Multiple endocrine neoplasia type 2 risk factors
Multiple endocrine neoplasia type 2 Microchapters |
Differentiating Multiple endocrine neoplasia type 2 from other Diseases |
---|
Diagnosis |
Treatment |
Multiple endocrine neoplasia type 2 risk factors On the Web |
American Roentgen Ray Society Images of Multiple endocrine neoplasia type 2 risk factors |
Multiple endocrine neoplasia type 2 risk factors in the news |
Directions to Hospitals Treating Multiple endocrine neoplasia type 2 |
Risk calculators and risk factors for Multiple endocrine neoplasia type 2 risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [3]
Overview
Common risk factor in the development of multiple endocrine neoplasia type 2 is family history.
Risk Factors
- Family history is the common risk factor in the development of multiple endocrine neoplasia type 2..[1]
- During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999 [6], the risk of MTC has been stratified in three categories according to the mutations of c-RET as following.
Gene | Risk |
---|---|
Children with MEN2B and/or c-RET codon 883, 918,
922 |
Highest risk of aggressive medullary thyroid cancer |
Children with any c-RET codon 611, 618, 620 or 634
mutations |
High risk of medullary thyroid cancer |
Children with c-RET codon 609, 768, 790, 791, 804
and 891 mutations |
Less aggressive and slowly growing medullary thyroid cancer |