Myxoma laboratory tests: Difference between revisions
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==Overview== | ==Overview== | ||
Laboratory findings consistent with cardiac myxoma include [[anemia]], [[leukocytosis]], and elevated [[erythrocyte sedimentation rate]]. However, these results are generally non-diagnostic. | [[Laboratory]] findings consistent with cardiac myxoma include [[anemia]], [[leukocytosis]], and elevated [[erythrocyte sedimentation rate]]. However, these results are generally non-diagnostic. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
The clinical utility of laboratory tests in the diagnosis of cardiac myxoma remains nonspecific.<ref name="pmid7477198">{{cite journal |vauthors=Reynen K |title=Cardiac myxomas |journal=N. Engl. J. Med. |volume=333 |issue=24 |pages=1610–7 |year=1995 |pmid=7477198 |doi=10.1056/NEJM199512143332407 |url=}}</ref> | The [[clinical]] utility of laboratory tests in the [[diagnosis]] of cardiac myxoma remains nonspecific. [[Laboratory]] findings consistent with cardiac myxoma include [[anemia]], [[leukocytosis]] and elevated [[erythrocyte sedimentation rate]].<ref name="pmid7477198">{{cite journal |vauthors=Reynen K |title=Cardiac myxomas |journal=N. Engl. J. Med. |volume=333 |issue=24 |pages=1610–7 |year=1995 |pmid=7477198 |doi=10.1056/NEJM199512143332407 |url=}}</ref> | ||
===Blood tests=== | ===Blood tests=== | ||
There is no specific blood test for the diagnosis of cardiac myxoma. However, constitutional symptoms are associated with the following blood count (CBC) findings:<ref name="pmid24599357">{{cite journal |vauthors=Hartig I, Kraatz EG, Beurich HW, Moosig F |title=[Atrial myxoma with clinical signs of systemic inflammatory disease.] |journal=Z Rheumatol |volume= |issue= |pages= |year=2014 |pmid=24599357 |doi=10.1007/s00393-013-1347-y |url=}}</ref> | There is no specific blood test for the diagnosis of cardiac myxoma. However, constitutional [[Symptom|symptoms]] are associated with the following [[Cell (biology)|cell blood count]] ([[Complete blood count|CBC]]) findings:<ref name="pmid24599357">{{cite journal |vauthors=Hartig I, Kraatz EG, Beurich HW, Moosig F |title=[Atrial myxoma with clinical signs of systemic inflammatory disease.] |journal=Z Rheumatol |volume= |issue= |pages= |year=2014 |pmid=24599357 |doi=10.1007/s00393-013-1347-y |url=}}</ref> | ||
*[[Anemia]] - Normochromic or hypochromic | *[[Anemia]] - [[Normochromic anemia|Normochromic]] or [[Hypochromic anemia|hypochromic]] | ||
*[[Leukocytosis]] | *[[Leukocytosis]] | ||
*Elevated [[erythrocyte sedimentation rate]] (ESR) | *Elevated [[erythrocyte sedimentation rate]] (ESR) | ||
*Elevated [[C-reactive protein]] | *Elevated [[C-reactive protein]] | ||
*Serum globulin level (hypergammaglobulinemia): A1-globulin serum levels can be found in patients with cardiac myxoma, and have been proposed as predictive markers of embolic accidents. <ref name="pmid10064362">{{cite journal |vauthors=Jelic J, Milicić D, Alfirević I, Anić D, Baudoin Z, Bulat C, Corić V, Dadić D, Husar J, Ivanćan V, Korda Z, Letica D, Predrijevac M, Ugljen R, Vućemilo I |title=Cardiac myxoma: diagnostic approach, surgical treatment and follow-up. A twenty years experience |journal=J Cardiovasc Surg (Torino) |volume=37 |issue=6 Suppl 1 |pages=113–7 |year=1996 |pmid=10064362 |doi= |url=}}</ref> | *Serum globulin level ([[hypergammaglobulinemia]]): | ||
*Serum [[IL-6]]: | **A1-globulin [[serum]] levels can be found in [[patients]] with cardiac myxoma, and have been proposed as predictive markers of [[embolic]] accidents. <ref name="pmid10064362">{{cite journal |vauthors=Jelic J, Milicić D, Alfirević I, Anić D, Baudoin Z, Bulat C, Corić V, Dadić D, Husar J, Ivanćan V, Korda Z, Letica D, Predrijevac M, Ugljen R, Vućemilo I |title=Cardiac myxoma: diagnostic approach, surgical treatment and follow-up. A twenty years experience |journal=J Cardiovasc Surg (Torino) |volume=37 |issue=6 Suppl 1 |pages=113–7 |year=1996 |pmid=10064362 |doi= |url=}}</ref> | ||
*Serum [[IL-6]]: | |||
**Atrial myxoma cells are capable of producing [[Interleukin 6|Interleukin-6]] [[IL-6|(IL-6]]). Consequently, [[IL-6]] is used as a marker of recurrence in cardiac myxomas.<ref name="pmid26351445">{{cite journal |vauthors=Ezerioha N, Feng W |title=Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 |journal=Case Rep Neurol |volume=7 |issue=2 |pages=152–5 |year=2015 |pmid=26351445 |pmc=4560324 |doi=10.1159/000437256 |url=}}</ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]Maria Fernanda Villarreal, M.D. [3]
Overview
Laboratory findings consistent with cardiac myxoma include anemia, leukocytosis, and elevated erythrocyte sedimentation rate. However, these results are generally non-diagnostic.
Laboratory Findings
The clinical utility of laboratory tests in the diagnosis of cardiac myxoma remains nonspecific. Laboratory findings consistent with cardiac myxoma include anemia, leukocytosis and elevated erythrocyte sedimentation rate.[1]
Blood tests
There is no specific blood test for the diagnosis of cardiac myxoma. However, constitutional symptoms are associated with the following cell blood count (CBC) findings:[2]
- Anemia - Normochromic or hypochromic
- Leukocytosis
- Elevated erythrocyte sedimentation rate (ESR)
- Elevated C-reactive protein
- Serum globulin level (hypergammaglobulinemia):
- Serum IL-6:
- Atrial myxoma cells are capable of producing Interleukin-6 (IL-6). Consequently, IL-6 is used as a marker of recurrence in cardiac myxomas.[4]
References
- ↑ Reynen K (1995). "Cardiac myxomas". N. Engl. J. Med. 333 (24): 1610–7. doi:10.1056/NEJM199512143332407. PMID 7477198.
- ↑ Hartig I, Kraatz EG, Beurich HW, Moosig F (2014). "[Atrial myxoma with clinical signs of systemic inflammatory disease.]". Z Rheumatol. doi:10.1007/s00393-013-1347-y. PMID 24599357.
- ↑ Jelic J, Milicić D, Alfirević I, Anić D, Baudoin Z, Bulat C, Corić V, Dadić D, Husar J, Ivanćan V, Korda Z, Letica D, Predrijevac M, Ugljen R, Vućemilo I (1996). "Cardiac myxoma: diagnostic approach, surgical treatment and follow-up. A twenty years experience". J Cardiovasc Surg (Torino). 37 (6 Suppl 1): 113–7. PMID 10064362.
- ↑ Ezerioha N, Feng W (2015). "Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6". Case Rep Neurol. 7 (2): 152–5. doi:10.1159/000437256. PMC 4560324. PMID 26351445.