Multiple endocrine neoplasia type 2 risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
Family history is the most common risk factor in the development of multiple endocrine neoplasia type 2. | |||
==Risk Factors== | ==Risk Factors== | ||
* [[Family history]] is the common risk factor in the development of multiple endocrine neoplasia type 2.<ref>[https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia_type_2] Wikipedia Multiple endocrine neoplasia type 2; MEN2</ref> | * [[Family history]] is the most common risk factor in the development of multiple endocrine neoplasia type 2.<ref>[https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia_type_2] Wikipedia Multiple endocrine neoplasia type 2; MEN2</ref> | ||
* During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999, the risk of medullary thyroid cancer has been stratified in three categories according to the mutations of c-''RET'' as following. | * During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999, the risk of medullary thyroid cancer has been stratified in three categories according to the mutations of c-''RET'' as following. | ||
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Revision as of 00:44, 5 October 2015
Multiple endocrine neoplasia type 2 Microchapters |
Differentiating Multiple endocrine neoplasia type 2 from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [3]
Overview
Family history is the most common risk factor in the development of multiple endocrine neoplasia type 2.
Risk Factors
- Family history is the most common risk factor in the development of multiple endocrine neoplasia type 2.[1]
- During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999, the risk of medullary thyroid cancer has been stratified in three categories according to the mutations of c-RET as following.
Gene | Risk |
---|---|
Children with multiple endocrine neoplasia type 2B and/or c-RET codon 883, 918,
922 |
Highest risk of aggressive medullary thyroid cancer |
Children with any c-RET codon 611, 618, 620 or 634
mutations |
High risk of medullary thyroid cancer |
Children with c-RET codon 609, 768, 790, 791, 804
and 891 mutations |
Less aggressive and slowly growing medullary thyroid cancer |
Adapted from Marquard J, Eng C. Multiple Endocrine Neoplasia Type 2. 1999 Sep 27 [Updated 2015 Jun 25]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1257/[2] |
References
- ↑ [1] Wikipedia Multiple endocrine neoplasia type 2; MEN2
- ↑ Jessica Marquard & Charis Eng (1993). "Multiple Endocrine Neoplasia Type 2". PMID 020301434.