POEMS syndrome history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Patients suffering from POEMS syndrome may have variable presentation and can present a diagnostic challenge for the clinician due to non-specific symtoms. Common symtoms of POEMS syndrome include numbness, tingling and weakness affecting extremities, fatigue, generalized pain in the body, foot drop, blurred vision, peripheral edema, dyspnea and hyperpigmentation. Less common symptoms include muscle weakness, diplopia, ocular pain and ascites.
History
Patients suffering from POEMS syndrome may have variable clinical presentations due to multi-system involvement. The median time from onset of symptoms to diagnosis of POEMS is 13 to 18 months. Presence of a combination of peripheral neuropathy, and monoclonal protein, particularly a lambda-restricted monoclonal gammopathy should raise the suspicion of POEMS syndrome.
Symptoms
Patients suffering from POEMS syndrome may have variable presentation and can present a diagnostic challenge for the clinician.
Common Symptoms
Common symptoms of POEMS syndrome include the following:[1][2]
- Numbness, tingling and weakness in the feet, later affecting the legs and hands
- Fatigue
- Generalized pain
- Foot drop
- Blurred vision
- Peripheral edema
- Dyspnea
- Hyperpigmentation
Less Common Symptoms
Less common symtoms of POEMS syndrome include the following:
- Muscle weakness
- Diplopia
- Ocular pain
- Ascites
- Erectile dysfunction
References
- ↑ Dispenzieri A (February 2014). "POEMS syndrome: 2014 update on diagnosis, risk-stratification, and management". Am. J. Hematol. 89 (2): 214–23. doi:10.1002/ajh.23644. PMID 24532337.
- ↑ Dispenzieri A, Buadi FK (December 2013). "A review of POEMS syndrome". Oncology (Williston Park, N.Y.). 27 (12): 1242–50. PMID 24624542.