Osteosarcoma natural history, complications and prognosis: Difference between revisions
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*Survival rates for patients with pelvic primary tumors are 20% to 47%. | *Survival rates for patients with pelvic primary tumors are 20% to 47%. | ||
*Complete surgical resection is associated with positive outcome for osteosarcoma of the pelvis. | *Complete surgical resection is associated with positive outcome for osteosarcoma of the pelvis. | ||
*Size of the primary tumor | ====Craniofacial/head and neck==== | ||
*In patients with craniofacial osteosarcoma, those with mandibular tumors have a significantly better prognosis than do patients with extragnathic tumors. | |||
===Size of the primary tumor=== | |||
===Metastatic disease=== | |||
After administration of preoperative chemotherapy, factors that influence outcome include the following: | After administration of preoperative chemotherapy, factors that influence outcome include the following: | ||
Revision as of 14:59, 22 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Prognosis
Pretreatment factors that influence outcome include the following:
Primary tumor site
Pelvis
- Survival rates for patients with pelvic primary tumors are 20% to 47%.
- Complete surgical resection is associated with positive outcome for osteosarcoma of the pelvis.
Craniofacial/head and neck
- In patients with craniofacial osteosarcoma, those with mandibular tumors have a significantly better prognosis than do patients with extragnathic tumors.
Size of the primary tumor
Metastatic disease
After administration of preoperative chemotherapy, factors that influence outcome include the following:
- Surgical resectability.
- Degree of tumor necrosis.
In general, prognostic factors in osteosarcoma have not been helpful in identifying patients who might benefit from treatment intensification or who might require less therapy while maintaining an excellent outcome.