Multiple endocrine neoplasia type 2 risk factors: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 22: | Line 22: | ||
! style="background: #F5F5F5;" | Children with c-''RET'' codon 609, 768, 790, 791, 804 | ! style="background: #F5F5F5;" | Children with c-''RET'' codon 609, 768, 790, 791, 804 | ||
and 891 mutations | and 891 mutations | ||
! style="background: #F5F5F5;" | Less aggressive and slowly growing [[medullary thyroid cancer]] | ! style="background: #F5F5F5;" | Less aggressive and slowly growing [[medullary thyroid cancer]]- | ||
| style="padding: 5px 5px; background: #F5F5F5;" colspan="2"|<small>Adapted from Marquard J, Eng C. Multiple Endocrine Neoplasia Type 2. 1999 Sep 27 [Updated 2015 Jun 25]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1257/<ref>{{Cite journal| author = [[Jessica Marquard]] & [[Charis Eng]] | |||
| title = Multiple Endocrine Neoplasia Type 2 | |||
| year = 1993 | |||
| month = | |||
| pmid = 020301434 | |||
}}</ref> | |||
|} | |} | ||
|} | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 00:49, 29 September 2015
|
Multiple endocrine neoplasia type 2 Microchapters |
|
Differentiating Multiple endocrine neoplasia type 2 from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Multiple endocrine neoplasia type 2 risk factors On the Web |
|
American Roentgen Ray Society Images of Multiple endocrine neoplasia type 2 risk factors |
|
Multiple endocrine neoplasia type 2 risk factors in the news |
|
Directions to Hospitals Treating Multiple endocrine neoplasia type 2 |
|
Risk calculators and risk factors for Multiple endocrine neoplasia type 2 risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [3]
Overview
Common risk factor in the development of multiple endocrine neoplasia type 2 is family history.
Risk Factors
- Family history is the common risk factor in the development of multiple endocrine neoplasia type 2.[1]
- During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999, the risk of medullary thyroid cancer has been stratified in three categories according to the mutations of c-RET as following.
| Gene | Risk | ||
|---|---|---|---|
| Children with multiple endocrine neoplasia type 2B and/or c-RET codon 883, 918,
922 |
Highest risk of aggressive medullary thyroid cancer | ||
| Children with any c-RET codon 611, 618, 620 or 634
mutations |
High risk of medullary thyroid cancer | ||
| Children with c-RET codon 609, 768, 790, 791, 804
and 891 mutations |
Less aggressive and slowly growing medullary thyroid cancer- | Adapted from Marquard J, Eng C. Multiple Endocrine Neoplasia Type 2. 1999 Sep 27 [Updated 2015 Jun 25]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1257/[2] | |
|}
References
- ↑ [1] Wikipedia Multiple endocrine neoplasia type 2; MEN2
- ↑ Jessica Marquard & Charis Eng (1993). "Multiple Endocrine Neoplasia Type 2". PMID 020301434.