Non-alcoholic fatty liver disease primary prevention

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2] Parth Vikram Singh, MBBS[3]

Overview

Measures that may reduce MASLD development or progression include maintaining a healthy weight, reducing excess caloric intake, limiting ultraprocessed foods, saturated fats, refined sugars, and sugar-sweetened beverages, engaging in regular physical activity, avoiding alcohol intake, and effectively managing type 2 diabetes, obesity, dyslipidemia, and hypertension.

Primary Prevention

Effective measures for the primary prevention of non-alcoholic fatty liver disease include:

  • Eating a healthy diet that is rich in vegetables, fruits and healthy fats is the first and very important step.[1][2]
  • Regular exercise
  • Maintaining a healthy weight
  • Alcohol cessation
  • Compliant with medications
  • Patients must also be immunized for hepatitis A and B.

References

  1. Patil R, Sood GK (2017). "Non-alcoholic fatty liver disease and cardiovascular risk". World J Gastrointest Pathophysiol. 8 (2): 51–58. doi:10.4291/wjgp.v8.i2.51. PMC 5437502. PMID 28573067.
  2. Tilg H, Petta S, Stefan N, Targher G (January 2026). "Metabolic Dysfunction-Associated Steatotic Liver Disease in Adults: A Review". JAMA. 335 (2): 163–174. doi:10.1001/jama.2025.19615. PMID 41212550 Check |pmid= value (help).

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