Non small cell lung cancer chemotherapy: Difference between revisions
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==Overview== | ==Overview== | ||
==Chemotherapeutic regimens== | |||
Shown below is a table depicting the different choices of regimens for the initial or adjuvant chemotherapy of patients with non-small cell lung cancer. The list of regimens has been adapted from the 2014 NCCN Non-Small Cell Lung Cancer guidelines.<ref name="NCCN">http://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf</ref> | |||
===Cisplatin based therapy=== | |||
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! Agent !! Recommended regimen | |||
|- | |||
| [[Cisplatin]] 50 mg/m<sup>2</sup> + [[vinorelbine]] 25 mg/m<sup>2</sup> || [[Cisplatin]] on days 1 and 8, [[vinorelbine]] on days 1, 8, 15, 22 and every 28 days to a total of 4 cycles | |||
|- | |||
| [[Cisplatin]] 100 mg/m<sup>2</sup> + [[vinorelbine]] 30 mg/m<sup>2</sup> || [[Cisplatin]] on day 1, [[vinorelbine]] on days 1, 8, 15, 22 and every 28 days to a total of 4 cycles | |||
|- | |||
| [[Cisplatin]] 75-80 mg/m<sup>2</sup> + [[vinorelbine]] 25-50 mg/m<sup>2</sup> || [[Cisplatin]] on day 1, [[vinorelbine]] on days 1, 8 and every 21 days to a total of 4 cycles | |||
|- | |||
| [[Cisplatin]] 80 mg/m<sup>2</sup> + [[vinorelbine]] 4 mg/m<sup>2</sup> || [[Cisplatin]] on days 1, 22, 43, 64, then every 21 days to a total of 4 cycles, [[vinorelbine]] on days 1, 8, 15, 22, 29, every 2 weeks after day 43 until the completion of [[cisplatin]] treatmet | |||
|- | |||
| [[Cisplatin]] 100 mg/m<sup>2</sup> + [[etoposide]] 100 mg/m<sup>2</sup> || [[Cisplatin]] on day 1, [[etoposide]] through days 1 to 3 and every 28 days to a total of 4 cycles | |||
|- | |||
| [[Cisplatin]] 75 mg/m<sup>2</sup> + [[gemcitabine]] 1250 mg/m<sup>2</sup> || [[Cisplatin]] on day 1, [[gemcitabine]] on days 1, 8 and every 21 days to a total of 4 cycles | |||
|- | |||
| [[Cisplatin]] 75 mg/m<sup>2</sup> + [[docetaxel]] 75 mg/m<sup>2</sup> || [[Cisplatin]] on day 1, [[docetaxel]] on day 1 and every 21 days to a total of 4 cycles | |||
|- | |||
| [[Cisplatin]] 50 mg/m<sup>2</sup> + [[pemetrexed]] 500 mg/m<sup>2</sup> || [[Cisplatin]] on day 1, [[pemetrexed]] on days 1 and every 21 days to a total of 4 cycles | |||
|- | |||
|} | |||
===Alternative regimen: patients with comorbidities or can't tolerate cisplatin=== | |||
Paclitaxel 200 mg/m<sup>2</sup> on day 1 + carboplatin area under the concentration (AUC) 6 on day 1 and then every 21 days.<ref name="NCCN">http://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf</ref> | |||
==Chemotherapy plus radiotherapy regimens== | |||
===Chemotherapy plus radiotherapy=== | |||
The list bellow show the options for concomitant [[chemotherapy]] plus [[radiation therapy]] based on the 2014 NCCN Non-Small Cell Lung Cancer guidelines.<ref name="NCCN">http://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf</ref> | |||
*[[Cisplatin]] 50 mg/m<sup>2</sup> on days 1, 8, 29 and 36 + [[etoposide]] 50 mg/m<sup>2</sup> through days 1 to 5 and then 29 to 33 + thoracic radiotherapy | |||
*[[Cisplatin]] 100 mg/m<sup>2</sup> on days 1 and 29 + vinblastin 5 mg/m<sup>2</sup> weekly for 5 weeks + thoracic radiotherapy | |||
*[[Cisplatin]] 75 mg/m<sup>2</sup> on the first day + [[pemetrexed]] 500 mg/m<sup>2</sup> on day 1 and then every 21 days to a total of 3 cycles + thoracic radiotherapy | |||
*Carboplatin (AUC) 5 on the first day + [[pemetrexed]] 500 mg/m<sup>2</sup> on day 1 and then every 21 days to a total of 3 cycles + thoracic radiotherapy | |||
==References== | ==References== | ||
Revision as of 15:38, 24 June 2014
Template:Non small cell carcinoma of the lung Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alonso Alvarado, M.D. [2]
Overview
Chemotherapeutic regimens
Shown below is a table depicting the different choices of regimens for the initial or adjuvant chemotherapy of patients with non-small cell lung cancer. The list of regimens has been adapted from the 2014 NCCN Non-Small Cell Lung Cancer guidelines.[1]
Cisplatin based therapy
| Agent | Recommended regimen |
|---|---|
| Cisplatin 50 mg/m2 + vinorelbine 25 mg/m2 | Cisplatin on days 1 and 8, vinorelbine on days 1, 8, 15, 22 and every 28 days to a total of 4 cycles |
| Cisplatin 100 mg/m2 + vinorelbine 30 mg/m2 | Cisplatin on day 1, vinorelbine on days 1, 8, 15, 22 and every 28 days to a total of 4 cycles |
| Cisplatin 75-80 mg/m2 + vinorelbine 25-50 mg/m2 | Cisplatin on day 1, vinorelbine on days 1, 8 and every 21 days to a total of 4 cycles |
| Cisplatin 80 mg/m2 + vinorelbine 4 mg/m2 | Cisplatin on days 1, 22, 43, 64, then every 21 days to a total of 4 cycles, vinorelbine on days 1, 8, 15, 22, 29, every 2 weeks after day 43 until the completion of cisplatin treatmet |
| Cisplatin 100 mg/m2 + etoposide 100 mg/m2 | Cisplatin on day 1, etoposide through days 1 to 3 and every 28 days to a total of 4 cycles |
| Cisplatin 75 mg/m2 + gemcitabine 1250 mg/m2 | Cisplatin on day 1, gemcitabine on days 1, 8 and every 21 days to a total of 4 cycles |
| Cisplatin 75 mg/m2 + docetaxel 75 mg/m2 | Cisplatin on day 1, docetaxel on day 1 and every 21 days to a total of 4 cycles |
| Cisplatin 50 mg/m2 + pemetrexed 500 mg/m2 | Cisplatin on day 1, pemetrexed on days 1 and every 21 days to a total of 4 cycles |
Alternative regimen: patients with comorbidities or can't tolerate cisplatin
Paclitaxel 200 mg/m2 on day 1 + carboplatin area under the concentration (AUC) 6 on day 1 and then every 21 days.[1]
Chemotherapy plus radiotherapy regimens
Chemotherapy plus radiotherapy
The list bellow show the options for concomitant chemotherapy plus radiation therapy based on the 2014 NCCN Non-Small Cell Lung Cancer guidelines.[1]
- Cisplatin 50 mg/m2 on days 1, 8, 29 and 36 + etoposide 50 mg/m2 through days 1 to 5 and then 29 to 33 + thoracic radiotherapy
- Cisplatin 100 mg/m2 on days 1 and 29 + vinblastin 5 mg/m2 weekly for 5 weeks + thoracic radiotherapy
- Cisplatin 75 mg/m2 on the first day + pemetrexed 500 mg/m2 on day 1 and then every 21 days to a total of 3 cycles + thoracic radiotherapy
- Carboplatin (AUC) 5 on the first day + pemetrexed 500 mg/m2 on day 1 and then every 21 days to a total of 3 cycles + thoracic radiotherapy