Palmar plantar erythrodysesthesia medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Based on the severity of the condition, PPE can be managed by reducing the dose of chemotherapy, interruption of the agents, or switching to alternative antineoplastic chemotherapy which are less causative of PPE.[1]
The only method shown to effectively manage PPE are dose reduction and treatment suspension. Other supportive measure is also important to reduce pain and prevent secondary infection. Many different treatment strategies have been tested in case reports and retrospective studies, among which pyridoxine and COX-2 inhibitors are the most anticipated.[2]
Medical therapy
The goal is to continue chemotherapy while reducing symptoms of PPE. Symptomatic treatment includes pyridoxine, wound care, elevation, and pain medication (Vukelja et al 1993). Corticosteroids have also shown some efficacy in relieving symptoms.
References
- ↑ Janusch M, Fischer M, Marsch WCh, Holzhausen HJ, Kegel T, Helmbold P (2006). "The hand-foot syndrome--a frequent secondary manifestation in antineoplastic chemotherapy". Eur J Dermatol. 16 (5): 494–9. PMID 17101468.
- ↑ Gressett SM, Stanford BL, Hardwicke F (2006). "Management of hand-foot syndrome induced by capecitabine". J Oncol Pharm Pract. 12 (3): 131–41. doi:10.1177/1078155206069242. PMID 17022868.