Multiple endocrine neoplasia type 2 risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [3]
Overview
Common risk factor in the development of multiple endocrine neoplasia type 2 is family history.
Risk Factors
- Family history is the common risk factor in the development of multiple endocrine neoplasia type 2.[1]
- During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999, the risk of medullary thyroid cancer has been stratified in three categories according to the mutations of c-RET as following.
Gene | Risk | ||
---|---|---|---|
Children with multiple endocrine neoplasia type 2B and/or c-RET codon 883, 918,
922 |
Highest risk of aggressive medullary thyroid cancer | ||
Children with any c-RET codon 611, 618, 620 or 634
mutations |
High risk of medullary thyroid cancer | ||
Children with c-RET codon 609, 768, 790, 791, 804
and 891 mutations |
Less aggressive and slowly growing medullary thyroid cancer- | Adapted from Marquard J, Eng C. Multiple Endocrine Neoplasia Type 2. 1999 Sep 27 [Updated 2015 Jun 25]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1257/[2] |
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References
- ↑ [1] Wikipedia Multiple endocrine neoplasia type 2; MEN2
- ↑ Jessica Marquard & Charis Eng (1993). "Multiple Endocrine Neoplasia Type 2". PMID 020301434.