Multiple myeloma causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Shyam Patel [3]

Overview

The causes of multiple myeloma include sporadic mutations, such as TP53 mutation, and inherited predisposition.

Causes

Common causes

The causes of multiple myeloma include:

  • Sporadic mutations and genetic predisposition
  • Mutations in tumor suppressors or oncogenes
  • Mutations in the tumor suppressor TP53 (most common)
  • Chromosomal aberrations such as translocations can trigger the onset of malignancy and allow for uncontrolled plasma cell proliferation.[1]

Less common causes

  • Familial causes are less contributory to the development of multiple myeloma compared to sporadic causes.[1]

References

  1. 1.0 1.1 Rajkumar SV (2016). "Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management". Am J Hematol. 91 (7): 719–34. doi:10.1002/ajh.24402. PMC 5291298. PMID 27291302.