Protein unc-119 homolog

Unc-119 homolog (C. elegans)
Identifiers
Symbols	UNC119 ; HRG4
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3778
Gene ontology Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE UNC119 203271 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Unc-119 homolog (C. elegans), also known as UNC119, is a human gene.

This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.

Further reading

• Higashide T, Murakami A, McLaren MJ, Inana G (1996). "Cloning of the cDNA for a novel photoreceptor protein". J. Biol. Chem. 271 (3): 1797–804. PMID 8576185.CS1 maint: Multiple names: authors list (link)
• Higashide T, McLaren MJ, Inana G (1998). "Localization of HRG4, a photoreceptor protein homologous to Unc-119, in ribbon synapse". Invest. Ophthalmol. Vis. Sci. 39 (5): 690–8. PMID 9538874.CS1 maint: Multiple names: authors list (link)
• Swanson DA, Chang JT, Campochiaro PA; et al. (1998). "Mammalian orthologs of C. elegans unc-119 highly expressed in photoreceptors". Invest. Ophthalmol. Vis. Sci. 39 (11): 2085–94. PMID 9761287.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Higashide T, Inana G (1999). "Characterization of the gene for HRG4 (UNC119), a novel photoreceptor synaptic protein homologous to unc-119". Genomics. 57 (3): 446–50. doi:10.1006/geno.1999.5791. PMID 10329014.
• Van Valkenburgh H, Shern JF, Sharer JD; et al. (2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID 11303027.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cen O, Gorska MM, Stafford SJ; et al. (2003). "Identification of UNC119 as a novel activator of SRC-type tyrosine kinases". J. Biol. Chem. 278 (10): 8837–45. doi:10.1074/jbc.M208261200. PMID 12496276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kobayashi A, Kubota S, Mori N; et al. (2004). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1–3): 26–32. PMID 12527357.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gorska MM, Stafford SJ, Cen O; et al. (2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. doi:10.1084/jem. 20030589 . PMID 14757743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vepachedu R, Gorska MM, Singhania N; et al. (2007). "Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway". J. Immunol. 179 (1): 682–90. PMID 17579091.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)