NAD+ kinase
| NAD+ kinase | |
|---|---|
 Ribbon diagram of NAD+ kinase in complex with substrates. | |
| Identifiers | |
| Symbol | NADK |
| Entrez | 65220 |
| HUGO | 29831 |
| PDB | 1SUW |
| RefSeq | NP_075394.3 |
| UniProt | O95544 |
| Other data | |
| EC number | 2.7.1.23 |
| Locus | Chr. 1 p1p36.33 |
|
WikiDoc Resources for NAD+ kinase |
|
Articles |
|---|
|
Most recent articles on NAD+ kinase Most cited articles on NAD+ kinase |
|
Media |
|
Powerpoint slides on NAD+ kinase |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on NAD+ kinase at Clinical Trials.gov Clinical Trials on NAD+ kinase at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on NAD+ kinase
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on NAD+ kinase Discussion groups on NAD+ kinase Patient Handouts on NAD+ kinase Directions to Hospitals Treating NAD+ kinase Risk calculators and risk factors for NAD+ kinase
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for NAD+ kinase |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Overview
NAD+ kinase (EC 2.7.1.23, NADK) is an enzyme that converts nicotinamide adenine dinucleotide (NAD+) into NADP+, through phosphorylating the NAD+ coenzyme.[1] NADP+ is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis.[2] The structure of the NADK from the archaean Archaeoglobus fulgidus has been determined.[3]
Reaction
ATP + NAD(+) <=> ADP + NADP(+)
See also
References
- ↑ Magni G, Orsomando G, Raffaelli N (2006). "Structural and functional properties of NAD kinase, a key enzyme in NADP biosynthesis". Mini reviews in medicinal chemistry. 6 (7): 739–46. PMID 16842123.
- ↑ Pollak N, Dölle C, Ziegler M (2007). "The power to reduce: pyridine nucleotides--small molecules with a multitude of functions". Biochem. J. 402 (2): 205–18. PMID 17295611.
- ↑ Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH (2005). "Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP". J. Mol. Biol. 354 (2): 289–303. PMID 16242716.