acute gout]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-* Germline mutations
-* Bone marrow failure
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |Rare genetic disorder
 | align="center" style="background:#F5F5F5;" + |
-* Family history
 | align="center" style="background:#F5F5F5;" + |
-* Skeletal abnormalities
-* [[Short stature]]
-* [[Metaphyseal dysostosis mental retardation conductive deafness|Metaphyseal dysostosis]]
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
 | align="center" style="background:#F5F5F5;" + |
-* [[Steatorrhea]]
-* [[Delayed milestone|Growth retardation]]
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Clinical findings + genetic studies
 | align="center" style="background:#F5F5F5;" + |
-* [[Pancreatic insufficiency|Exocrine pancreatic insufficiency]]
-* [[Delayed milestone|Growth retardation]]
-* Increased frequency of [[Infection|infections]]
 |-
-! rowspan="6" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Immunology/
+! rowspan="6" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Infection
-Rheumatology
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production
-sequestration/
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils
-redistribution
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
@@ Line 484: / Line 637: @@
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
 |-
-! align="center" style="background:#DCDCDC;" |[[SLE]]
+! align="center" style="background:#DCDCDC;" |[[Infection|Acute bacterial]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |toxic granulations, Döhle bodies, and cytoplasmic vacuoles in neutrophils
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+|-
+! align="center" style="background:#DCDCDC;" |[[Infection|Chronic infection]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+|-
+! align="center" style="background:#DCDCDC;" |[[Infection|Viral infection]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+|-
+! align="center" style="background:#DCDCDC;" |[[Granuloma|Granulomatous]] infections
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-* Immune mediated bone marrow failure
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |More in young females
 | align="center" style="background:#F5F5F5;" + |
-* Family history
 | align="center" style="background:#F5F5F5;" + |
-* [[Rash|Skin rash]]
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Nl to ↓
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
 | align="center" style="background:#F5F5F5;" + |
-* [[Weight loss]]
-* [[Oral ulcer|Mouth ulcers]]
-* [[Chest pain]]
-* [[Lymphadenopathy]]
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + |↑
 | align="center" style="background:#F5F5F5;" + |
-*[[Hemoglobinuria]]
-*[[Proteinuria]]
-| align="center" style="background:#F5F5F5;" + |Clinical findings + laboratory studies
 | align="center" style="background:#F5F5F5;" + |
-* Multi organ damage
-* Poor prognosis
 |-
-! align="center" style="background:#DCDCDC;" |[[Felty's syndrome|Felty syndrome]]
+! align="center" style="background:#DCDCDC;" |[[Bronchiectasis]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-* Immune mediated bone marrow failure
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Rare [[autoimmune disease]], more in females 50-70 years old
 | align="center" style="background:#F5F5F5;" + |
-* History of [[rheumatoid arthritis]]
 | align="center" style="background:#F5F5F5;" + |
-* [[Pallor]]
-* [[Hyperpigmentation|Skin hyperpigmentation]]
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
 | align="center" style="background:#F5F5F5;" + |
-* Painful, stiff, and swollen [[Joint|joints]]
-* [[Keratoconjunctivitis sicca]]
-* [[Weight loss]]
-* [[Fatigue]]
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Clinical findings + laboratory studies
 | align="center" style="background:#F5F5F5;" + |
-* [[Rheumatoid arthritis]]
-* [[Infection|Infections]]
 |-
-! align="center" style="background:#DCDCDC;" |[[Wiskott-Aldrich syndrome|Wiskott Aldrich syndrome]]
+! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Metabolic
+! align="center" style="background:#DCDCDC;" |[[Diabetic coma]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-* Mutation in [[GATA1|GATA-1]]
-* Immune mediated bone marrow failure
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |Rare [[Sex-linked|X-linked]] [[Recessive gene|recessive]] disease
 | align="center" style="background:#F5F5F5;" + |
-* [[Immunodeficiency]]
-* Positive family history
 | align="center" style="background:#F5F5F5;" + |
-*[[Eczema]]
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
 | align="center" style="background:#F5F5F5;" + |
-* [[Dysentery|Bloody diarrhea]]
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-*Small but low [[Platelet|platelets]]
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Genetic study
 | align="center" style="background:#F5F5F5;" + |
-*Recurrent [[Infection|infections]]
-*[[Autoimmune disease|autoimmune disorders]]
-*[[Cancer|Malignancy]]
 |-
-! align="center" style="background:#DCDCDC;" |[[GATA2]] deficiency
+! align="center" style="background:#DCDCDC;" |[[Acidosis]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-* Immune mediated bone marrow failure
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |Rare
 | align="center" style="background:#F5F5F5;" + |
-* [[Immunodeficiency]]
-* Positive family history
 | align="center" style="background:#F5F5F5;" + |
-*[[Purpura]]
-*[[Petechia|Petechiae]]
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Genetic study
 | align="center" style="background:#F5F5F5;" + |
-*Recurrent [[Infection|infections]]
-*[[Autoimmune disease|autoimmune disorders]]
-*[[Cancer|Malignancy]]
 |-
-! align="center" style="background:#DCDCDC;" |[[Hemophagocytic lymphohistiocytosis]]
+! align="center" style="background:#DCDCDC;" |[[Thyroid storm]]
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-* Immune mediated bone marrow failure
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |Rare
 | align="center" style="background:#F5F5F5;" + |
-* [[Immunodeficiency]]
-* Positive family history
 | align="center" style="background:#F5F5F5;" + |
-*[[Purpura]]
-*[[Petechia|Petechiae]]
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Genetic study
 | align="center" style="background:#F5F5F5;" + |
-*Recurrent [[Infection|infections]]
-*[[Autoimmune disease|autoimmune disorders]]
-*[[Cancer|Malignancy]]
 |-
-! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |GI disorders
+! align="center" style="background:#DCDCDC;" |[[Cushing's syndrome|Hypercortisolism]]
-! align="center" style="background:#DCDCDC;" |[[Portal hypertension]]/[[cirrhosis]]
+| align="center" style="background:#F5F5F5;" + |
-| align="left" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
-* Splenomegally
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |Any
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-*[[Cirrhosis]]
-*[[Alcoholism|Alcohol use]]
 | align="center" style="background:#F5F5F5;" + |
-*[[Purpura]]
-*[[Petechia|Petechiae]]
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Clinical manifestation
 | align="center" style="background:#F5F5F5;" + |
-*[[Portal vein thrombosis]]
-*[[Hepatorenal syndrome]]
-*Variceal hemorrhage
-*Hepatic [[hydrothorax]]
-*[[Spontaneous bacterial peritonitis]]
 |-
-! align="center" style="background:#DCDCDC;" |[[Glycogen storage disease|Storage diseases]] (eg, [[Gaucher's disease|Gaucher]])
+! align="center" style="background:#DCDCDC;" |[[Seizure|Seizures]]
-| align="left" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
-* Splenomegaly
+| align="center" style="background:#F5F5F5;" + |
-* Bone marrow infiltration
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |Rare in children
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-* Family history
 | align="center" style="background:#F5F5F5;" + |
-* [[Rash|Skin rash]]
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
 | align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
@@ Line 768: / Line 956: @@
 | align="center" style="background:#F5F5F5;" + |
 |-
-! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Infections
+! rowspan="7" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Medication
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production
-sequestration/
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils
-redistribution
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
@@ Line 782: / Line 969: @@
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
 |-
-! align="center" style="background:#DCDCDC;" |[[Sepsis]]
+! align="center" style="background:#DCDCDC;" |[[Steroid|Steriod]]
-| align="left" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
-*Direct [[bone marrow suppression]]
+* Release of granulocytes from the bone marrow
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |Any
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-*[[Infection|Bacterial infection]]
 | align="center" style="background:#F5F5F5;" + |
-*[[Petechiae]]
-*[[Purpura]]
-*[[Erythema]]
-*[[Ulcer|Ulceration]]
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |±
-| align="center" style="background:#F5F5F5;" + |Nl to ↓
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |±
 | align="center" style="background:#F5F5F5;" + |
-*[[Malaise]]
-*[[Lymphadenopathy]]
-| align="center" style="background:#F5F5F5;" + |↓/↑
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓/↑
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
-| align="center" style="background:#F5F5F5;" + |NA
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + | +
-Depends on the etiology
-| align="center" style="background:#F5F5F5;" + |Clinical manifestation + culture
 | align="center" style="background:#F5F5F5;" + |
-*Associated with ↑ mortality
 |-
-! align="center" style="background:#DCDCDC;" |[[Infection|Viral infection]] such as [[Human Immunodeficiency Virus (HIV)|HIV]], [[hepatitis]], [[Epstein Barr virus|Epstein-Barr virus]]
+! align="center" style="background:#DCDCDC;" |Myeloid growth factors
-| align="left" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
-* Marrow suppression
+| align="center" style="background:#F5F5F5;" + |
-* Splenomegaly
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |Any
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-*High risk behaviors
-*Close contact
 | align="center" style="background:#F5F5F5;" + |
-*[[Petechiae]]
-*[[Purpura]]
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |±
-| align="center" style="background:#F5F5F5;" + |±
 | align="center" style="background:#F5F5F5;" + |
-*[[Lymphadenopathy]]
-*[[Muscle weakness]]
-*[[Joint swelling]]
-*Focal neurological deficits
-*Depends on etiology
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
 | align="center" style="background:#F5F5F5;" + |
-*[[Hematuria]]
-| align="center" style="background:#F5F5F5;" + |Clinical manifestation + lab tests
 | align="center" style="background:#F5F5F5;" + |
-*Depends on etiology
-*[[Encephalomyelitis]]
 |-
-! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Nutritional
+! align="center" style="background:#DCDCDC;" |[[Lithium]]
-! align="center" style="background:#DCDCDC;" |[[Macrocytic anemia|Megaloblastic anemia]]
+| align="center" style="background:#F5F5F5;" + |
-| align="left" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
-* Ineffective hematopoiesis
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Any
 | align="center" style="background:#F5F5F5;" + |
-*Malnutrition
-*Alcohol use
 | align="center" style="background:#F5F5F5;" + |
-* Normal
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
 | align="center" style="background:#F5F5F5;" + |
-*[[Fatigue]]
-*[[Weakness]]
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Laboratory findings
-| align="center" style="background:#F5F5F5;" + |NA
 |-
-! align="center" style="background:#DCDCDC;" |Excessive [[alcohol]]
+! align="center" style="background:#DCDCDC;" |[[Cytokine|Cytokines]]
-| align="left" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
-* Ineffective hematopoiesis
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |Alcoholism
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-*History of [[Alcoholism|alcohol use]]
 | align="center" style="background:#F5F5F5;" + |
-* Normal
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + | +
 | align="center" style="background:#F5F5F5;" + |
-*[[Hepatomegaly]]
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Clinical manifestation
 | align="center" style="background:#F5F5F5;" + |
-*[[Chronic liver disease]]
 |-
-! align="center" style="background:#DCDCDC;" |Other nutritional deficiency such as [[copper deficiency]], [[zinc]] toxicity
+! align="center" style="background:#DCDCDC;" |[[Catecholamine|Catecholamines]] ([[epinephrine]])
-| align="left" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
-* Ineffective hematopoiesis
+* Stimulation of bone marrow myelopoiesis
-| align="center" style="background:#F5F5F5;" + |−
+* Egress into the circulation
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |Any
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-*Malnutrition
-*Alcohol use
 | align="center" style="background:#F5F5F5;" + |
-* Normal
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
 | align="center" style="background:#F5F5F5;" + |
-*[[Fatigue]]
-*[[Weakness]]
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Laboratory findings
-| align="center" style="background:#F5F5F5;" + |NA
 |-
-! align="center" style="background:#DCDCDC;" |[[Malnutrition]]
+! align="center" style="background:#DCDCDC;" |[[Tretinoin|ATRA]]
-| align="left" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
-* Ineffective hematopoiesis
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |−
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + | +
+| align="center" style="background:#F5F5F5;" + |
-| align="center" style="background:#F5F5F5;" + |Any
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 | align="center" style="background:#F5F5F5;" + |
-*Malnutrition
-*Alcohol use
 | align="center" style="background:#F5F5F5;" + |
-* Normal
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
 | align="center" style="background:#F5F5F5;" + |
-*[[Fatigue]]
-*[[Weakness]]
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |Laboratory findings
-| align="center" style="background:#F5F5F5;" + |NA
-|-
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Medications
-! align="left" style="background:#DCDCDC;" |Medications such as:
-* [[Chemotherapy|Cytotoxic drugs]]
-* Idiosyncratic reactions to medications
-| align="left" style="background:#F5F5F5;" + |
-* Immune destruction
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Patients with [[Cancer|malignancy]]
 | align="center" style="background:#F5F5F5;" + |
-*[[Radiation therapy|Radiation]]
-*[[Cancer]]
 | align="center" style="background:#F5F5F5;" + |
-*[[Purpura]]
-*[[Petechia|Petechiae]]
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + | +
-| align="center" style="background:#F5F5F5;" + |Nl
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |−
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
-| align="center" style="background:#F5F5F5;" + |↓
 | align="center" style="background:#F5F5F5;" + |
-*[[Pancytopenia]]
 | align="center" style="background:#F5F5F5;" + |
-*Hypocellular [[bone marrow]]
-*Megakaryocytic hypoplasia or aplasia
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + |↑
-| align="center" style="background:#F5F5F5;" + |[[Hematuria case study one|Hematuria]]
-| align="center" style="background:#F5F5F5;" + |Clinical manifestation + exclusion of the other causes
 | align="center" style="background:#F5F5F5;" + |
-*[[Thrombosis]]
 |-
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
+! rowspan="10" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production
-sequestration/
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils
-redistribution
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
@@ Line 1,072: / Line 1,183: @@
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
-|}
-<references />
-*Leukocytosis is defined as an elevated white blood cell (WBC) count greater than 11,000 per mm3 (11.0 × 109 per L).
-*The most common type of leukocytosis is neutrophilia.
-**Neutrophilia can be defined as an increase in the absolute number of mature neutrophils to greater than 7,000 per mm3 [7.0 × 109 per L].
-{| class="wikitable"
-! colspan="3" |
-!Differentiating Symptoms
-!Differentiating physical exam findings
-!Differentiating Labs
 |-
-| rowspan="3" |'''Physiological variation'''
+! align="center" style="background:#DCDCDC;" |[[Allergy]]
-| colspan="2" |Birth
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 |-
-| colspan="2" |Adult
+! align="center" style="background:#DCDCDC;" |Post [[splenectomy]]
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 |-
-| colspan="2" |Pregnancy
+! align="center" style="background:#DCDCDC;" |[[Down syndrome]]
-|
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 |-
-| rowspan="6" |'''Primary'''
+! align="center" style="background:#DCDCDC;" |[[Smoking|Cigarette smoking]]
-| rowspan="4" |'''Congenital'''
+| align="center" style="background:#F5F5F5;" + |
-|Heridatary neutrophilia
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 |-
-|Chronic idiopathic neutrophilia
+! align="center" style="background:#DCDCDC;" |[[Stress (medicine)|Stress]]/[[Physical exercise|exercise]]
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 |-
-|Down syndrome
+! align="center" style="background:#DCDCDC;" |[[Infant|Infancy]]
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 |-
-|LAD
+! align="center" style="background:#DCDCDC;" |[[Pregnancy]]
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 |-
-| rowspan="2" |'''Acquired'''
+! align="center" style="background:#DCDCDC;" |[[Platelet]] clumping
-|CML
+| align="center" style="background:#F5F5F5;" + |Spurious
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 |-
-|Polycythemia Vera
+! align="center" style="background:#DCDCDC;" |[[Cryoglobulinemia|Mixed cryoglobulinemia]]
-|
+| align="center" style="background:#F5F5F5;" + |Spurious
-|
+| align="center" style="background:#F5F5F5;" + |
-|
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
+| align="center" style="background:#F5F5F5;" + |
 |-
-| rowspan="18" |'''Secondary'''
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
-| rowspan="2" |'''Infection'''
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
-|Acute
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physiologic
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous increased bone marrow production
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive increased bone marrow production
-|-
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demargination of peripheral blood neutrophils
-|Chronic
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
-|-
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance
-| rowspan="4" |'''Connective tissue disorders'''
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
-|RA
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal pain
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Asplenia
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatosplenomegaly
-|-
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lymphadenopathy
-|JRA
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Joint redness
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
-|-
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
-|IBD
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |ESR/CRP
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
-|-
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
-|Chronic hepatitis
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
-|
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
-|
-|
-|-
-| rowspan="4" |'''Drug induced'''
-|Steriod
-|
-|
-|
-|-
-|Lithium
-|
-|
-|
-|-
-|Beta agonists
-|
-|
-|
-|-
-|Cytokines
-|
-|
-|
-|-
-| rowspan="2" |'''Marrow stimulation'''
-|Hemolytic anemia
-|
-|
-|
-|-
-|Immature thrombocytopenia
-|
-|
-|
-|-
-| colspan="2" |'''Post splenectomy'''
-|
-|
-|
-|-
-| rowspan="5" |'''Metabolic'''
-|Diabetic coma
-|
-|
-|
-|-
-|Acidosis
-|
-|
-|
-|-
-|Thyroid strom
-|
-|
-|
-|-
-|Acute Gout
-|
-|
-|
-|-
-|Seizures
-|
-|
-|
 |}

Sandbox: wdx causes: Difference between revisions

Latest revision as of 21:38, 17 September 2018

Differentiating Leukocytosis from Other Diseases

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