NCOA6
| Nuclear receptor coactivator 6 | |||
|---|---|---|---|
| Identifiers | |||
| Symbols | NCOA6 ; HOXA7; ANTP; HOX1.1; PRIP; TRBP; AIB3; ASC2; KIAA0181; NRC; RAP250 | ||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 40920 | ||
| RNA expression pattern | |||
| File:PBB GE NCOA6 208979 at tn.png | |||
| More reference expression data | |||
| Orthologs | |||
| Template:GNF Ortholog box | |||
| Species | Human | Mouse | |
| Entrez | n/a | n/a | |
| Ensembl | n/a | n/a | |
| UniProt | n/a | n/a | |
| RefSeq (mRNA) | n/a | n/a | |
| RefSeq (protein) | n/a | n/a | |
| Location (UCSC) | n/a | n/a | |
| PubMed search | n/a | n/a | |
Nuclear receptor coactivator 6, also known as NCOA6, is a human gene.[1]
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.[1]
See also
References
Further reading
- Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.
- Carney JP, McKnight C, VanEpps S, Kelley MR (1995). "Random rapid amplification of cDNA ends (RRACE) allows for cloning of multiple novel human cDNA fragments containing (CAG)n repeats". Gene. 155 (2): 289–92. PMID 7536696.
- Nagase T, Seki N, Ishikawa K; et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. PMID 8724849.
- Guan XY, Xu J, Anzick SL; et al. (1996). "Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer". Cancer Res. 56 (15): 3446–50. PMID 8758910.
- Lee SK, Anzick SL, Choi JE; et al. (1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. PMID 10567404.
- Caira F, Antonson P, Pelto-Huikko M; et al. (2000). "Cloning and characterization of RAP250, a novel nuclear receptor coactivator". J. Biol. Chem. 275 (8): 5308–17. PMID 10681503.
- Zhu Y, Kan L, Qi C; et al. (2000). "Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR". J. Biol. Chem. 275 (18): 13510–6. PMID 10788465.
- Ko L, Cardona GR, Chin WW (2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212–7. PMID 10823961.
- Lee SK, Na SY, Jung SY; et al. (2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. 14 (6): 915–25. PMID 10847592.
- Mahajan MA, Samuels HH (2000). "A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein". Mol. Cell. Biol. 20 (14): 5048–63. PMID 10866662.
- Lee SK, Jung SY, Kim YS; et al. (2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. 15 (2): 241–54. PMID 11158331.
- Hong S, Lee MY, Cheong J (2001). "Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell". Biochem. Biophys. Res. Commun. 282 (5): 1257–62. doi:10.1006/bbrc.2001.4727. PMID 11302752.
- Iwasaki T, Chin WW, Ko L (2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol. Chem. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112.
- Zhu Y, Qi C, Cao WQ; et al. (2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10380–5. doi:10.1073/pnas.181347498. PMID 11517327.
- Jung DJ, Na SY, Na DS, Lee JW (2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi:10.1074/jbc.M110417200. PMID 11704680.
- Ko L, Cardona GR, Iwasaki T; et al. (2002). "Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs". Mol. Endocrinol. 16 (1): 128–40. PMID 11773444.
- Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Qi C, Chang J, Zhu Y; et al. (2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha". J. Biol. Chem. 277 (32): 28624–30. doi:10.1074/jbc.M201053200. PMID 12039952.
- Espejo F, Green M, Preece NE, Assa-Munt N (2003). "NMR assignment of human ASC2, a self contained protein interaction domain involved in apoptosis and inflammation". J. Biomol. NMR. 23 (2): 151–2. PMID 12153040.
External links
- NCOA6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.