Multiple endocrine neoplasia type 2 risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Family history is the most common risk factor in the development of multiple endocrine neoplasia type 2.
Risk Factors
- Family history is the most common risk factor in the development of multiple endocrine neoplasia type 2.[1][2][3][4]
- In 1999, during the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio , the risk of medullary thyroid cancer has been stratified in three categories according to the mutations of c-RET as following.[5][3]
Gene | Risk |
---|---|
Children with multiple endocrine neoplasia type 2B and/or c-RET codon 883, 918,
922 |
Highest risk of aggressive medullary thyroid cancer |
Children with any c-RET codon 611, 618, 620 or 634
mutations |
High risk of medullary thyroid cancer |
Children with c-RET codon 609, 768, 790, 791, 804
and 891 mutations |
Less aggressive and slowly growing medullary thyroid cancer |
Adapted from Marquard J, Eng C. Multiple Endocrine Neoplasia Type 2. 1999 Sep 27 [Updated 2015 Jun 25]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1257/[6] |
References
- ↑ Yip, Linwah (2003). "Multiple Endocrine Neoplasia Type 2". Archives of Surgery. 138 (4): 409. doi:10.1001/archsurg.138.4.409. ISSN 0004-0010.
- ↑ Multiple endocrine neoplasia type2. Orphanet (30.10.2015). http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=653 Accessed on October, 30, 2015
- ↑ 3.0 3.1 Marini, Francesca; Falchetti, Alberto; Del Monte, Francesca; Carbonell Sala, Silvia; Tognarini, Isabella; Luzi, Ettore; Brandi, Maria (2006). Orphanet Journal of Rare Diseases. 1 (1): 45. doi:10.1186/1750-1172-1-45. ISSN 1750-1172. Missing or empty
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(help) - ↑ Friedhelm Raue & Karin Frank-Raue (2012). "Genotype-phenotype correlation in multiple endocrine neoplasia type 2". Clinics (Sao Paulo, Brazil). 67 Suppl 1: 69–75. doi:10.6061/clinics/2012(sup01)13. PMID 22584709.
- ↑ Liu, Qiuli; Tong, Dali; Yuan, Wenqiang; Liu, Gaolei; Yuan, Gang; Lan, Weihua; Zhang, Dianzheng; Zhang, Jun; Huang, Zaoming; Zhang, Yao; Jiang, Jun (2017). "Different RET gene mutation-induced multiple endocrine neoplasia type 2A in 3 Chinese families". Medicine. 96 (3): e5967. doi:10.1097/MD.0000000000005967. ISSN 0025-7974.
- ↑ Jessica Marquard & Charis Eng (1993). "Multiple Endocrine Neoplasia Type 2". PMID 020301434.