RING1

Ring finger protein 1
File:PBB Protein RING1 image.jpg PDB rendering based on 2h0d.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2h0d​
Identifiers
Symbols	RING1 ; RNF1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68283
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RING1 35685 at tn.png
File:PBB GE RING1 208371 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ring finger protein 1, also known as RING1, is a human gene.

This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.

Further reading

• Hanson IM, Poustka A, Trowsdale J (1991). "New genes in the class II region of the human major histocompatibility complex". Genomics. 10 (2): 417–24. PMID 1906426.CS1 maint: Multiple names: authors list (link)
• Lovering R, Hanson IM, Borden KL; et al. (1993). "Identification and preliminary characterization of a protein motif related to the zinc finger". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2112–6. PMID 7681583.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Satijn DP, Gunster MJ, van der Vlag J; et al. (1997). "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Mol. Cell. Biol. 17 (7): 4105–13. PMID 9199346.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kikuti YY, Tamiya G, Ando A; et al. (1997). "Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes". Genomics. 42 (3): 422–35. doi:10.1006/geno.1997.4745. PMID 9205114.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Satijn DP, Otte AP (1999). "RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity". Mol. Cell. Biol. 19 (1): 57–68. PMID 9858531.
• García E, Marcos-Gutiérrez C, del Mar Lorente M; et al. (1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMID 10369680.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bárdos JI, Saurin AJ, Tissot C; et al. (2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J. Biol. Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Trimarchi JM, Fairchild B, Wen J, Lees JA (2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1519–24. doi:10.1073/pnas.041597698. PMID 11171983.CS1 maint: Multiple names: authors list (link)
• Dahiya A, Wong S, Gonzalo S; et al. (2001). "Linking the Rb and polycomb pathways". Mol. Cell. 8 (3): 557–69. PMID 11583618.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ogawa H, Ishiguro K, Gaubatz S; et al. (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6. doi:10.1126/science.1069861. PMID 12004135.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akasaka T, Takahashi N, Suzuki M; et al. (2003). "MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation". Genes Cells. 7 (8): 835–50. PMID 12167161.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Levine SS, Weiss A, Erdjument-Bromage H; et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Mol. Cell. Biol. 22 (17): 6070–8. PMID 12167701.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gil J, Bernard D, Martínez D, Beach D (2004). "Polycomb CBX7 has a unifying role in cellular lifespan". Nat. Cell Biol. 6 (1): 67–72. doi:10.1038/ncb1077. PMID 14647293.CS1 maint: Multiple names: authors list (link)
• Obuse C, Yang H, Nozaki N; et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. PMID 15009096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang H, Wang L, Erdjument-Bromage H; et al. (2004). "Role of histone H2A ubiquitination in Polycomb silencing". Nature. 431 (7010): 873–8. doi:10.1038/nature02985. PMID 15386022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qin H, Du D, Zhu Y; et al. (2005). "The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2". FEBS Lett. 579 (5): 1220–6. doi:10.1016/j.febslet.2005.01.022. PMID 15710417.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• RING1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.