Primary amenorrhea (patient information): Difference between revisions

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==Overview==
==Overview==
Amenorrhea is the absence of menstruation. Menstruation is a woman's monthly period.
Amenorrhea is the absence of [[menstruation]]. Menstruation is a woman's monthly period.


Primary amenorrhea is when a girl has not yet started her monthly periods, and she:
Primary amenorrhea is when a girl has not yet started her monthly periods, and she:
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==What causes Primary amenorrhea?==
==What causes Primary amenorrhea?==
Hormones play a big role in a woman's menstrual cycle. Hormone problems can occur when:
[[Hormones]] play a big role in a woman's [[menstrual cycle]]. Hormone problems can occur when:


*Changes occur to the parts of the brain where hormones that help manage the menstrual cycle are produced
*Changes occur to the parts of the [[brain]] where [[hormones]] that help manage the [[menstrual cycle]] are produced
*The ovaries are not working correctly
*The [[ovaries]] are not working correctly


These problems may be due to:
These problems may be due to:


*Genetic defects
*[[Genetic defects]]
*Infections that occur in the womb or after birth
*[[Infections]] that occur in the womb or after birth
*Other birth defects
*Other [[birth defects]]
*Tumors
*[[Tumor|Tumors]]


In many cases, the cause of primary amenorrhea is not known.
In many cases, the cause of primary amenorrhea is not known.
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*Adrenogenital syndrome
*Adrenogenital syndrome
*[[Anorexia nervosa (patient information)|Anorexia nervosa]]
*[[Anorexia nervosa (patient information)|Anorexia nervosa]]
*Chromosomal abnormalities such as [[Turner syndrome (patient information)|Turner syndrome]] or Sawyer syndrome
*[[Chromosomal]] abnormalities such as [[Turner syndrome (patient information)|Turner syndrome]] or Sawyer syndrome
*Congenital heart disease (cyanotic)
*[[Congenital heart disease]] (cyanotic)
*[[Congenital adrenal hyperplasia (patient information)|Congenital adrenal hyperplasia]]
*[[Congenital adrenal hyperplasia (patient information)|Congenital adrenal hyperplasia]]
* [[Craniopharyngioma (patient information)|Craniopharyngioma]]
* [[Craniopharyngioma (patient information)|Craniopharyngioma]]
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* [[Cushing's syndrome (patient information)|Cushing's disease]]
* [[Cushing's syndrome (patient information)|Cushing's disease]]
* [[Cystic fibrosis (patient information)|Cystic fibrosis]]
* [[Cystic fibrosis (patient information)|Cystic fibrosis]]
* Gonadal dysgenesis
* [[Gonadal dysgenesis]]
* [[Hypothyroidism (patient information)|Hypothyroidism]] and [[Hyperthyroidism (patient information)|hyperthyroidism]]
* [[Hypothyroidism (patient information)|Hypothyroidism]] and [[Hyperthyroidism (patient information)|hyperthyroidism]]
* Hypogonadotropic hypogonadism
* Hypogonadotropic [[hypogonadism]]
* [[Hyperprolactinemia]]
* [[Hyperprolactinemia]]
* [[Obesity]]
* [[Obesity]]
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* [[Androgen insensitivity syndrome (patient information)|Testicular feminization]]
* [[Androgen insensitivity syndrome (patient information)|Testicular feminization]]
* [[True hermaphroditism]]
* [[True hermaphroditism]]
* Tumors of the pituitary or adrenal glands
* [[Pituitary tumor|Tumors of the pituitary]] or [[Adrenal tumor (patient information)|adrenal glands]]
* [[Ovarian cancer (patient information)|Tumors of the ovaries]]
* [[Ovarian cancer (patient information)|Tumors of the ovaries]]


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Most girls begin menstruating between ages 9 and 18, with an average around 12 years old. Primary amenorrhea typically occurs when a girl is older than 15, if she has undergone other normal changes that occur during puberty. Primary amenorrhea may occur with or without other signs of puberty.
Most girls begin menstruating between ages 9 and 18, with an average around 12 years old. Primary amenorrhea typically occurs when a girl is older than 15, if she has undergone other normal changes that occur during puberty. Primary amenorrhea may occur with or without other signs of puberty.


Being born with poorly formed genital or pelvic organs (missing uterus or vagina, vaginal septum, cervical stenosis, or imperforate hymen) can lead to primary amenorrhea.
Being born with poorly formed [[genital]] or pelvic organs (missing uterus or vagina, [[vaginal septum]], cervical stenosis, or [[imperforate hymen]]) can lead to primary amenorrhea.


==When to seek urgent medical care?==
==When to seek urgent medical care?==
Call your health provider if your daughter is older than age 16 and has not yet begun menstruating, or if she is 14 and shows no other signs of puberty.\
Call your health provider if your daughter is older than age 16 and has not yet begun menstruating, or if she is 14 and shows no other signs of puberty.


==Diagnosis==
==Diagnosis==
The doctor will perform a physical exam and ask questions about your medical history. A pregnancy test will be done.
The doctor will perform a physical exam and ask questions about your medical history. A [[pregnancy test]] will be done.


Blood tests may include:
Blood tests may include:
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Other tests that may be done include:
Other tests that may be done include:


* 17 hydroxyprogesterone
* [[17-Hydroxyprogesterone|17 hydroxyprogesterone]]
* Chromosome analysis
* [[Chromosome]] analysis
* Head CT
* Head [[CT]]
* Head MRI scan
* Head [[MRI scan]]
* [[Laparoscopy]]
* [[Laparoscopy]]
* Pelvic ultrasound
* Pelvic [[ultrasound]]
* Progesterone withdrawal
* [[Progesterone]] withdrawal
* Serum progresterone
* Serum [[progresterone]]


==Treatment options==
==Treatment options==
Treatment depends on the cause of the missing period. Primary amenorrhea caused by birth defects may require medications (hormones), surgery, or both.
Treatment depends on the cause of the missing period. Primary amenorrhea caused by birth defects may require [[medications]] ([[hormones]]), [[surgery]], or both.


If the amenorrhea is caused by a tumor in the brain (pituitary tumor):
If the amenorrhea is caused by a [[tumor]] in the [[brain]] ([[pituitary tumor]]):


*Medications may shrink certain types of tumors.
*[[Medications]] may shrink certain types of tumors.
*Surgery to remove the tumor may also be necessary.
*[[Surgery]] to remove the tumor may also be necessary.
*Radiation therapy is usually only performed when other treatments have not worked.
*[[Radiation therapy]] is usually only performed when other treatments have not worked.


If the condition is caused by a body-wide (systemic) disease, treatment of the disease may allow menstruation to begin.
If the condition is caused by a body-wide (systemic) disease, treatment of the disease may allow menstruation to begin.


If the amenorrhea is due to low weight because of anorexia or too much exercise, periods will often begin when the weight returns to normal or the exercise level is decreased.
If the amenorrhea is due to low weight because of [[anorexia]] or too much exercise, periods will often begin when the weight returns to normal or the exercise level is decreased.


==Where to find medical care for Primary amenorrhea?==
==Where to find medical care for Primary amenorrhea?==
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* [[Congenital heart disease]]
* [[Congenital heart disease]]
* Drastic weight reduction
* Drastic weight reduction
* Hypogonadotropic hypogonadism
* Hypogonadotropic [[hypogonadism]]
* Imperforate hymen or vaginal septum
* [[Imperforate hymen]] or [[vaginal septum]]
* [[Malnutrition]]
* [[Malnutrition]]
* Normal delay of onset (up to age 14 or 15)
* Normal delay of onset (up to age 14 or 15)
* [[Obesity]]
* [[Obesity]]
* Overactive thyroid
* [[Overactive thyroid]]


Periods are unlikely to start on their own if the amenorrhea was caused by one of the following conditions:
Periods are unlikely to start on their own if the amenorrhea was caused by one of the following conditions:


* Congenital abnormalities of the upper genital system
* [[Congenital abnormalities]] of the upper genital system
* [[Craniopharyngioma (patient information)|Craniopharyngioma]]
* [[Craniopharyngioma (patient information)|Craniopharyngioma]]
* [[Cystic fibrosis (patient information)|Cystic fibrosis]]
* [[Cystic fibrosis (patient information)|Cystic fibrosis]]
* Gonadal dysgenesis
* [[Gonadal dysgenesis]]
* [[Prader-Willi syndrome (patient information)|Prader-Willi syndrome]]
* [[Prader-Willi syndrome (patient information)|Prader-Willi syndrome]]
* Testicular feminization syndrome
* [[Testicular feminization syndrome]]
* True hermaphroditism
* [[True hermaphroditism]]
* [[Turner syndrome (patient information)|Turner syndrome]] (XO)
* [[Turner syndrome (patient information)|Turner syndrome]] (XO)


If the amenorrhea cannot be corrected, it is sometimes possible to create a menstrual-like situation (pseudomenstruation) with medications. Medicines can help you feel more like your friends or family, and will also protect the bones from becoming too thin (osteoporosis).
If the amenorrhea cannot be corrected, it is sometimes possible to create a menstrual-like situation (pseudomenstruation) with [[medications]]. Medicines can help you feel more like your friends or family, and will also protect the bones from becoming too thin (osteoporosis).


==Possible complications==
==Possible complications==
*Emotional distress due to feeling different from friends or family, or worrying you might not be able to have children
*Emotional distress due to feeling different from friends or family, or worrying you might not be able to have children
*Osteoporosis and increased risk of fractures
*[[Osteoporosis]] and increased risk of fractures


==Sources==
==Sources==

Revision as of 16:48, 9 November 2017

Primary amenorrhea

Overview

What are the symptoms?

What are the causes?

Who is at highest risk?

When to seek urgent medical care?

Diagnosis

Treatment options

Where to find medical care for Primary amenorrhea?

What to expect (Outlook/Prognosis)?

Possible complications

Primary amenorrhea On the Web

Ongoing Trials at Clinical Trials.gov

Images of Primary amenorrhea

Videos on Primary amenorrhea

FDA on Primary amenorrhea

CDC on Primary amenorrhea

Primary amenorrhea in the news

Blogs on Primary amenorrhea

Directions to Hospitals Treating Primary amenorrhea

Risk calculators and risk factors for Primary amenorrhea

For the WikiDoc page for this topic, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Varun Kumar, M.B.B.S.

Overview

Amenorrhea is the absence of menstruation. Menstruation is a woman's monthly period.

Primary amenorrhea is when a girl has not yet started her monthly periods, and she:

Has gone through other normal changes that occur during puberty Is older than 15

What are the symptoms of Primary amenorrhea?

A female with amenorrhea will have no menstrual flow with or without other signs of puberty.

What causes Primary amenorrhea?

Hormones play a big role in a woman's menstrual cycle. Hormone problems can occur when:

These problems may be due to:

In many cases, the cause of primary amenorrhea is not known.

Conditions associated with primary amenorrhea include:

Who is at highest risk?

Most girls begin menstruating between ages 9 and 18, with an average around 12 years old. Primary amenorrhea typically occurs when a girl is older than 15, if she has undergone other normal changes that occur during puberty. Primary amenorrhea may occur with or without other signs of puberty.

Being born with poorly formed genital or pelvic organs (missing uterus or vagina, vaginal septum, cervical stenosis, or imperforate hymen) can lead to primary amenorrhea.

When to seek urgent medical care?

Call your health provider if your daughter is older than age 16 and has not yet begun menstruating, or if she is 14 and shows no other signs of puberty.

Diagnosis

The doctor will perform a physical exam and ask questions about your medical history. A pregnancy test will be done.

Blood tests may include:

Other tests that may be done include:

Treatment options

Treatment depends on the cause of the missing period. Primary amenorrhea caused by birth defects may require medications (hormones), surgery, or both.

If the amenorrhea is caused by a tumor in the brain (pituitary tumor):

  • Medications may shrink certain types of tumors.
  • Surgery to remove the tumor may also be necessary.
  • Radiation therapy is usually only performed when other treatments have not worked.

If the condition is caused by a body-wide (systemic) disease, treatment of the disease may allow menstruation to begin.

If the amenorrhea is due to low weight because of anorexia or too much exercise, periods will often begin when the weight returns to normal or the exercise level is decreased.

Where to find medical care for Primary amenorrhea?

Directions to Hospitals Treating Primary amenorrhea

What to expect (Outlook/Prognosis)?

Overall the outlook is good, depending on the cause of the amenorrhea. If the amenorrhea is caused by one of the following conditions, there is a good chance that it can be corrected with medication, lifestyle changes, or surgery:

Periods are unlikely to start on their own if the amenorrhea was caused by one of the following conditions:

If the amenorrhea cannot be corrected, it is sometimes possible to create a menstrual-like situation (pseudomenstruation) with medications. Medicines can help you feel more like your friends or family, and will also protect the bones from becoming too thin (osteoporosis).

Possible complications

  • Emotional distress due to feeling different from friends or family, or worrying you might not be able to have children
  • Osteoporosis and increased risk of fractures

Sources

http://www.nlm.nih.gov/medlineplus/ency/article/001218.htm

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