Multiple endocrine neoplasia type 2 risk factors: Difference between revisions
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<small>Adapted from Marquard J, Eng C. Multiple Endocrine Neoplasia Type 2. 1999 Sep 27 [Updated 2015 Jun 25]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1257/<ref> | |||
==References== | ==References== |
Revision as of 11:34, 25 June 2019
Multiple endocrine neoplasia type 2 Microchapters |
Differentiating Multiple endocrine neoplasia type 2 from other Diseases |
---|
Diagnosis |
Treatment |
Multiple endocrine neoplasia type 2 risk factors On the Web |
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Multiple endocrine neoplasia type 2 risk factors in the news |
Directions to Hospitals Treating Multiple endocrine neoplasia type 2 |
Risk calculators and risk factors for Multiple endocrine neoplasia type 2 risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Family history is the most common risk factor in the development of multiple endocrine neoplasia type 2.
Risk Factors
- Family history is the most common risk factor in the development of multiple endocrine neoplasia type 2.
- In 1999, during the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio , the risk of medullary thyroid cancer has been stratified in three categories according to the mutations of c-RET as following.
Gene | Risk |
---|---|
Children with multiple endocrine neoplasia type 2B and/or c-RET codon 883, 918,
922 |
Highest risk of aggressive medullary thyroid cancer |
Children with any c-RET codon 611, 618, 620 or 634
mutations |
High risk of medullary thyroid cancer |
Children with c-RET codon 609, 768, 790, 791, 804
and 891 mutations |
Less aggressive and slowly growing medullary thyroid cancer |
Adapted from Marquard J, Eng C. Multiple Endocrine Neoplasia Type 2. 1999 Sep 27 [Updated 2015 Jun 25]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1257/[1] |
Adapted from Marquard J, Eng C. Multiple Endocrine Neoplasia Type 2. 1999 Sep 27 [Updated 2015 Jun 25]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1257/<ref>
References
- ↑ Jessica Marquard & Charis Eng (1993). "Multiple Endocrine Neoplasia Type 2". PMID 020301434.