Multiple endocrine neoplasia type 2 risk factors: Difference between revisions

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Revision as of 00:50, 29 September 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [3]

Common risk factor in the development of multiple endocrine neoplasia type 2 is family history.

Family history is the common risk factor in the development of multiple endocrine neoplasia type 2.^[1]
During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999, the risk of medullary thyroid cancer has been stratified in three categories according to the mutations of c-RET as following.

**Risk Stratification**
Gene	Risk
Children with multiple endocrine neoplasia type 2B and/or c-RET codon 883, 918, 922	Highest risk of aggressive medullary thyroid cancer
Children with any c-RET codon 611, 618, 620 or 634 mutations	High risk of medullary thyroid cancer
Children with c-RET codon 609, 768, 790, 791, 804 and 891 mutations	Less aggressive and slowly growing medullary thyroid cancer
Adapted from Marquard J, Eng C. Multiple Endocrine Neoplasia Type 2. 1999 Sep 27 [Updated 2015 Jun 25]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1257/^[2]

↑ [1] Wikipedia Multiple endocrine neoplasia type 2; MEN2
↑ Jessica Marquard & Charis Eng (1993). "Multiple Endocrine Neoplasia Type 2". PMID 020301434.

@@ Line 22: / Line 22: @@
 ! style="background: #F5F5F5;" | Children with c-''RET'' codon 609, 768, 790, 791, 804
 and 891 mutations
-! style="background: #F5F5F5;" | Less aggressive and slowly growing [[medullary thyroid cancer]]-
+! style="background: #F5F5F5;" | Less aggressive and slowly growing [[medullary thyroid cancer]]
+|-
 | style="padding: 5px 5px; background: #F5F5F5;" colspan="2"|<small>Adapted from Marquard J, Eng C. Multiple Endocrine Neoplasia Type 2. 1999 Sep 27 [Updated 2015 Jun 25]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1257/<ref>{{Cite journal| author = [[Jessica Marquard]] & [[Charis Eng]]
   | title = Multiple Endocrine Neoplasia Type 2
@@ Line 29: / Line 30: @@
   | pmid = 020301434
 }}</ref>
-|}
 |}