PROX1: Difference between revisions

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Latest revision as of 17:04, 5 November 2018

Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene.^[1]^[2]

Interactions

PROX1 has been shown to interact with EP300.^[3]

Production

PROX1 is produced primarily in the dentate gyrus in the mouse, and in the dentate gyrus and white matter in humans. Gene expression data for mouse, human and macaque from the Allen Brain Atlases can be found here.

Clinical significance

PROX1 is used as a marker for lymphatic endothelium in biopsy samples.

References

↑ Zinovieva RD, Duncan MK, Johnson TR, Torres R, Polymeropoulos MH, Tomarev SI (Dec 1996). "Structure and chromosomal localization of the human homeobox gene Prox 1" (PDF). Genomics. 35 (3): 517–22. doi:10.1006/geno.1996.0392. PMID 8812486.
↑ "Entrez Gene: PROX1 prospero-related homeobox 1".
↑ Chen, Qin; Dowhan Dennis H; Liang Dongcai; Moore David D; Overbeek Paul A (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. United States. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. ISSN 0021-9258. PMID 11943779.

Wigle JT, Chowdhury K, Gruss P, Oliver G (1999). "Prox1 function is crucial for mouse lens-fibre elongation". Nat. Genet. 21 (3): 318–22. doi:10.1038/6844. PMID 10080188.
Mouta Carreira C, Nasser SM, di Tomaso E, et al. (2001). "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis". Cancer Res. 61 (22): 8079–84. PMID 11719431.
Rodriguez-Niedenführ M, Papoutsi M, Christ B, et al. (2002). "Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts". Anat. Embryol. 204 (5): 399–406. doi:10.1007/s00429-001-0214-9. PMID 11789987.
Duncan MK, Cui W, Oh DJ, Tomarev SI (2002). "Prox1 is differentially localized during lens development". Mech. Dev. 112 (1–2): 195–8. doi:10.1016/S0925-4773(01)00645-1. PMID 11850194.
Chen Q, Dowhan DH, Liang D, et al. (2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779.
Wilting J, Papoutsi M, Christ B, et al. (2002). "The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues". FASEB J. 16 (10): 1271–3. doi:10.1096/fj.01-1010fje. PMID 12060670.
Petrova TV, Mäkinen T, Mäkelä TP, et al. (2002). "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor". EMBO J. 21 (17): 4593–9. doi:10.1093/emboj/cdf470. PMC 125413. PMID 12198161.
Hong YK, Harvey N, Noh YH, et al. (2003). "Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate". Dev. Dyn. 225 (3): 351–7. doi:10.1002/dvdy.10163. PMID 12412020.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dyer MA, Livesey FJ, Cepko CL, Oliver G (2003). "Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina". Nat. Genet. 34 (1): 53–8. doi:10.1038/ng1144. PMID 12692551.
Nagai H, Li Y, Hatano S, et al. (2003). "Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies". Genes Chromosomes Cancer. 38 (1): 13–21. doi:10.1002/gcc.10248. PMID 12874782.
Steffensen KR, Holter E, Båvner A, et al. (2005). "Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue". EMBO Rep. 5 (6): 613–9. doi:10.1038/sj.embor.7400147. PMC 1299067. PMID 15143342.
Qin J, Gao DM, Jiang QF, et al. (2005). "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene". Mol. Endocrinol. 18 (10): 2424–39. doi:10.1210/me.2004-0009. PMID 15205472.
Dudas J, Papoutsi M, Hecht M, et al. (2005). "The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium". Anat. Embryol. 208 (5): 359–66. doi:10.1007/s00429-004-0403-4. PMID 15232737.
Reis RM, Reis-Filho JS, Longatto Filho A, et al. (2006). "Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors". Pathol. Res. Pract. 201 (12): 771–6. doi:10.1016/j.prp.2005.08.010. PMID 16308102.
Song KH, Li T, Chiang JY (2006). "A prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4 α that regulates the cholesterol 7α-hydroxylase gene". J. Biol. Chem. 281 (15): 10081–8. doi:10.1074/jbc.M513420200. PMC 1785292. PMID 16488887.
Schneider M, Büchler P, Giese N, et al. (2006). "Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread". Int. J. Oncol. 28 (4): 883–90. doi:10.3892/ijo.28.4.883. PMID 16525637.
Shimoda M, Takahashi M, Yoshimoto T, et al. (2006). "A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma". Clin. Cancer Res. 12 (20 Pt 1): 6005–11. doi:10.1158/1078-0432.CCR-06-0712. PMID 17062673.
Laerm A, Helmbold P, Goldberg M, et al. (2007). "Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system". J. Hepatol. 46 (1): 89–97. doi:10.1016/j.jhep.2006.07.033. PMID 17069925.

External links

PROX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[pmid8812486-1] Zinovieva RD, Duncan MK, Johnson TR, Torres R, Polymeropoulos MH, Tomarev SI (Dec 1996). "Structure and chromosomal localization of the human homeobox gene Prox 1" (PDF). Genomics. 35 (3): 517–22. doi:10.1006/geno.1996.0392. PMID 8812486.

[entrez-2] "Entrez Gene: PROX1 prospero-related homeobox 1".

[pmid11943779-3] Chen, Qin; Dowhan Dennis H; Liang Dongcai; Moore David D; Overbeek Paul A (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. United States. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. ISSN 0021-9258. PMID 11943779.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Prospero homeobox protein 1''' is a [[protein]] that in humans is encoded by the ''PROX1'' [[gene]].<ref name="pmid8812486">{{cite journal |vauthors=Zinovieva RD, Duncan MK, Johnson TR, Torres R, Polymeropoulos MH, Tomarev SI | title = Structure and chromosomal localization of the human homeobox gene Prox 1 | journal = Genomics | volume = 35 | issue = 3 | pages = 517–22 |date=Dec 1996 | pmid = 8812486 | pmc =  | doi = 10.1006/geno.1996.0392 | url =https://zenodo.org/record/1229697/files/article.pdf }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PROX1 prospero-related homeobox 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5629| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Prospero-related homeobox 1
- | HGNCid = 9459
- | Symbol = PROX1
- | AltSymbols =;
- | OMIM = 601546
- | ECnumber =
- | Homologene = 2069
- | MGIid = 97772
-  | GeneAtlas_image1 = PBB_GE_PROX1_207401_at_tn.png
- | Function =
- | Component =
- | Process =
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5629
-    | Hs_Ensembl = ENSG00000117707
-    | Hs_RefseqProtein = NP_002754
-    | Hs_RefseqmRNA = NM_002763
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 212228483
-    | Hs_GenLoc_end = 212281219
-    | Hs_Uniprot = Q92786
-    | Mm_EntrezGene = 19130
-    | Mm_Ensembl = ENSMUSG00000010175
-    | Mm_RefseqmRNA = NM_008937
-    | Mm_RefseqProtein = NP_032963
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 1
-    | Mm_GenLoc_start = 191822557
-    | Mm_GenLoc_end = 191863034
-    | Mm_Uniprot = P48437
-  }}
-}}
-'''Prospero-related homeobox 1''', also known as '''PROX1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PROX1 prospero-related homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5629| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
@@ Line 53: / Line 6: @@
 | summary_text =
 }}
+==Interactions==
+PROX1 has been shown to [[Protein-protein interaction|interact]] with [[EP300]].<ref name=pmid11943779>{{cite journal |last=Chen |first=Qin |authorlink= |author2=Dowhan Dennis H |author3=Liang Dongcai |author4=Moore David D |author5=Overbeek Paul A  |date=Jul 2002 |title=CREB-binding protein/p300 co-activation of crystallin gene expression |journal=J. Biol. Chem. |volume=277 |issue=27 |pages=24081–9 |publisher= |location = United States| issn = 0021-9258| pmid = 11943779 |doi = 10.1074/jbc.M201821200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
+==Production==
+PROX1 is produced primarily in the [[dentate gyrus]] in the mouse, and in the [[dentate gyrus]] and [[white matter]] in humans. Gene expression data for mouse, human and macaque from the [[Allen Brain Atlas]]es can be found [http://www.brain-map.org/search/index.html?query=prox1 here].
+==Clinical significance==
+PROX1 is used as a marker for [[lymphatic]] [[endothelium]] in biopsy samples.
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Zinovieva RD, Duncan MK, Johnson TR, ''et al.'' |title=Structure and chromosomal localization of the human homeobox gene Prox 1. |journal=Genomics |volume=35 |issue= 3 |pages= 517-22 |year= 1996 |pmid= 8812486 |doi= 10.1006/geno.1996.0392 }}
+*{{cite journal  |vauthors=Wigle JT, Chowdhury K, Gruss P, Oliver G |title=Prox1 function is crucial for mouse lens-fibre elongation. |journal=Nat. Genet. |volume=21 |issue= 3 |pages= 318–22 |year= 1999 |pmid= 10080188 |doi= 10.1038/6844 }}
-*{{cite journal  | author=Wigle JT, Chowdhury K, Gruss P, Oliver G |title=Prox1 function is crucial for mouse lens-fibre elongation. |journal=Nat. Genet. |volume=21 |issue= 3 |pages= 318-22 |year= 1999 |pmid= 10080188 |doi= 10.1038/6844 }}
+*{{cite journal  | author=Mouta Carreira C |title=LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis |journal=Cancer Res. |volume=61 |issue= 22 |pages= 8079–84 |year= 2001 |pmid= 11719431 |doi=  |name-list-format=vanc| author2=Nasser SM  | author3=di Tomaso E  | display-authors=3  | last4=Padera  | first4=TP  | last5=Boucher  | first5=Y  | last6=Tomarev  | first6=SI  | last7=Jain  | first7=RK  }}
-*{{cite journal  | author=Mouta Carreira C, Nasser SM, di Tomaso E, ''et al.'' |title=LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. |journal=Cancer Res. |volume=61 |issue= 22 |pages= 8079-84 |year= 2001 |pmid= 11719431 |doi=  }}
+*{{cite journal  | author=Rodriguez-Niedenführ M |title=Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts |journal=Anat. Embryol. |volume=204 |issue= 5 |pages= 399–406 |year= 2002 |pmid= 11789987 |doi=10.1007/s00429-001-0214-9  |name-list-format=vanc| author2=Papoutsi M  | author3=Christ B  | display-authors=3  | last4=Nicolaides  | first4=K. H.  | last5=Von Kaisenberg  | first5=C.S.  | last6=Tomarev  | first6=S. I.  | last7=Wilting  | first7=J.  }}
-*{{cite journal  | author=Rodriguez-Niedenführ M, Papoutsi M, Christ B, ''et al.'' |title=Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts. |journal=Anat. Embryol. |volume=204 |issue= 5 |pages= 399-406 |year= 2002 |pmid= 11789987 |doi=  }}
+*{{cite journal  |vauthors=Duncan MK, Cui W, Oh DJ, Tomarev SI |title=Prox1 is differentially localized during lens development |journal=Mech. Dev. |volume=112 |issue= 1–2 |pages= 195–8 |year= 2002 |pmid= 11850194 |doi=10.1016/S0925-4773(01)00645-1  }}
-*{{cite journal  | author=Duncan MK, Cui W, Oh DJ, Tomarev SI |title=Prox1 is differentially localized during lens development. |journal=Mech. Dev. |volume=112 |issue= 1-2 |pages= 195-8 |year= 2002 |pmid= 11850194 |doi=  }}
+*{{cite journal  | author=Chen Q |title=CREB-binding protein/p300 co-activation of crystallin gene expression |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24081–9 |year= 2002 |pmid= 11943779 |doi= 10.1074/jbc.M201821200  |name-list-format=vanc| author2=Dowhan DH  | author3=Liang D  | display-authors=3  | last4=Moore  | first4=DD  | last5=Overbeek  | first5=PA }}
-*{{cite journal  | author=Chen Q, Dowhan DH, Liang D, ''et al.'' |title=CREB-binding protein/p300 co-activation of crystallin gene expression. |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24081-9 |year= 2002 |pmid= 11943779 |doi= 10.1074/jbc.M201821200 }}
+*{{cite journal  | author=Wilting J |title=The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues |journal=FASEB J. |volume=16 |issue= 10 |pages= 1271–3 |year= 2002 |pmid= 12060670 |doi= 10.1096/fj.01-1010fje  |name-list-format=vanc| author2=Papoutsi M  | author3=Christ B  | display-authors=3  | last4=Nicolaides  | first4=KH  | last5=Von Kaisenberg  | first5=CS  | last6=Borges  | first6=J  | last7=Stark  | first7=GB  | last8=Alitalo  | first8=K  | last9=Tomarev  | first9=SI }}
-*{{cite journal  | author=Wilting J, Papoutsi M, Christ B, ''et al.'' |title=The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues. |journal=FASEB J. |volume=16 |issue= 10 |pages= 1271-3 |year= 2002 |pmid= 12060670 |doi= 10.1096/fj.01-1010fje }}
+*{{cite journal  | author=Petrova TV |title=Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor |journal=EMBO J. |volume=21 |issue= 17 |pages= 4593–9 |year= 2002 |pmid= 12198161 |doi=10.1093/emboj/cdf470  | pmc=125413  |name-list-format=vanc| author2=Mäkinen T  | author3=Mäkelä TP  | display-authors=3  | last4=Saarela  | first4=J  | last5=Virtanen  | first5=I  | last6=Ferrell  | first6=RE  | last7=Finegold  | first7=DN  | last8=Kerjaschki  | first8=D  | last9=Ylä-Herttuala  | first9=S  }}
-*{{cite journal  | author=Petrova TV, Mäkinen T, Mäkelä TP, ''et al.'' |title=Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. |journal=EMBO J. |volume=21 |issue= 17 |pages= 4593-9 |year= 2002 |pmid= 12198161 |doi=  }}
+*{{cite journal  | author=Hong YK |title=Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate |journal=Dev. Dyn. |volume=225 |issue= 3 |pages= 351–7 |year= 2003 |pmid= 12412020 |doi= 10.1002/dvdy.10163  |name-list-format=vanc| author2=Harvey N  | author3=Noh YH  | display-authors=3  | last4=Schacht  | first4=Vivien  | last5=Hirakawa  | first5=Satoshi  | last6=Detmar  | first6=Michael  | last7=Oliver  | first7=Guillermo }}
-*{{cite journal  | author=Hong YK, Harvey N, Noh YH, ''et al.'' |title=Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. |journal=Dev. Dyn. |volume=225 |issue= 3 |pages= 351-7 |year= 2003 |pmid= 12412020 |doi= 10.1002/dvdy.10163 }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  |vauthors=Dyer MA, Livesey FJ, Cepko CL, Oliver G |title=Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina |journal=Nat. Genet. |volume=34 |issue= 1 |pages= 53–8 |year= 2003 |pmid= 12692551 |doi= 10.1038/ng1144 }}
-*{{cite journal  | author=Dyer MA, Livesey FJ, Cepko CL, Oliver G |title=Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. |journal=Nat. Genet. |volume=34 |issue= 1 |pages= 53-8 |year= 2003 |pmid= 12692551 |doi= 10.1038/ng1144 }}
+*{{cite journal  | author=Nagai H |title=Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies |journal=Genes Chromosomes Cancer |volume=38 |issue= 1 |pages= 13–21 |year= 2003 |pmid= 12874782 |doi= 10.1002/gcc.10248  |name-list-format=vanc| author2=Li Y  | author3=Hatano S  | display-authors=3  | last4=Toshihito  | first4=Ohno  | last5=Yuge  | first5=Masayuki  | last6=Ito  | first6=Etsuro  | last7=Utsumi  | first7=Makoto  | last8=Saito  | first8=Hidehiko  | last9=Kinoshita  | first9=Tomohiro }}
-*{{cite journal  | author=Nagai H, Li Y, Hatano S, ''et al.'' |title=Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies. |journal=Genes Chromosomes Cancer |volume=38 |issue= 1 |pages= 13-21 |year= 2003 |pmid= 12874782 |doi= 10.1002/gcc.10248 }}
+*{{cite journal  | author=Steffensen KR |title=Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue |journal=EMBO Rep. |volume=5 |issue= 6 |pages= 613–9 |year= 2005 |pmid= 15143342 |doi= 10.1038/sj.embor.7400147  | pmc=1299067  |name-list-format=vanc| author2=Holter E  | author3=Båvner A  | display-authors=3  | last4=Nilsson  | first4=Maria  | last5=Pelto-Huikko  | first5=Markku  | last6=Tomarev  | first6=Stanislav  | last7=Treuter  | first7=Eckardt }}
-*{{cite journal  | author=Steffensen KR, Holter E, Båvner A, ''et al.'' |title=Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue. |journal=EMBO Rep. |volume=5 |issue= 6 |pages= 613-9 |year= 2005 |pmid= 15143342 |doi= 10.1038/sj.embor.7400147 }}
+*{{cite journal  | author=Qin J |title=Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene |journal=Mol. Endocrinol. |volume=18 |issue= 10 |pages= 2424–39 |year= 2005 |pmid= 15205472 |doi= 10.1210/me.2004-0009  |name-list-format=vanc| author2=Gao DM  | author3=Jiang QF  | display-authors=3  | last4=Zhou  | first4=Q  | last5=Kong  | first5=YY  | last6=Wang  | first6=Y  | last7=Xie  | first7=YH }}
-*{{cite journal  | author=Qin J, Gao DM, Jiang QF, ''et al.'' |title=Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene. |journal=Mol. Endocrinol. |volume=18 |issue= 10 |pages= 2424-39 |year= 2005 |pmid= 15205472 |doi= 10.1210/me.2004-0009 }}
+*{{cite journal  | author=Dudas J |title=The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium |journal=Anat. Embryol. |volume=208 |issue= 5 |pages= 359–66 |year= 2005 |pmid= 15232737 |doi= 10.1007/s00429-004-0403-4  |name-list-format=vanc| author2=Papoutsi M  | author3=Hecht M  | display-authors=3  | last4=Elmaouhoub  | first4=A.  | last5=Saile  | first5=B.  | last6=Christ  | first6=B.  | last7=Tomarev  | first7=S.I.  | last8=Kaisenberg  | first8=C.S.  | last9=Schweigerer  | first9=L. }}
-*{{cite journal  | author=Dudas J, Papoutsi M, Hecht M, ''et al.'' |title=The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium. |journal=Anat. Embryol. |volume=208 |issue= 5 |pages= 359-66 |year= 2005 |pmid= 15232737 |doi= 10.1007/s00429-004-0403-4 }}
+*{{cite journal  | author=Reis RM |title=Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors |journal=Pathol. Res. Pract. |volume=201 |issue= 12 |pages= 771–6 |year= 2006 |pmid= 16308102 |doi= 10.1016/j.prp.2005.08.010  |name-list-format=vanc| author2=Reis-Filho JS  | author3=Longatto Filho A  | display-authors=3  | last4=Tomarev  | first4=S  | last5=Silva  | first5=P  | last6=Lopes  | first6=J }}
-*{{cite journal  | author=Reis RM, Reis-Filho JS, Longatto Filho A, ''et al.'' |title=Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors. |journal=Pathol. Res. Pract. |volume=201 |issue= 12 |pages= 771-6 |year= 2006 |pmid= 16308102 |doi= 10.1016/j.prp.2005.08.010 }}
+*{{cite journal  |vauthors=Song KH, Li T, Chiang JY |title=A prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4 α that regulates the cholesterol 7α-hydroxylase gene |journal=J. Biol. Chem. |volume=281 |issue= 15 |pages= 10081–8 |year= 2006 |pmid= 16488887 |doi= 10.1074/jbc.M513420200  | pmc=1785292 }}
-*{{cite journal  | author=Song KH, Li T, Chiang JY |title=A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene. |journal=J. Biol. Chem. |volume=281 |issue= 15 |pages= 10081-8 |year= 2006 |pmid= 16488887 |doi= 10.1074/jbc.M513420200 }}
+*{{cite journal  | author=Schneider M |title=Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread |journal=Int. J. Oncol. |volume=28 |issue= 4 |pages= 883–90 |year= 2006 |pmid= 16525637 |doi=  10.3892/ijo.28.4.883|name-list-format=vanc| author2=Büchler P  | author3=Giese N  | display-authors=3  | last4=Giese  | first4=T  | last5=Wilting  | first5=J  | last6=Büchler  | first6=MW  | last7=Friess  | first7=H  }}
-*{{cite journal  | author=Schneider M, Büchler P, Giese N, ''et al.'' |title=Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread. |journal=Int. J. Oncol. |volume=28 |issue= 4 |pages= 883-90 |year= 2006 |pmid= 16525637 |doi=  }}
+*{{cite journal  | author=Shimoda M |title=A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma |journal=Clin. Cancer Res. |volume=12 |issue= 20 Pt 1 |pages= 6005–11 |year= 2006 |pmid= 17062673 |doi= 10.1158/1078-0432.CCR-06-0712  |name-list-format=vanc| author2=Takahashi M  | author3=Yoshimoto T  | display-authors=3  | last4=Kono  | first4=T.  | last5=Ikai  | first5=I.  | last6=Kubo  | first6=H. }}
-*{{cite journal  | author=Shimoda M, Takahashi M, Yoshimoto T, ''et al.'' |title=A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma. |journal=Clin. Cancer Res. |volume=12 |issue= 20 Pt 1 |pages= 6005-11 |year= 2006 |pmid= 17062673 |doi= 10.1158/1078-0432.CCR-06-0712 }}
+*{{cite journal  | author=Laerm A |title=Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system |journal=J. Hepatol. |volume=46 |issue= 1 |pages= 89–97 |year= 2007 |pmid= 17069925 |doi= 10.1016/j.jhep.2006.07.033  |name-list-format=vanc| author2=Helmbold P  | author3=Goldberg M  | display-authors=3  | last4=Dammann  | first4=R  | last5=Holzhausen  | first5=H  | last6=Ballhausen  | first6=W }}
-*{{cite journal  | author=Laerm A, Helmbold P, Goldberg M, ''et al.'' |title=Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system. |journal=J. Hepatol. |volume=46 |issue= 1 |pages= 89-97 |year= 2007 |pmid= 17069925 |doi= 10.1016/j.jhep.2006.07.033 }}
 }}
 {{refend}}
@@ Line 86: / Line 48: @@
 * {{MeshName|PROX1+protein,+human}}
-{{protein-stub}}
 {{NLM content}}
 {{Transcription factors}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}