Prolactinoma causes: Difference between revisions

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==Causes==
==Causes==
There are no established causes for prolactinoma, although research continues to unravel the mysteries of disordered cell  growth, the cause of [[pituitary]] tumors remains unknown. It has been shown that stress can significantly raise [[prolactin]] levels which should make stress a [[diagnostic]] differential though it usually is not considered such. Most pituitary  tumors are sporadic--they are not genetically passed from parents to offspring. A minority of prolactinomas are associated with [[familial]] syndromes.
There are no established causes for prolactinoma. Most pituitary tumors are [[sporadic]]. A minority of prolactinomas are associated with [[familial]] syndromes.


===Familial Causes===
===Familial Causes===

Revision as of 13:57, 11 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]

Overview

There are no established causes for prolactinoma. Most pituitary tumors are sporadic--they are not genetically passed from parents to offspring.

Causes

There are no established causes for prolactinoma. Most pituitary tumors are sporadic. A minority of prolactinomas are associated with familial syndromes.

Familial Causes

Prolactinoma may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with:[1]

Other Causes

Other causes include:

  • The xenoestrogenic chemical Bisphenol-A has been shown to lead to hyperprolactinaemia and growth of prolactin-producing pituitary cells.[2] The increasing and prolonged exposure of Bisphenol-A from childhood may contribute to the growth of a prolactinoma.

References

  1. http://radiopaedia.org/articles/pituitary-adenoma
  2. ^ Goloubkova T, Ribeiro MF, Rodrigues LP, Cecconello AL, Spritzer PM (April 2000). "Effects of xenoestrogen bisphenol A on uterine and pituitary weight, serum prolactin levels and immunoreactive prolactin cells in ovariectomized Wistar rats". Arch. Toxicol. 74 (2): 92–8. doi:10.1007/s002040050658. PMID 10839476

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