Non-alcoholic fatty liver disease classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

NAFLD may be classified into non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH).

Classification

• Based on histology it is classified into the non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH).
• NAFL mostly considered as a benign condition but recent studies show it can progress to NASH up to 44%.
• The more severe form of NAFLD is called non-alcoholic steatohepatitis (NASH).
• One of the leading cause of cirrhosis in adults in united states is NASH. Almost 25 percent of adults with NASH may lead to cirrhosis.
• On the other hand, NASH progress to fibrosis that can lead to cirrhosis and hepatocellular cancer (HCC).
• Rate of progression does not correlate with body mass index (BMI) or hyperlipidemia