SFRP4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Secreted frizzled-related protein 4''' is a [[protein]] that in humans is encoded by the ''SFRP4'' [[gene]].<ref name="pmid10211996">{{cite journal | vauthors = Abu-Jawdeh G, Comella N, Tomita Y, Brown LF, Tognazzi K, Sokol SY, Kocher O | title = Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy | journal = Lab Invest | volume = 79 | issue = 4 | pages = 439–47 |date=May 1999 | pmid = 10211996 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SFRP4 secreted frizzled-related protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6424| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Secreted frizzled-related protein 4
| HGNCid = 10778
| Symbol = SFRP4
| AltSymbols =; FRP-4; FRPHE; MGC26498
| OMIM = 606570
| ECnumber = 
| Homologene = 2267
| MGIid = 892010
| GeneAtlas_image1 = PBB_GE_SFRP4_204051_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SFRP4_204052_s_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007566 |text = embryo implantation}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6424
    | Hs_Ensembl = ENSG00000106483
    | Hs_RefseqProtein = NP_003005
    | Hs_RefseqmRNA = NM_003014
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 37912247
    | Hs_GenLoc_end = 37922903
    | Hs_Uniprot = Q6FHJ7
    | Mm_EntrezGene = 20379
    | Mm_Ensembl = ENSMUSG00000021319
    | Mm_RefseqmRNA = NM_016687
    | Mm_RefseqProtein = NP_057896
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 19630648
    | Mm_GenLoc_end = 19640286
    | Mm_Uniprot = Q9Z1N6
  }}
}}
'''Secreted frizzled-related protein 4''', also known as '''SFRP4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SFRP4 secreted frizzled-related protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6424| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Secreted [[frizzled]]-related protein 4 (SFRP4) is a member of the SFRP family that contains a [[cysteine]]-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of [[Wnt signaling]]. The expression of SFRP4 in [[ventricle (heart)|ventricular]] [[cardiac muscle|myocardium]] correlates with [[apoptosis]] related gene expression.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
SFRP4 is a hub gene in a [[Type 2 Diabetes]]-associated gene coexpression module in human [[Islets of Langerhans|islets]], and reduces glucose-induced insulin secretion through decreased [[Beta cell|β-cell]] [[exocytosis]]. Expression and release of SFRP4 from islets is enhanced by [[IL1B|interleukin-1β]]. SFRP4 is elevated in serum several years before clinical diagnosis of Type 2 Diabetes. Individuals who have above-average levels of SFRP4 in the blood are five times more likely to develop diabetes in the next few years than those with below-average levels.<ref name=Mahdi_2012>{{cite journal | vauthors = Mahdi T, Hänzelmann S, Salehi A, Muhammed SJ, Reinbothe TM, Tang Y, Axelsson AS, Zhou Y, Jing X, Almgren P, Krus U, Taneera J, Blom AM, Lyssenko V, ((Esguerra JLS)), Hansson O, Eliasson L, Derry J, Zhang E, Wollheim CB, Groop L, Renström E, Rosengren AH | title = Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes | journal = Cell Metabolism |date=November 2012 | volume = 16| issue = 5 | pages = 625–633 | doi = 10.1016/j.cmet.2012.10.009 | pmid=23140642}}</ref>
| summary_text = Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.<ref name="entrez">{{cite web | title = Entrez Gene: SFRP4 secreted frizzled-related protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6424| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
{{Clear}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Rattner A, Hsieh JC, Smallwood PM, etal |title=A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 7 |pages= 2859–63 |year= 1997 |pmid= 9096311 |doi=10.1073/pnas.94.7.2859  | pmc=20287 }}
| citations =
*{{cite journal   |vauthors=Wolf V, Ke G, Dharmarajan AM, etal |title=DDC-4, an apoptosis-associated gene, is a secreted frizzled relative. |journal=FEBS Lett. |volume=417 |issue= 3 |pages= 385–9 |year= 1998 |pmid= 9409757 |doi=10.1016/S0014-5793(97)01324-0 }}
*{{cite journal | author=Rattner A, Hsieh JC, Smallwood PM, ''et al.'' |title=A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 7 |pages= 2859-63 |year= 1997 |pmid= 9096311 |doi=  }}
*{{cite journal  | vauthors=Schumann H, Holtz J, Zerkowski HR, Hatzfeld M |title=Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression. |journal=Cardiovasc. Res. |volume=45 |issue= 3 |pages= 720–8 |year= 2000 |pmid= 10728394 |doi=10.1016/S0008-6363(99)00376-4 }}
*{{cite journal | author=Wolf V, Ke G, Dharmarajan AM, ''et al.'' |title=DDC-4, an apoptosis-associated gene, is a secreted frizzled relative. |journal=FEBS Lett. |volume=417 |issue= 3 |pages= 385-9 |year= 1998 |pmid= 9409757 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Abu-Jawdeh G, Comella N, Tomita Y, ''et al.'' |title=Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy. |journal=Lab. Invest. |volume=79 |issue= 4 |pages= 439-47 |year= 1999 |pmid= 10211996 |doi= }}
*{{cite journal   |vauthors=Berndt T, Craig TA, Bowe AE, etal |title=Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. |journal=J. Clin. Invest. |volume=112 |issue= 5 |pages= 785–94 |year= 2003 |pmid= 12952927 |doi= 10.1172/JCI18563  | pmc=182208 }}
*{{cite journal  | author=Schumann H, Holtz J, Zerkowski HR, Hatzfeld M |title=Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression. |journal=Cardiovasc. Res. |volume=45 |issue= 3 |pages= 720-8 |year= 2000 |pmid= 10728394 |doi=  }}
*{{cite journal   |vauthors=Wissmann C, Wild PJ, Kaiser S, etal |title=WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. |journal=J. Pathol. |volume=201 |issue= 2 |pages= 204–12 |year= 2003 |pmid= 14517837 |doi= 10.1002/path.1449 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Horvath LG, Henshall SM, Kench JG, etal |title=Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro. |journal=Clin. Cancer Res. |volume=10 |issue= 2 |pages= 615–25 |year= 2004 |pmid= 14760084 |doi=10.1158/1078-0432.CCR-0707-03 }}
*{{cite journal | author=Berndt T, Craig TA, Bowe AE, ''et al.'' |title=Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. |journal=J. Clin. Invest. |volume=112 |issue= 5 |pages= 785-94 |year= 2003 |pmid= 12952927 |doi= 10.1172/JCI200318563 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Wissmann C, Wild PJ, Kaiser S, ''et al.'' |title=WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. |journal=J. Pathol. |volume=201 |issue= 2 |pages= 204-12 |year= 2003 |pmid= 14517837 |doi= 10.1002/path.1449 }}
*{{cite journal   |vauthors=Ahn J, Chung KS, Kim DU, etal |title=Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. |journal=J. Biochem. Mol. Biol. |volume=37 |issue= 6 |pages= 741–8 |year= 2005 |pmid= 15607035 |doi=  10.5483/bmbrep.2004.37.6.741}}
*{{cite journal | author=Horvath LG, Henshall SM, Kench JG, ''et al.'' |title=Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro. |journal=Clin. Cancer Res. |volume=10 |issue= 2 |pages= 615-25 |year= 2004 |pmid= 14760084 |doi=  }}
*{{cite journal   |vauthors=He B, Lee AY, Dadfarmay S, etal |title=Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. |journal=Cancer Res. |volume=65 |issue= 3 |pages= 743–8 |year= 2005 |pmid= 15705870 |doi=  }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Berndt TJ, Bielesz B, Craig TA, etal |title=Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells. |journal=Pflügers Arch. |volume=451 |issue= 4 |pages= 579–87 |year= 2006 |pmid= 16151791 |doi= 10.1007/s00424-005-1495-2 }}
*{{cite journal | author=Ahn J, Chung KS, Kim DU, ''et al.'' |title=Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. |journal=J. Biochem. Mol. Biol. |volume=37 |issue= 6 |pages= 741-8 |year= 2005 |pmid= 15607035 |doi=  }}
*{{cite journal   |vauthors=Feng Han Q, Zhao W, Bentel J, etal |title=Expression of sFRP-4 and beta-catenin in human colorectal carcinoma. |journal=Cancer Lett. |volume=231 |issue= 1 |pages= 129–37 |year= 2006 |pmid= 16356838 |doi= 10.1016/j.canlet.2005.01.026 }}
*{{cite journal | author=He B, Lee AY, Dadfarmay S, ''et al.'' |title=Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. |journal=Cancer Res. |volume=65 |issue= 3 |pages= 743-8 |year= 2005 |pmid= 15705870 |doi=  }}
*{{cite journal   |vauthors=Urakami S, Shiina H, Enokida H, etal |title=Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2109–16 |year= 2006 |pmid= 16609023 |doi= 10.1158/1078-0432.CCR-05-2468 }}
*{{cite journal | author=Berndt TJ, Bielesz B, Craig TA, ''et al.'' |title=Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells. |journal=Pflugers Arch. |volume=451 |issue= 4 |pages= 579-87 |year= 2006 |pmid= 16151791 |doi= 10.1007/s00424-005-1495-2 }}
*{{cite journal   |vauthors=Horvath LG, Lelliott JE, Kench JG, etal |title=Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer. |journal=Prostate |volume=67 |issue= 10 |pages= 1081–90 |year= 2007 |pmid= 17476687 |doi= 10.1002/pros.20607 }}
*{{cite journal | author=Feng Han Q, Zhao W, Bentel J, ''et al.'' |title=Expression of sFRP-4 and beta-catenin in human colorectal carcinoma. |journal=Cancer Lett. |volume=231 |issue= 1 |pages= 129-37 |year= 2006 |pmid= 16356838 |doi= 10.1016/j.canlet.2005.01.026 }}
*{{cite journal | author=Urakami S, Shiina H, Enokida H, ''et al.'' |title=Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2109-16 |year= 2006 |pmid= 16609023 |doi= 10.1158/1078-0432.CCR-05-2468 }}
*{{cite journal | author=Horvath LG, Lelliott JE, Kench JG, ''et al.'' |title=Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer. |journal=Prostate |volume=67 |issue= 10 |pages= 1081-90 |year= 2007 |pmid= 17476687 |doi= 10.1002/pros.20607 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 16:07, 29 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Secreted frizzled-related protein 4 is a protein that in humans is encoded by the SFRP4 gene.[1][2]

Function

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.[2]

SFRP4 is a hub gene in a Type 2 Diabetes-associated gene coexpression module in human islets, and reduces glucose-induced insulin secretion through decreased β-cell exocytosis. Expression and release of SFRP4 from islets is enhanced by interleukin-1β. SFRP4 is elevated in serum several years before clinical diagnosis of Type 2 Diabetes. Individuals who have above-average levels of SFRP4 in the blood are five times more likely to develop diabetes in the next few years than those with below-average levels.[3]

References

  1. ↑ Abu-Jawdeh G, Comella N, Tomita Y, Brown LF, Tognazzi K, Sokol SY, Kocher O (May 1999). "Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy". Lab Invest. 79 (4): 439–47. PMID 10211996.
  2. ↑ 2.0 2.1 "Entrez Gene: SFRP4 secreted frizzled-related protein 4".
  3. ↑ Mahdi T, Hänzelmann S, Salehi A, Muhammed SJ, Reinbothe TM, Tang Y, Axelsson AS, Zhou Y, Jing X, Almgren P, Krus U, Taneera J, Blom AM, Lyssenko V, Esguerra JLS, Hansson O, Eliasson L, Derry J, Zhang E, Wollheim CB, Groop L, Renström E, Rosengren AH (November 2012). "Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes". Cell Metabolism. 16 (5): 625–633. doi:10.1016/j.cmet.2012.10.009. PMID 23140642.

Further reading


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