Retinoblastoma risk factors
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
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Overview
Common risk factors in the development of retinoblastoma are, advanced paternal age, positive family history, and viral exposure.
Common Risk Factors
Family History
Approximately 10% of patients with retinoblastoma have a previously established family history of the disease.
Viral exposure
The presence of HPV sequences in retinoblastoma tumor tissue may play a role in the development of sporadic retinoblastoma.
Advanced paternal age
There is evidence suggesting that the mutations of RB1 are more common during spermatogenesis than oogenesis.