Polymyositis and dermatomyositis other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Overview

Other Diagnostic Studies

  • Electromyogram may be helpful in the diagnosis of polymyositis and dermatomyositis. Findings suggestive of polymyositis and dermatomyositis include:[1]
    •  Delay in electrical signals between the muscles and nerves when they are stimulated
    • Polyphasic, short, small motor-unit potentials
    • Fibrillation, positive sharp waves, increased insertional irritability
    • Bizarre, high-frequency, repetitive discharges
  • Electromyogram may also be used to
    • Identifying active sites of myositis for biopsy
    • Follow up the treatment efficacy. The first sign of improvement in polymyositis and dermatomyositis is the disappearance of fibrillation potentials.
    • Exclude all the other causes of denervations
  • Skin biopsy may be used in dermatomyositis,which demonstrates:
    • Poikiloderma
    • Epidermal atrophy
    • Liquefaction degeneration of the basal cells
    • Vascular dilatation
    • Lymphocytic infiltration of the dermis
  • Other diagnostic studies for [disease name] include:
    • Histochemical staining, which differentiate polymyositis and dermatomyositis from lower-motor-neuron diseases.
    • Skin biopsy, which demonstrates:
      • [Finding 1]
      • [Finding 2]
      • [Finding 3]

References

  1. Bohan, Anthony; Peter, James B. (1975). "Polymyositis and Dermatomyositis". New England Journal of Medicine. 292 (8): 403–407. doi:10.1056/NEJM197502202920807. ISSN 0028-4793.