Multiple endocrine neoplasia type 2 risk factors: Difference between revisions

	Multiple endocrine neoplasia type 2 Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Multiple endocrine neoplasia type 2 from other Diseases
Epidemiology & Demographics
Risk Factors
Screening
Natural History, Complications & Prognosis
Diagnosis
Diagnostic Criteria
History & Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Multiple endocrine neoplasia type 2 risk factors On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Multiple endocrine neoplasia type 2 risk factors All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Multiple endocrine neoplasia type 2 risk factors
CDC on Multiple endocrine neoplasia type 2 risk factors
Multiple endocrine neoplasia type 2 risk factors in the news
Blogs on Multiple endocrine neoplasia type 2 risk factors
Directions to Hospitals Treating Multiple endocrine neoplasia type 2
Risk calculators and risk factors for Multiple endocrine neoplasia type 2 risk factors

Revision as of 15:18, 28 September 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [3]

Common risk factor in the development of multiple endocrine neoplasia type 2 is family history.

Family history is the common risk factor in the development of multiple endocrine neoplasia type 2..^[1]
During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999, the risk of medullary thyroid cancer has been stratified in three categories according to the mutations of c-RET as following.

**Risk Stratification**
Gene	Risk
Children with multiple endocrine neoplasia type 2B and/or c-RET codon 883, 918, 922	Highest risk of aggressive medullary thyroid cancer
Children with any c-RET codon 611, 618, 620 or 634 mutations	High risk of medullary thyroid cancer
Children with c-RET codon 609, 768, 790, 791, 804 and 891 mutations	Less aggressive and slowly growing medullary thyroid cancer

@@ Line 6: / Line 6: @@
 ==Risk Factors==
 * [[Family history]] is the common risk factor in the development of multiple endocrine neoplasia type 2..<ref>[https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia_type_2] Wikipedia Multiple endocrine neoplasia type 2; MEN2</ref>
-* During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999 [6], the risk of MTC has been stratified in three categories according to the mutations of c-RET as following.
+* During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999, the risk of medullary thyroid cancer has been stratified in three categories according to the mutations of c-''RET'' as following.
 {| style="border: 0px; font-size: 90%; margin: 3px;" align=center
 |+'''''Risk Stratification'''''
@@ Line 12: / Line 12: @@
 ! style="background: #4479BA; width: 550px;" | {{fontcolor|#FFF|Risk}}
 |-
-! style="background: #F5F5F5;" | Children with MEN2B and/or c-RET codon 883, 918,
+! style="background: #F5F5F5;" | Children with multiple endocrine neoplasia type 2B and/or c-RET codon 883, 918,
 ! style="background: #F5F5F5;" | Highest risk of aggressive [[medullary thyroid cancer]]