Protein unc-119 homolog

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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)n/an/a
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Protein unc-119 homolog A is a protein that in humans is encoded by the UNC119 gene.[1][2][3]


This gene is enriched in the photoreceptors of the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.[3]


Protein unc-119 homolog has been shown to interact with:


  1. Higashide T, Murakami A, McLaren MJ, Inana G (Mar 1996). "Cloning of the cDNA for a novel photoreceptor protein". J Biol Chem. 271 (3): 1797–804. doi:10.1074/jbc.271.3.1797. PMID 8576185.
  2. Higashide T, McLaren MJ, Inana G (Apr 1998). "Localization of HRG4, a photoreceptor protein homologous to Unc-119, in ribbon synapse". Invest Ophthalmol Vis Sci. 39 (5): 690–8. PMID 9538874.
  3. 3.0 3.1 "Entrez Gene: UNC119 unc-119 homolog (C. elegans)".
  4. Kobayashi A, Kubota S, Mori N, McLaren MJ, Inana G (Jan 2003). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1–3): 26–32. doi:10.1016/S0014-5793(02)03766-3. PMID 12527357.
  5. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  6. Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA (Jun 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID 11303027.
  7. 7.0 7.1 7.2 7.3 Gorska MM, Stafford SJ, Cen O, Sur S, Alam R (Feb 2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. doi:10.1084/jem.20030589. PMC 2211793. PMID 14757743.
  8. 8.0 8.1 Cen O, Gorska MM, Stafford SJ, Sur S, Alam R (Mar 2003). "Identification of UNC119 as a novel activator of SRC-type tyrosine kinases". J. Biol. Chem. 278 (10): 8837–45. doi:10.1074/jbc.M208261200. PMID 12496276.
  9. Alpadi K, Magupalli VG, Käppel S, Köblitz L, Schwarz K, Seigel GM, Sung CH, Schmitz F (2008). "RIBEYE recruits Munc119, a mammalian ortholog of the Caenorhabditis elegans protein unc119, to synaptic ribbons of photoreceptor synapses". J. Biol. Chem. 283 (39): 26461–7. doi:10.1074/jbc.M801625200. PMC 3258921. PMID 18664567.

Further reading